📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...

#IonChannels #CallForPapers

Ion Channels in Organ Microcirculatory Control: Emerging Ideas and Pathological Relevance Ion Channels in Organ Microcirculatory Control: Emerging Ideas and Pathological Relevance - Find out more about this two day meeting.

This summer, explore the intricate molecular mechanisms of vascular ion channels to their influence on complex physiological functions:
📆 27 – 28 August
📍 University of Oxford, UK

From discussing discoveries to the development of therapies, join us at our #IonChannels meeting ⬇️

Deep learning as a generator of sodium channel state hypotheses. Lisa Schmidt and Wojciech Kopec @mpi-nat.bsky.social discuss recent work by Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social (rupress.org/jgp/article/...) in Commentary: rupress.org/jgp/article/...
#IonChannels

Sequential membrane remodeling by #cholesterol distinctly modulates HCN channels in naïve & neuropathic DRG neurons. New study by Lucas J. Handlin, Gucan Dai (@gucandai.bsky.social) et al (Saint Louis University School of Medicine): rupress.org/jgp/article/...

#lipids #Biophysics #Pain #IonChannels

Channels and Transporters in Immunity. Explore how ion channels and transporters shape immune responses, inflammation, and disease at this cross-disciplinary immunology conference.

📢 If you are working at the intersection of #ionchannels and #transporters in #immunity, we invite you to join us and share your research. We look forward to seeing you at #CTImmSRC #FASEB Conference in #NiagaraFalls
👉 events.faseb.org/event/7cca57...

Redirecting

🧫Just published online in JPS❣️ (📖 Open Access!! 14 March 2026)
“Dynamic Regulation of TASK-1 Channels Under Cellular Stress”
— Yang Yu et al.
🔗 doi.org/10.1016/j.jp...
#IonChannels #CellStress #TASK1 #Electrophysiology #NowOnline #JPhysiolSci

#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...

#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...

Opening of rod #photoreceptor CNG channels by photodynamically generated singlet oxygen. New study from Gaogao He, Lei Zhou and colleagues (Shenzhen Bay Laboratory): rupress.org/jgp/article/...

#Biophysics #MolecularPhysiology #IonChannels

Deep learning as a generator of sodium channel state hypotheses Schmidt and Kopec discuss how Lopez-Mateos et al. use AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different confor

Commentary @jgp.org: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/...

#IonChannels

Commentary: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/...

#IonChannels

Welsh firm Antiverse raises funds for AI antibody platform Cardiff's Antiverse has raised $9.3m to develop its AI-based design platform for antibodies against hard-to-reach targets like GPCRs and ion channels.

#Antiverse #AI #AIantibodyplatform #biotech #drugdiscoveryprogrammes #antibodybasedtherapeutics #antibodies #drugtargets #Gproteincoupledreceptors #GPCR #ionchannels #NxeraPharma #GPCRs #cellularcommunication #transmembraneprotein #Tcellreceptor #TCR #antiPD1antibodies #drugdiscovery
zurl.co/cAKcg

Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics #MolecularPhysiology

In @jgp.org, Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...

#Biophysics

What is Dravet syndrome - Dravet Syndrome Foundation What is Dravet Syndrome? Dravet syndrome is a rare form of intractable epilepsy that begins in infancy and significantly impacts individuals throughout their lifetime.

More details on Dravet Syndrome 🧪🧠💊:

What is Dravet Syndrome?

#ionchannels
dravetfoundation.org/what-is-drav...

📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...

#IonChannels #CallForPapers #WSCC26

🗓️📌 Get your virtual seat for our first webinar of 2026 events.teams.microsoft.com/event/cb12ab... ​
​
Agenda | 1 Hour​
​
🗓️ Wednesday 18 March | 1:30 – 2:30 PM CET ​
📍 Online ​
​
#Neuroscience #VirtualLabs #DigitalBrainModels #NeuronModeling #IonChannels

One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels The modulator pocket is a cryptic site discovered in the TREK1 (K2P2.1) K2P channel. This pocket, located close to the selectivity filter, accommodates agonists that enhance the channel’s activity....

