By recording #cortical #angiograms during i.v. injection of FITC-dextran 🟢 in #adult and #old #NG2DsRed mice, we time-colored the #arterioles 🔴 and #venules 🔵. We found that #OldMice have less #collaterals and more #tortuous #PenetratingArterioles.

Figure showing how we measured microvascular diameters by transverse line scanning to assess the diameter pulsatility and the pulsatility of the centers of the vessels.

#OldMice also showed decreased pulsations of microvessel diameters measured by transverse line scans, likely due to #VascularStiffening.