Whole Brain Emulation Achieved: Scientists Run a Fruit Fly Brain in Simulation Scientists have copied an entire biological brain neuron by neuron and synapse by synapse and made it control a simulated body that can walk, groom, and behave. This achievement is known as whole brain emulation the process of recreating a biological brain inside a computer simulation so its neural circuits can produce real behavior. History’s First Whole-Brain Upload Just Took Its First Steps In 7th March 2025…

Scientists achieved whole brain emulation by running a fruit fly brain with 127k neurons and 50M synapses inside a simulated body. The connectome now drives real-time behavior in simulation, demonstrated by Eon Systems.

#WholeBrainEmulation #Neuroscience #Connectome #BrainSimulation #eon #AI

Scientists complete the first full wiring diagram of a fruit fly brain from boingboing rss feed

Scientists complete the first full wiring diagram of a fruit fly brain
boingboing.net/2026/02/25/scientists-co...
#brain_mapping #connectome #fruit_fly #neuroscience #Science #boingboing

Exercise rewires the brain — boosting the body’s endurance The more mice exercise, the more connections form between some neurons in their brains, study finds.

Exercise rewires the brain — boosting the body’s endurance

www.nature.com/articles/d41...

#Connectome #Neuro

Once Thought To Support Neurons, Astrocytes Turn Out To Be in Charge | Quanta Magazine New experiments reveal how astrocytes tune neuronal activity to modulate our mental and emotional states. The results suggest that neuron-only brain models, such as connectomes, leave out a crucial la...

🧪 WOW: 🧠= 🤯

[clinical neuroscience just got more complex 😹😹😹]

Once Thought To Support Neurons, Astrocytes Turn Out To Be in Charge

www.quantamagazine.org/once-thought...

#Connectome #Synaptome #Astrocytome #Consciousness #Neuroscience

If you could upload your consciousness to a server and live forever, would you press the button?

Or is there something about our "meat suits" that a string of code can never replicate? I’m genuinely torn on this one. What do you think? 🧠💻 #MetaversePlanet #Connectome #TechEthics

Ki -kivel van? Molekuláris Facebook az agyban.
koki.hun-ren.hu/ismeretterje...
#agykutatás #agyműködés #idegtudományok #neurobiológia #tudományosblog #biológia #természettudomány #szürkeállomány #agytechnikak #vizualizáció #bigdata #connectome #agyipalyak

Mapping the Metabolic Connectome Reveals the Brain's Hidden Chemical Organization - Daily Neuron Scientists created the first human metabolic connectome using advanced MRI, revealing a new map of the brain's biochemical organization and its link to genetics.

Scientists created the first human metabolic connectome using advanced MRI, revealing a new map of the brain’s biochemical organization and its link to genetics. #neuroscience #connectome #biochemistry

dailyneuron.com/metabolic-co...

Belated #Connectome day 2 post as there was too much fantastic science and great fun to post at the time! Highlights on Tuesday include an incredible keynote by Erin Schuman, Rory Cellan-Jones discussing his experiences and giving us scientists a good grilling, and a wonderful conference dinner!

Biological sex classification with structural MRI data shows increased misclassification in transgender women - Neuropsychopharmacology Neuropsychopharmacology - Biological sex classification with structural MRI data shows increased misclassification in transgender women

Nature: Open access 🧪
Published: 09 April 2020

Biological sex classification with structural MRI data shows increased misclassification in transgender women

www.nature.com/articles/s41...

#LGBT+ #Neuro #CdnPoli #AbLeg #Connectome

A mouse brain atlas based on dendritic microenvironments - Nature Neuroscience The authors developed a mouse brain atlas using local dendritic morphological patterns from 101,136 neurons. This representation not only improves anatomical precision but also uncovers associations b...

A mouse brain atlas based on dendritic microenvironments 🧪

www.nature.com/articles/s41...

#Connectome #Neuroscience

I am incredibly honoured to share that I have been awarded the @ukdri.ac.uk PhD Prize at #Connectome 2025! @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

@ukdri.ac.uk #Connectome day 1 highlight: a fantastic keynote by Prof Malcolm Macleod on improving the quality and usefulness of our science, including this example of neural correlates in a dead fish

ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development Hass et al. show that ARHGAP11A safeguards ventricular zone integrity during human cortical development. By controlling cytoskeletal dynamics through the RHOA-ROCK pathway, ARHGAP11A prevents prematur...

ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development 🧪

www.cell.com/cell-reports...

#Connectome #Neuroscience #Genetics #STEM

Come Join US Fully funded PhD position available:

*Also we do have a PhD position open to continue this investigation with the aid of #connectome in collaboration with Nils Reinhard @nils-reinhard.bsky.social
See details at https://www.kofanchenlab.net/come-join-us

Our findings in females build on the incredible work from @ceschretter.bsky.social on aIPg cells.

