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As the treatment landscape for #NMIBC continues to evolve, get the insights you need to know with Medthority. Log in to hear from Joshua Meeks, Félix Guerrero-Ramos, and @ashishkamatmd.bsky.social, plus catch up with highlights from #ESMO25, #ASCO25, and more! #MedSky #OncSky

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bit.ly Glenn Hanna, MD, of Dana-Farber Cancer Institute

“I think this is tremendous. Now immunotherapy will be here and present for our head and neck [cancer] patients undergoing cancer resection,” said @danafarbernews.bsky.social’s Glenn Hanna, MD, in an Oncology Times article describing clinical trials presented at #ASCO25 and #AACR25. bit.ly/4qF4ID9

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Significant Barriers Exist in Accessing Initial Oncology Care Among Young Adults with ALL Researchers determined AYAs with ALL trying to schedule oncology appointments face logistical burdens when accessing initial oncology care.

A secret shopper study in which researchers posed as AYAs with acute #lymphoblasticLeukemia trying to schedule an #oncology appointment has found that this population faces significant logistical burdens when accessing initial oncology care.

https://bit.ly/3XBFHfA

#leusm #ASCO25

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Patient engagement in accelerating care level activation of precision medicine with patient educational materials in Nigeria: A pilot study. e13583Background: Globally, precision medicine (PM) is revolutionizing oncology treatment. PM delivers highly accurate diagnoses and targeted therapies, provides greater effectiveness for certain canc...

Local collaboration, global recognition
FT3’s partner Project Pink Blue (Nigeria) presented new findings at #ASCO25 showing how education & advocacy strengthen precision oncology access and communication.
Read the study 👉 tinyurl.com/4np3rad2
Learn more 👉 tinyurl.com/4a9z96ss
#PrecisionMedicineMonth

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Now Available: Best of Alliance at ASCO 2025 Webinar. Catch Alliance for Clinical Trials in Oncology investigators sharing key takeaways from five studies on colorectal, squamous cell, and renal cell cancers at #ASCO25. Watch at https://bit.ly/Alliance-At-ASCO American Society of Clinical Oncology

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Significant Barriers Exist in Accessing Initial Oncology Care Among Young Adults with ALL Researchers determined AYAs with ALL trying to schedule oncology appointments face logistical burdens when accessing initial oncology care.

A secret shopper study in which researchers posed as AYAs with acute #lymphoblasticLeukemia trying to schedule an #oncology appointment has found that this population faces significant logistical burdens when accessing initial oncology care. From #ASCO25.

https://bit.ly/4ib5gh0

#leusm #lymsm

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Dr. Charbel Matar highlights practical guidance shared by experts across community, private, and hospital-based oncology settings at an #ASCO25 Trainee and Early Career Lounge session.

Read more: brnw.ch/21wXiJk
#ASCOConnection

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Dr. Charbel Matar highlights practical guidance shared by experts across community, private, and hospital-based oncology settings at an #ASCO25 Trainee and Early Career Lounge session.

Read more: brnw.ch/21wXimz
#ASCOConnection

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Dr. Faith Abodunrin highlights candid reflections on navigating workload, career development, and the ever-evolving challenge of balance, shared by panelists of an #ASCO25 Trainee and Early Career Lounge session.

Read more: brnw.ch/21wXe8h
#ASCOConnection

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Dr. Shreyas Kalantri highlights practical guidance on navigating contract negotiations for early-career oncologists, shared by panelists during an #ASCO25 Trainee and Early Career Lounge session.

Read more: brnw.ch/21wWS9B
#ASCOConnection

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Sequencing IO and radiotherapy in nasopharyngeal carcinoma - VJOncology Jun Ma, MD, Sun Yat-sen University Cancer Center, Guangzhou, China, comments on the potential benefits of integrating PD-1 immunotherapy (IO)...

🎥Prof. Jun Ma of Sun Yat-sen University Cancer Center, Guangzhou, China, discusses sequencing IO and radiotherapy in nasopharyngeal carcinoma:

➡️ buff.ly/K24ba3d ⬅️

#ASCO25 #ImmunOnc #hncSM

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ASCO Connection ASCO Connection is the official member publication for members of the American Society of Clinical Oncology and the Association for Clinical Oncology.

From the Trainees and Early Career Lounge at #ASCO25 -Research 101: Identifying a Research Question and Selecting an Appropriate Study Design | @ascocancer.bsky.social connection.asco.org/do/research-...

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ASCO 2025 highlights in breast cancer: ASCENT-04, SERENA-6, and more - VJOncology Jason Mouabbi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, gives an overview of key studies in...

