Clade C #MERS-CoV #camel #strains vary in #protease utilization during viral entry

Clade C #MERS-CoV #camel #strains vary in #protease utilization during viral entry, etidiohnew.blogspot.com/2026/04/clad...

A Native Nepenthesin Reactor for Improved Proteolytic Digestion of Intrinsically Disordered Proteins in Proteomics Workflows A workflow is presented for the extraction and purification of native nepenthesin (NEP-NAT) from Nepenthes species, followed by the enzyme's immobilization on POROS-AL chromatographic material. The N...

Latest publication from SNP2Prot colleagues C. Wall and A. Sinz reveals that the Nepenthesin protease, isolated from 𝘕𝘦𝘱𝘦𝘯𝘵𝘩𝘦𝘴 sp., carries superior proteolytic activity towards IDPs.

Kudos to the team 🎉

doi.org/10.1002/cbic...

#MassSpec #Protease #IDPs
#Proteomics

@sinzandrea.bsky.social

Computational Evaluation of Philippine Vitex negundo #Phytochemicals as Potential Inhibitors of #Rhinovirus 3C #Protease: #Molecular Docking, #Pharmacokinetic Analysis, and ADMET Studies

by Francis Ceniza et al.

Eng. Proc. 2026, 124(1), 90; www.mdpi.com/2673-4591/12...

Antibiotic resistance is rising: A membrane protease could be E. coli's weak spot A University of Alberta research team has identified a new drug target to treat harmful E. coli bacteria—which cause nearly 250,000 deaths a year from urinary tract infections (UTI) and are becoming…

Membrane #protease could be E. coli's weak spot ...

| #Ecoli | #bacteria | #Antibioticresistance | #infection | #pathogen | By @ualberta.bsky.social via @sciencex.bsky.social

@cnaumann123.bsky.social invited @degradomics.bsky.social from @uni-freiburg.de as #SNP2Prot seminar speaker. It is always a pleasure to discuss with a fellow #protease researcher!

Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action

Scientists identify four dihydropyrimidone derivatives as potent #nonpeptidic activators of HslV #protease, with sub‑micromolar efficacy, stable binding, and drug‑like properties, highlighting HslVU hyperactivation as a #antibacterial strategy.
Open Chemistry: doi.org/10.1515/chem...

⏪ G&D RECAP ⏪

🗓️ April 2025
OUTLOOK: Where and why have so many metabolic enzymes gone from developing spores of Bacillus subtilis?
By Peter Setlow
➡️ https://genesdev.cshlp.org/content/39/7-8/426.full

#bacteria #sporulation #protease #metabolism #dormancy

⏪ G&D RECAP ⏪

🗓️ April 2025
RESEARCH PAPER: MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
By Massoni et al., Rivka Isaacson, and Amy Camp
➡️ https://genesdev.cshlp.org/content/39/7-8/510.full

#bacteria #sporulation #protease #metabolism #dormancy

SA Script History! Highest Chase Stuns India | Kohli, Gaikwad Tons in Vain! YouTube video by Sitarah Anjum Official

SA Pull Off Epic Record Chase. Kohli, Gaikwad Shine but… India Still Lose!
Watch my #CricketAnalysis on YouTube.

#INDvsSA #ViratKohli #TembaBavuma #Protease

www.youtube.com/live/T9GJu4r...

Omicron has also experimented with changes in viral entry mechanisms, such as #protease usage, which may signal shifts in host cell tropism & the identification of new sites of cell vulnerability .

#Medsky🧪 #immunosky #oncosky #microsky #drugdevelopment @science.org
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.

#Microbiome #PAR2 #Protease #Inflammation #PainResearch @pazduran.bsky.social @karapedsgastrodoc.bsky.social @karapedsgastrodoc.bsky.social

Jie Huang ( #PlantChemetics lab) and I wrote a dispatch on Zhang et al.'s work (www.nature.com/articles/s41...) describing a #protease effector that cleaves the extracellular domain of a plant receptor-like kinase, and it's none other than BAK1!

Enjoy!
authors.elsevier.com/a/1ldGk3QW8S...

Proteases are involved in processes like immunity, cancer progression, and viral replication. Small molecule protease inhibitors help control these enzymes with high specificity, useful in both research and therapeutic applications. 🧪
fluorochem.co.uk/product-cate...
#SMI #protease #ChemSky #cancer

Cathepsin L plays a crucial role in the diversity and functionality of T cells An international team led by Ludger Klein has provided important insights into the maturation of T cells in the thymus, which is a central process in the development of a functioning immune system.

📣 New in @natimmunol.nature.com:
#Cathepsin L plays a crucial role in the diversity and functionality of #CD4 #Tcells

➡️ www.med.lmu.de/bmc/en/news/...

#cortical #epithelial #cells #receptor #thymus #immune #immunology #MHC #major #histocompatibility #complex #cysteine #protease

📷 J.Greune

#Protease #SouthAfrica

Identification of naturally occurring #drug-resistant #mutations of #SARS-CoV-2 papain-like #protease

Identification of naturally occurring #drug-resistant #mutations of #SARS-CoV-2 papain-like #protease, etidiohnew.blogspot.com/2025/05/iden...

#chemsky #protease #drugdiscovery #chembio

Howard G. Smith MD, AM on Instagram: "Protease Blood Test Signals Pancreatic Cancer Pancreatic ductal carcinoma, a particularly deadly form of this dread cancer, emits a tell-tale enzymatic change th... 0 likes, 0 comments - drhowardsmithreports on February 21, 2025: "Protease Blood Test Signals Pancreatic Cancer Pancreatic ductal carcinoma, a particularly deadly form of this dread cancer, emits a t...

Cancer biologists at the Oregon Health & Science University have developed a blood test, the PAC-MANN, that detects a deadly form of pancreatic cancer with an 85% accuracy for early-stage cases. #pancreatic #cancer #protease #pacmann

www.instagram.com/drhowardsmit...

Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2 Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation and pain. Upregulated intestinal proteolysis and PAR2-signaling are implicated in inflammatory ...

Thrilled to share our new preprint: The gut #microbe B. fragilis secretes a unique #protease (Bfp1) that activates the human PAR2 receptor, driving intestinal pain & inflammation—key features of #IBD. Huge thanks to the amazing teams of @mbogyo.bsky.social, Nigel Bunnett and Alan Lomax! t.ly/mqyPk

Our first paper of #2025! We identified viral-selective, non-covalent inhibitors of #coronavirus #3CL main #protease using a DNA-encoded library, and optimized them using x-ray crystallography. www.nature.com/articles/s41...

Cellulase, xylanase, lipase, and protease activities of selected wild  mushrooms from Slovenia

Cellulase, xylanase, lipase, and protease activities of selected wild mushrooms from Slovenia

#scicomm
#mushroom
#enzyme
#cellulase
#xylanase
#lipase
#protease

journals.uni-lj.si/abs/article/...

🪩Today’s #Editorschoice article will put a #festiveFEBSJ PPEP in your step 💃:

Hensbergen & team explore the structure–function relationship and #protease specificity of pro-pro endopeptidases (PPEPs).

🔎Discover more here: https://buff.ly/3OXNFLD

A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV Ibuzatrelvir (1) was recently disclosed and patented by Pfizer for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has received fast-track status from the USA Food an...

Chen et al (JACS Au 2024) A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main #Protease (#Mpro) of SARS-CoV-2 and MERS-CoV. JACS Au #coronarvirus #antiviral #DrugDesign #StructBiol #MedChem #cheminformatics #OpenAccess #chemsky 🧪
doi.org/10.1021/jacs...