Also big s/o to the team @hhmijanelia.bsky.social and the Lab of @jefferis.bsky.social for generating the male brain #connectome dataset. Such an amazing resource and it was a pleasure to dig into.

Original post on mastodon.social

The #connectome may be important, but it does not seem to help understand neuronal activity patterns:

"Comprehensive neuronal identification enabled us to examine the relationship between whole-brain activity and the connectome but we found no strong correlations between them." […]

Original post on mastodon.social

How much can a #connectome tell us about the activity of neurons? It seems not all that much:

"neuronal perturbation often prompted responses from cells that had no anatomical connections to the target cell" […]

Join us TODAY at 3 pm US Pacific time for "Connectomic traces of Hebbian plasticity in the entorhinal-hippocampal system" at carboncopies.org/aspirational... #memorydecoding #aspirationalneuroscience #hippocampal #plasticity #connectome

Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth - Molecular Psychiatry Molecular Psychiatry - Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth

New paper from @annierhcheng.bsky.social

using data from IMAGEN and ABCD she identifies distinct signatures of impulsivity and negative affect in youth that uniquely overlap with a neuromarker of risky alcohol use

#development #equifinality #abcd #connectome

www.nature.com/articles/s41...

a drawing of mushrooms growing out of a person 's head ALT: a drawing of mushrooms growing out of a person 's head

I wrote a Research Highlight for @npp-journal.bsky.social - based on the recent work of Jakub Vohryzek - describing Connectome Harmonics and how they can help us to understand the psychedelic experience. #Psychedelics #Consciousness #Connectome Read it here www.nature.com/articles/s41...

Morphological rendering of cells in the ctenophore apical organ showing the four quadrants and the balancer cilia supporting a statolyth.

We have received the reviews for our "Neural #Connectome of the Ctenophore Statocyst" paper from @eLife

"This fundamental work significantly advances our understanding of gravity sensing and orientation behavior in the ctenophore, an animal of major […]

[Original post on biologists.social]

Original post on biologists.social

At long last, the version of record of our paper on the #Platynereis #connectome

"Whole-body connectome of a segmented annelid larva" is out.

Explore the rich online presentation with all the videos, figures and source data here:

https://doi.org/10.7554/eLife.97964

@eLife
@biology […]

ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.

Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8

Neuronal wiring diagram of an adult brain - Nature FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosyst...

Neuronal wiring diagram of an adult brain

www.nature.com/articles/s41...

#Connectome 🧪

Multilayer Network Neuroscience: Decoding the Brain’s Complex Systems

#NetworkNeuroscience #BrainConnectivity #Connectome #Neuroscience #BrainMapping #BrainResearch #Neurotechnology #PersonalizedMedicine #BrainHealth #CognitiveScience #Neuroimaging #BrainScience

youtube.com/shorts/LdGsi...

Volume rendering of the ctenophore aboral organ reconstructed by volume EM, showing the gravisensory balancers and the four quadrants.

In our new preprint we describe the synaptic #connectome of the nerve net in the ctenophore gravisensory organ. www.biorxiv.org/content/10.1101/2025.06.... #biology #neuroscience #ctenophore #vEM

Good morning #ohbm2025! We still have a host of great posters to present over the last two days of the conference so keep your eyes peeled 👀

1573 - #multi-echo #fMRI
1666 - #heterogenous modes
1696 - new #psychosis dataset
1708 - #eigenmodes in #mice
1773 - linking #geometry & #connectome

Details👇

Two sets of connecting fly neurons with fine, wispy arbors.

Cleaning up disk space, I found this image I made for someone not long after the release of the #HHMIJanelia #Drosophila hemibrain #connectome in 2020. It shows EPG neurons in pink providing inputs to PFL1 neurons in transparent grey. I'm not sure if the image was ever used.

Norepinephrine changes behavioral state through astroglial purinergic signaling Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...

Neuroscience wasn’t hard enough, so, let’s just add another cognitive parameterization. 🧪 😂

Norepinephrine changes behavioral state through astroglial purinergic signaling

www.science.org/doi/10.1126/...

#Neuroscience #Connectome #Synaptome #Transcriptome #Topology #Psychology #STEM #Science

Comparative connectomics of Drosophila descending and ascending neurons - Nature Three electron microscopy datasets are combined to provide a complete connectomic description of the neural circuitry that makes up the neck connective in Drosophila, including the descendin...

Fruit fly brain reveals sex-specific differences:🧪

Comparative connectomics of Drosophila descending and ascending neurons

www.nature.com/articles/s41...

#Sex #Neuroscience #Connectome