⭐ Jason Mouabbi, MD, of @mdanderson.bsky.social, shares an overview of key studies in breast cancer presented at #ASCO25:

🎥 buff.ly/0IeuM2Z

@ascocancer.bsky.social #BCSM #BreastCancer #CTSM #TrialUpdate #ImmunoOnc

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PROMISE: CE/BZA in postmenopausal, ER+ ductal carcinoma in situ - VJOncology Swati Kulkarni, MD, Northwestern University Feinberg School of Medicine, Chicago, IL, discusses the Phase II PROMISE study (NCT02694809), which assesses...

⭐ Swati Kulkarni, MD, discusses the PROMISE study, assessing presurgical use of conjugated CE/BZA in postmenopausal women with ER-positive DCIS:

🎥 buff.ly/FJvSAAR

@ascocancer.bsky.social #ASCO25 #BreastCancer #CTSM #TrialUpadte #SurgOnc

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Tailoring endocrine therapy: risk-based strategies and symptom management in HR+ breast cancer - VJOncology Michael Gnant, MD, FACS, Medical University of Vienna, reviews four key studies on long-term endocrine therapy in premenopausal HR+ breast...

⭐ Michael Gnant, MD, FACS, reviews long-term endocrine therapy in HR+ breast cancer: benefit for high-risk pts, ovarian suppression in ASTRRA, & elinzanetant for vasomotor symptoms:

🎥 buff.ly/hfp5orD

@ascocancer.bsky.social #ASCO25 #BreastCancer #BCSM #CTSM #TrialUpdate

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Our annual Review of Advances in Oncology: Highlights from the @ascocancer.bsky.social Annual Meeting #ASCO25 begins! We’re looking forward to a full day of updates and connections.

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Phase I/IIa trial of IVS-3001, a HLA-G-targeting CAR T-cell therapy, in solid tumors - VJOncology Samer Srour, MB ChB, MS, The University of Texas MD Anderson Cancer Center, Houston, TX, comments on an ongoing Phase...

🎥 Samer Srour, MB ChB, MS, of @mdanderson.bsky.social, discusses IVS-3001, an autologous CAR T targeting HLA-G in advanced solid tumors. Phase I/IIa trial evaluates safety, PK, and early efficacy:

Watch➡️https://buff.ly/KsUmJh8

@ascocancer.bsky.social #ASCO25 #Oncology #ImmunoOnc #CTSM #TrialUpdate

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Challenges in comparing checkpoint inhibitors in various sarcoma subtypes - VJOncology Nadia Hindi, MD, Fundación Jimenez Diaz University Hospital, Madrid, Spain, comments on the limitations of comparing immune checkpoint inhibitors in...

🎥Nadia Hindi, MD, highlights challenges in comparing ICIs vs antiangiogenic therapy in ultra-rare sarcomas. Limited data & lack of pure monotherapy cohorts make conclusions difficult—randomized trials are needed:

➡️https://buff.ly/utlNO0r⬅️

@ascocancer.bsky.social #ASCO25 #ImmunoOnc #scmSM

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7/⚡️GMMG-HD7 #ASCO25 update w/ PFS benefit in all quad recipients

↑CR 43.5% w IsaVRd v 34% w VRd
↑MRD- rate 66.2% w quad v 47.7% w triplet
👉PFS at 3yr benefit: 83% v 75% w/IsaVRd v VRd
↑MRD- regardless of maint v MRD+ (HR 0.61; P=0.002)
🔮Maintenance w Isa-len v len is on-going

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5/ PERSEUS #ASCO25: sustained MRD- in pts on quad maintenance median follow-up of 47.5m

👉 ↑ sustMRD- at ≥24m w DVRd v VRd: 55.8 v 22.6%
👉 Pts w ≥12m sustMRD-: ↑ 48m PFS, regardless of tx
👉 Only 3.1% progression at 18m w DVRd v 6.8% VRd
🔑 DVRd ➡️ 2.5x ⬆️ ≥24m sustMRD- & ½ progression risk at ≤18m tx

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Predictive biomarkers for T-DXd response in metastatic breast cancer - VJOncology Paolo Tarantino, MD, Dana-Farber Cancer Institute, Boston, MA, comments on a quantitative pre-treatment evaluation of HER2 and topoisomerase 1 (Topo1)...

🎥Can biomarkers guide T-DXd use in metastatic breast cancer?

⭐ Paolo Tarantino, MD, of @danafarber.bsky.social
reports:

🔹More HER2 mRNA/protein → longer benefit
🔹High Topo1 → worse outcomes in HER2⁻ disease

➡️https://buff.ly/G4wnu14

@ascocancer.bsky.social #ASCO25 #BreastCancer #BCSM #ImmunoOnc

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Reforming cancer research funding allocation into a criteria-based process - VJOncology Suneel Kamath, MD, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, shares his insights on the current funding disparities and the...

🎥 Dr Suneel Kamath from @clevelandclinic.bsky.social addresses cancer research funding disparities: current allocation driven by advocacy.

