Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky
@bcmhouston.bsky.social @washumedicine.bsky.social #AlzheimersDisease #GABAergic

link.springer.com/article/10.1...

#ARX, #GSX2 and members of the #DLX family were identified as key #TFs regulating #GABAergic related networks in #GB.

#GABAergic neuron-to-glioma synapses were recently found in #DMG/#DIPG, but not #GB @michellemonje.bsky.social @tarabarron.bsky.social

Yet our ML-based analysis flagged #GABA signalling as key in #GB. Notably, we showed that #GABAergic neurons promote #GB cell proliferation in co-culture assays.

Anaesthetists target neural circuits regulating #sleep in general anaesthesia. Eliminating parafacial zone #GABAergic neurones altered anaesthetic sensitivity without causing insomnia #OpenAccess #Neurobiology

Astrocytes, via RTP801, contribute to cognitive decline by disrupting GABAergic‐regulated connectivity and driving neuroinflammation in an Alzheimer's disease mouse model INTRODUCTION Alzheimer's disease (AD) pathogenesis involves astrocytic responses to extracellular amyloid beta deposits and phospho-tau neurofibrillary tangles, which drive inflammatory activation. ...

@ub.edu @ubneuro.bsky.social @idibaps.bsky.social @ciberned @ageinves.bsky.social
#AlzheimersDisease #Neuroinflammation #Astrocytes #Neuroscience #GABAergic #CognitiveDecline #Neurodegeneration #Research #RTP801 #ScientificPublication

Crossover study to investigate the effect of increased #GABAergic inhibition via GABAB-receptor agonist baclofen on motor learning and Multi-Echo #MRI (#MRSI) metrics. #DWCRT Concentric Ring Trajectory
www.biorxiv.org/content/10.1...