Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. New study from Catherine Hoover Browne, Henk Granzier and colleagues @uarizona.bsky.social: rupress.org/jgp/article/...
#SkeletalMuscle #CardiacMuscle #MolecularPhysiology #CellularPhysiology #Titin
In @jgp.org, Hoover Browne, Granzier et al. report that deleting the P-zone domains A164–167 from #titin in a novel mouse model reveals their critical role in #muscle function and thick filament structure, including maintaining titin’s α and β conformations. rupress.org/jgp/article/...
Hoover Browne, Granzier et al. @uarizona.bsky.social report that deleting the P-zone domains A164–167 from #titin in a novel mouse model reveals their critical role in #muscle function and thick filament structure, including maintaining titin’s α and β conformations. rupress.org/jgp/article/...
🧬 Had a fantastic time at the #MDA Conference in Orlando! I shared some of our work on titin (TTN). Great discussions and new ideas sparked with colleagues working on #titin related myopathies. Excited for what comes next! 💪 #MDAConference @myofinlab.bsky.social @folkhalsanresearch.bsky.social
Are you discarding titin missense variants? You have no idea what you're missing! rdcu.be/e5ZXk #titin #musclediseases #rarediseases @myofinlab.bsky.social @folkhalsanresearch.bsky.social
Trouble in store for muscle fibers. Our latest Research news highlights a new study (doi.org/10.1085/jgp....) from @seongwonhan.bsky.social, Granzier and colleagues: rupress.org/jgp/article/...
#Myofilaments #Titin
So great to see our recent publication featured in the Research News @jgp.org! 💪🔬
#Titin #Muscle #Biomech
The T-wave peak-end to QT ratio is a simple, noninvasive, and readily available test that may predict subclinical, clinically evident DCM in Doberman Pinschers. Open access article: jav.ma/DCM2 #titin #Holter #ECG #dog @ncstatevetmed.bsky.social
Marfan-syndrome cardiomyocytes show excess of #titin isoform N2BA and extended sarcomeric M-band, say Dalma Kellermayer, Cristina Șulea, Miklós Kellermayer, Balázs Kiss and colleagues: rupress.org/jgp/article/...
#CardiacMuscle #Contraction #Myofilaments
Intrinsic cardiomyopathy is an emerging cause for heart failure in #MarfanSyndrome. Kellermayer, Șulea, Kellermayer, Kiss et al. uncover a #titin isoform shift in Marfan-syndrome heart samples, which may serve as an adaptation mechanism in this severe disease. rupress.org/jgp/article/...
Fact: The longest word in the English language is 189,819 letters long. 😵💫 It’s the chemical name for the protein known as titin. Saying this word would take about three and a half hours! ⏳
#facts #fact #didyouknow #english #longest #titin
After a long process, I will soon have a paper out at PNAS that explores the molecular mechanisms of residual force enhancement using some cool mouse models and small-angle Xray diffraction. It is not just about titin-based forces, per se, but they run the show 😎. Details OTW #titin #MuscleScience
