Check out this great review by Osama Harraz et al., Brain Capillary Ion Channels: Physiology and Channelopathies
➡️ https://ow.ly/Jenc50YCOSA
#BrainCapillaries #IonChannels

Behringer et al. from @tuda.bsky.social show how coarse-grained computational methods uncover long-range mechanical connectivities in HCN #IonChannels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article/...

📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...

#IonChannels #CallForPapers

Ion Channels in Organ Microcirculatory Control: Emerging Ideas and Pathological Relevance Ion Channels in Organ Microcirculatory Control: Emerging Ideas and Pathological Relevance - Find out more about this two day meeting.

This summer, explore the intricate molecular mechanisms of vascular ion channels to their influence on complex physiological functions:
📆 27 – 28 August
📍 University of Oxford, UK

From discussing discoveries to the development of therapies, join us at our #IonChannels meeting ⬇️

Deep learning as a generator of sodium channel state hypotheses. Lisa Schmidt and Wojciech Kopec @mpi-nat.bsky.social discuss recent work by Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social (rupress.org/jgp/article/...) in Commentary: rupress.org/jgp/article/...
#IonChannels

Sequential membrane remodeling by #cholesterol distinctly modulates HCN channels in naïve & neuropathic DRG neurons. New study by Lucas J. Handlin, Gucan Dai (@gucandai.bsky.social) et al (Saint Louis University School of Medicine): rupress.org/jgp/article/...

#lipids #Biophysics #Pain #IonChannels

Channels and Transporters in Immunity. Explore how ion channels and transporters shape immune responses, inflammation, and disease at this cross-disciplinary immunology conference.

📢 If you are working at the intersection of #ionchannels and #transporters in #immunity, we invite you to join us and share your research. We look forward to seeing you at #CTImmSRC #FASEB Conference in #NiagaraFalls
👉 events.faseb.org/event/7cca57...

Redirecting

🧫Just published online in JPS❣️ (📖 Open Access!! 14 March 2026)
“Dynamic Regulation of TASK-1 Channels Under Cellular Stress”
— Yang Yu et al.
🔗 doi.org/10.1016/j.jp...
#IonChannels #CellStress #TASK1 #Electrophysiology #NowOnline #JPhysiolSci

#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...

#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...

Opening of rod #photoreceptor CNG channels by photodynamically generated singlet oxygen. New study from Gaogao He, Lei Zhou and colleagues (Shenzhen Bay Laboratory): rupress.org/jgp/article/...

#Biophysics #MolecularPhysiology #IonChannels

Deep learning as a generator of sodium channel state hypotheses Schmidt and Kopec discuss how Lopez-Mateos et al. use AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different confor

Commentary @jgp.org: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/...

#IonChannels

Commentary: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/...

#IonChannels

Welsh firm Antiverse raises funds for AI antibody platform Cardiff's Antiverse has raised $9.3m to develop its AI-based design platform for antibodies against hard-to-reach targets like GPCRs and ion channels.

#Antiverse #AI #AIantibodyplatform #biotech #drugdiscoveryprogrammes #antibodybasedtherapeutics #antibodies #drugtargets #Gproteincoupledreceptors #GPCR #ionchannels #NxeraPharma #GPCRs #cellularcommunication #transmembraneprotein #Tcellreceptor #TCR #antiPD1antibodies #drugdiscovery
zurl.co/cAKcg

Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics #MolecularPhysiology

In @jgp.org, Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics

What is Dravet syndrome - Dravet Syndrome Foundation What is Dravet Syndrome? Dravet syndrome is a rare form of intractable epilepsy that begins in infancy and significantly impacts individuals throughout their lifetime.

More details on Dravet Syndrome 🧪🧠💊:

What is Dravet Syndrome?

#ionchannels
dravetfoundation.org/what-is-drav...

📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...

#IonChannels #CallForPapers #WSCC26

🗓️📌 Get your virtual seat for our first webinar of 2026 events.teams.microsoft.com/event/cb12ab... ​
​
Agenda | 1 Hour​
​
🗓️ Wednesday 18 March | 1:30 – 2:30 PM CET ​
📍 Online ​
​
#Neuroscience #VirtualLabs #DigitalBrainModels #NeuronModeling #IonChannels

One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels The modulator pocket is a cryptic site discovered in the TREK1 (K2P2.1) K2P channel. This pocket, located close to the selectivity filter, accommodates agonists that enhance the channel’s activity....

🙂 Happy to share our contribution to improving the understanding of #ionchannels! In this review, the authors attempt to elucidate how the modulator pocket contributes to #K2P channel activation. #TREK1 #MD #C-type inactivation #ML335 #review @wojciechkopec.bsky.social

👉 doi.org/10.1080/1933...

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel. New study from Yuki K. Maeda, Katsumasa Irie and colleagues (Wakayama Medical University): rupress.org/jgp/article/...

#Biophysics #IonChannels

Did you know that @ninds is developing an RM1 funding mechanism to support team science focused on a single goal?

Just learned about it in the "Inside NIH" session organized by the Advocacy Committee at #BPS2026.

Coming soon at #nih.
#Biophysics #neuroscience #ionchannels

Scientists Discover Why We Know When to Stop Scratching an Itch BETHESDA, MD – When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels “enough,” is not accidental. Scientists have now identified a key…

#BPS2026 Newsroom Spotlight - Scientists Discover Why We Know When to Stop Scratching an Itch #ionchannels #mechanosensation #calciumimaging #neurons #eczema #psoriasis #kidneydisease

P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics Cowley et al. show that CNS-penetrant, selective P2X7 receptor antagonists reduce the release of pro-inflammatory cytokines from human microglia and brain

P2X7 antagonists showing promise for suppression of neuroinflammatory responses. Our paper out in Brain now. #ionchannels

academic.oup.com/brain/advanc...

Past, present, and future Presidents of the @biophysicalsoc.bsky.social! Celebrating science and friendship!
#BPS2026 #science #ionchannels

With my bluesky buddy @markusdeserno.bsky.social enjoying the BPS President's Reception! Hobnobbing with the smart and famous!
#BPS2026 #science #ionchannels

The Biophysical Society > Meetings & Events > Annual Meeting > 2026 Annual Meeting > Program > Satellite Meetings > Drug Discovery for Ion Channels XXVI Friday, February 20, 8:00 AM - 5:15 PM Esplanade, Room 153, Moscone Center

View the Drug Discovery for #IonChannels XXVI satellite meeting program, taking place today at #bps2026

Voltage-gated sodium channels (Navs) exhibit high Li⁺ selectivity similar to Na⁺. In @jgp.org, Maeda, Irie et al. present the first prokaryotic Nav mutant that conducts Li⁺ with approximately twice the efficiency of Na⁺. rupress.org/jgp/article/...

#Biophysics #IonChannels

Voltage-gated sodium channels (Navs) exhibit high Li⁺ selectivity similar to Na⁺. Maeda, Irie et al. present the first prokaryotic Nav mutant that conducts Li⁺ with approximately twice the efficiency of Na⁺. rupress.org/jgp/article/...

#Biophysics #IonChannels

Introducing a new addition to our PSAM/PSEM range! 🙌

PSEM89S is a new brain penetrant PSAM agonist which binds to a pharmacologically selective actuator module of genetically engineered chimeric ion channels. 🔬

Take a look at this great new product: ow.ly/VpM550Yhw95

#chemogenetics #ionchannels