🙂 Happy to share our contribution to improving the understanding of #ionchannels! In this review, the authors attempt to elucidate how the modulator pocket contributes to #K2P channel activation. #TREK1 #MD #C-type inactivation #ML335 #review @wojciechkopec.bsky.social

👉 doi.org/10.1080/1933...

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel. New study from Yuki K. Maeda, Katsumasa Irie and colleagues (Wakayama Medical University): rupress.org/jgp/article/...

#Biophysics #IonChannels

Did you know that @ninds is developing an RM1 funding mechanism to support team science focused on a single goal?

Just learned about it in the "Inside NIH" session organized by the Advocacy Committee at #BPS2026.

Coming soon at #nih.
#Biophysics #neuroscience #ionchannels

Scientists Discover Why We Know When to Stop Scratching an Itch BETHESDA, MD – When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels “enough,” is not accidental. Scientists have now identified a key…

#BPS2026 Newsroom Spotlight - Scientists Discover Why We Know When to Stop Scratching an Itch #ionchannels #mechanosensation #calciumimaging #neurons #eczema #psoriasis #kidneydisease

P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics Cowley et al. show that CNS-penetrant, selective P2X7 receptor antagonists reduce the release of pro-inflammatory cytokines from human microglia and brain

P2X7 antagonists showing promise for suppression of neuroinflammatory responses. Our paper out in Brain now. #ionchannels

academic.oup.com/brain/advanc...

Past, present, and future Presidents of the @biophysicalsoc.bsky.social! Celebrating science and friendship!
#BPS2026 #science #ionchannels

With my bluesky buddy @markusdeserno.bsky.social enjoying the BPS President's Reception! Hobnobbing with the smart and famous!
#BPS2026 #science #ionchannels

The Biophysical Society > Meetings & Events > Annual Meeting > 2026 Annual Meeting > Program > Satellite Meetings > Drug Discovery for Ion Channels XXVI Friday, February 20, 8:00 AM - 5:15 PM Esplanade, Room 153, Moscone Center

View the Drug Discovery for #IonChannels XXVI satellite meeting program, taking place today at #bps2026

Voltage-gated sodium channels (Navs) exhibit high Li⁺ selectivity similar to Na⁺. In @jgp.org, Maeda, Irie et al. present the first prokaryotic Nav mutant that conducts Li⁺ with approximately twice the efficiency of Na⁺. rupress.org/jgp/article/...

#Biophysics #IonChannels

Voltage-gated sodium channels (Navs) exhibit high Li⁺ selectivity similar to Na⁺. Maeda, Irie et al. present the first prokaryotic Nav mutant that conducts Li⁺ with approximately twice the efficiency of Na⁺. rupress.org/jgp/article/...

#Biophysics #IonChannels

Introducing a new addition to our PSAM/PSEM range! 🙌

PSEM89S is a new brain penetrant PSAM agonist which binds to a pharmacologically selective actuator module of genetically engineered chimeric ion channels. 🔬

Take a look at this great new product: ow.ly/VpM550Yhw95

#chemogenetics #ionchannels

Related: Harold Zakon and colleagues showed that brain evolution is associated with explosive rounds of duplications of #receptors and #ionchannels.

www.pnas.org/doi/10.1073/...

#neuroskyence

Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review Bioactive compounds derived from secondary metabolism in animals have refined selectivity and potency for certain biological targets. The superfamily Dendrobatoidea is adapted to the dietary seques...

Open access review on toxic compounds derived from the frog superfamily Dendrobatoidea 🧪🐸:

Bioactive alkaloids from the venom of Dendrobatoidea Cope, 1865: a scoping review.

#ionchannels @medsky.social #medsky
www.tandfonline.com/doi/full/10....