➡️Proposes burden-based, criteria-driven approach to ensure equity across diseases

Watch🔗https://buff.ly/d2uKbEB

@ascocancer.bsky.social #ASCO25 #Oncology

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Addressing disparities in chemotherapy acceptance: barriers and potential solutions - VJOncology Inimfon Jackson, MD, PhD, MPH, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses disparities in chemotherapy acceptance...

🎥Dr Inimfon Jackson from @mdanderson.bsky.social
discusses disparities in chemo acceptance:

➡️Greatest in uninsured/publicly insured & Black patients. Advocates trust-building, early risk ID & informed decision support.

🔗 buff.ly/nttGH5r

@ascocancer.bsky.social #ASCO25 #Oncology

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Addressing the escalating impact of alcohol on cancer outcomes - VJOncology Chinmay Jani, MBBS, Sylvester Comprehensive Cancer Center, Doral, FL, comments on the potential relationship between alcohol consumption and cancer mortality,...

🎥 @janichinmay.bsky.social explores alcohol’s role in cancer mortality:

➡️Calls for age/geography–stratified analyses & focus on mechanisms incl. microbiome & ICI interaction.

Learn more here🔗 buff.ly/zcvqHJd

@ascocancer.bsky.social #ASCO25 #Oncology #ImmunoOnc

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Evaluating erythrocyte-antibody conjugates in solid tumors - VJOncology Xiaoqian Nie, PhD, Westlake University, Hangzhou, China, shares results of a Phase I trial (NCT06026605) investigating erythrocyte-antibody conjugates in cancers...

🎥 Xiaoqian Nie, PhD, reports Phase I data:

➡️Erythrocyte–antibody conjugates show stronger antitumor activity & better safety vs PD-1 antibodies in checkpoint-refractory cancers. Promising novel IO strategy

🔗 buff.ly/cD7UDXr

@ascocancer.bsky.social #ASCO25 #Oncology #ImmunoOnc #CTSM #TrialUpdate

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Tissue-free versus tissue-reliant ctDNA testing in solid tumors - VJOncology John Paul Shen, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, compares recent methylation-based tissue free testing...

🎥 Dr John Paul Shen (@mdanderson.bsky.social) compares methylation-based tissue-free ctDNA assays vs tissue-reliant approaches.

➡️ Sensitivity varies by tumor site & mutation profile—trials needed to define accuracy in MRD detection.

🔗 buff.ly/cGkX0l2

@ascocancer.bsky.social #ASCO25 #Oncology

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Precision medicine in pediatric cancer treatment - VJOncology Francois Doz, MD, Institut Curie, Paris, France, emphasizes the potential of precision medicine in pediatric cancers, particularly in cases like...

🎥 Prof. Francois Doz (@institutcurie.bsky.social) emphasizes precision medicine in pediatric cancer

➡️Trials like iMATRIX Alectinib show promise, but rapid molecular profiling at diagnosis remains a barrier to real-world adoption.

🔗 buff.ly/qJueBU3

@ascocancer.bsky.social #ASCO25 #Oncology #CTSM

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The emergence of targeted therapies and ICIs for brain metastasis - VJOncology Manmeet Ahluwalia, MD, MBA, FASCO, Baptist Health South Florida, Miami, FL, provides an overview of the evolving treatment landscape for...

🎥 Manmeet Ahluwalia, MD, notes the shift in brain metastasis care: from surgery & WBRT ➡️ targeted therapies & ICIs. Next: combinations with ADCs + ICIs while balancing radiation toxicity.

🔗 buff.ly/Q988SOT

@ascocancer.bsky.social #ASCO25 #ImmunoOnc #Oncology #SurgOnc

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Disparities in cancer screening among LGBTQ+ populations in the US - VJOncology Manas Pustake, MD, Texas Tech University Health Science Center, El Paso, TX, comments on the significant disparities in cancer screening...

🎥 Manas Pustake, MD, highlights disparities in cancer screening access for LGBTQ+ populations vs. non-LGBTQ+ groups in the US, emphasizing the need for targeted interventions:

➡️ buff.ly/5ti0xQr ⬅️

@ascocancer.bsky.social #ASCO25 #Oncology

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PSMA PET predictors of response to 225Ac-J591 in mCRPC - VJOncology Valentina Marulanda Corzo, MD, Weill Cornell Medicine, New York, NY, discusses findings from early-phase trials (NCT03276572, NCT04506567, NCT04886986, NCT04946370) assessing...

🎥 Valentina Marulanda Corzo, MD, discusses findings from early-phase trials assessing baseline and follow-up PSMA PET parameters in patients with mCRPC treated with 225Ac-J591:

➡️ buff.ly/777PV9f ⬅️

@ascocancer.bsky.social #ASCO25 #PCSM #UroOnc #UrsoSoMe #TrialUpdate #CTSM

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