Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action

Scientists identify four dihydropyrimidone derivatives as potent #nonpeptidic activators of HslV #protease, with sub‑micromolar efficacy, stable binding, and drug‑like properties, highlighting HslVU hyperactivation as a #antibacterial strategy.
Open Chemistry: doi.org/10.1515/chem...