Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/...
#IonChannels #CardiacMuscle
Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell sub-populations. New study from Claire H. Levitt, Richard K.P. Benninger et al. @cuanschutz.bsky.social:
rupress.org/jgp/article/...
#Pathophysiology #SystemsPhysiology #Diabetes #GabJunctions
Behringer et al. from @tuda.bsky.social show how coarse-grained computational methods uncover long-range mechanical connectivities in HCN #IonChannels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article/...
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
Levitt, Benninger et al. @cuanschutz.bsky.social investigate how loss of #GapJunctions under diabetogenic environments and their protection influence subpopulations of #insulin-producing β-cells rupress.org/jgp/article/...
#Diabetes
Thank you for the thorough, constructive review process!
Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/...
#CardiacMuscle
📄 See a recent JGP paper from Tuan Phan and Daniel Fitzsimons, "Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium" 👉 hubs.la/Q0445GF-0
At JGP, your research is evaluated fairly, edited thoughtfully, and shared with a like-minded community of physiologists. Learn how scientists set the course and publish your next paper 👉 hubs.la/Q0445GC_0
Publishing in JGP enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: rupress.org/pages/nih-hh...
Deep learning as a generator of sodium channel state hypotheses. Lisa Schmidt and Wojciech Kopec @mpi-nat.bsky.social discuss recent work by Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social (rupress.org/jgp/article/...) in Commentary: rupress.org/jgp/article/...
#IonChannels
Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. New study from Catherine Hoover Browne, Henk Granzier and colleagues @uarizona.bsky.social: rupress.org/jgp/article/...
#SkeletalMuscle #CardiacMuscle #MolecularPhysiology #CellularPhysiology #Titin
Sequential membrane remodeling by #cholesterol distinctly modulates HCN channels in naïve & neuropathic DRG neurons. New study by Lucas J. Handlin, Gucan Dai (@gucandai.bsky.social) et al (Saint Louis University School of Medicine): rupress.org/jgp/article/...
#lipids #Biophysics #Pain #IonChannels
📄 See a recent publication in JGP from Phan and Fitzsimons, "Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium" 👉 hubs.la/Q0445GF-0
“This rigorous process ultimately improves the quality of our manuscripts, thereby helps to advance our field of study.” — Dr. Daniel Fitzsimons Learn how scientists set the course at Journal of General Physiology 👉 hubs.la/Q0445GC_0
@gucandai.bsky.social @aubinmoutal.bsky.social
#Cholesterol in cell membranes plays a key role in controlling how #pain-sensing #neurons respond. Handlin et al. show that distinct cholesterol pools—OMD-associated & freely accessible cholesterol—differently influence HCN #IonChannels, which regulate nerve excitability. rupress.org/jgp/article/...
Hoover Browne, Granzier et al. @uarizona.bsky.social report that deleting the P-zone domains A164–167 from #titin in a novel mouse model reveals their critical role in #muscle function and thick filament structure, including maintaining titin’s α and β conformations. rupress.org/jgp/article/...
Opening of rod #photoreceptor CNG channels by photodynamically generated singlet oxygen. New study from Gaogao He, Lei Zhou and colleagues (Shenzhen Bay Laboratory): rupress.org/jgp/article/...
#Biophysics #MolecularPhysiology #IonChannels
📄 See a recent JGP study by Phan and Fitzsimons, "Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium" 👉 hubs.la/Q0445GF-0
“The editors and reviewers ensure that feedback on our work is insightful, intuitive, and informative.”— Dr. Daniel Fitzsimons. Learn how scientists set the course at JGP 👉 hubs.la/Q0445GC_0
#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...
Commentary: Schmidt and Kopec @mpi-nat.bsky.social discuss how Lopez-Mateos et al. @vyy-sf.bsky.social (rupress.org/jgp/article/...) used AlphaFold 2 to generate structural ensembles of voltage-gated sodium channels across different conformations. rupress.org/jgp/article/...
#IonChannels
Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere. New review from Angela C. Greenman, Willem de Lange, and J. Carter Ralphe @wiscpediatrics.bsky.social: rupress.org/jgp/article/...
#CardiacMuscle #Contraction #CellMotility #Biophysics
#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...
Gaogao He, Lei Zhou et al. demonstrate that #ionchannels from #photoreceptors in the retina are very sensitive to photodynamic modification mediated by singlet oxygen, ¹O2, the molecular oxygen in electronically excited states. rupress.org/jgp/article/...
#Biophysics #MolecularPhysiology
📄 See a recent publication in JGP from Phan and Fitzsimons, "Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium" 👉 hubs.la/Q0445GF-0
“We have chosen to submit our work to the Journal of General Physiology because we are confident that the review process will be fair.”— Dr. Daniel Fitzsimons. Learn how scientists set the course 👉 hubs.la/Q0445GC_0
📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers #WSCC26
Greenman et al. review the role of cMyBP-C post-translational modifications in health & disease. During cardiovascular disease, oxidative stress may drive the inverse relationship btwn. phosphorylation & S-glutathionylation of cMyBP-C, identifying new therapeutic targets rupress.org/jgp/article/...