Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. New study from Catherine Hoover Browne, Henk Granzier and colleagues @uarizona.bsky.social: rupress.org/jgp/article/...
#SkeletalMuscle #CardiacMuscle #MolecularPhysiology #CellularPhysiology #Titin
Prepulse facilitation of the honey bee Caᵥ4 channel is produced by a shift in channel activation and requires an intact inactivation sequence. New study from Thierry Cens, Pierre Charnet and colleagues @ibmm-balard.bsky.social: rupress.org/jgp/article/...
#Biophysics #CellularPhysiology
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic #bradycardia. New study from Luca M.G. Palloni, Dario DiFrancesco and colleagues (University of Milano): rupress.org/jgp/article/...
#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current. New study from Antonella Dapino and Sebastián Curti (Universidad de la República, Uruguay) rupress.org/jgp/article/...
#CellularPhysiology #IonChannels #GapJunctions
Electrical synapses enable neural circuits to perform as coincidence detectors. Dapino and Curti show that the temporal precision of this operation is critically determined by voltage-dependent conductances of the soma and proximal axon. rupress.org/jgp/article/...
#CellularPhysiology #IonChannels
β2 and β3a regulatory subunits can coassemble in the same BK channels, say Yu Zhou, Christopher Lingle (@chris-lingle.bsky.social) and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
Mn quenching in activated #zebrafish muscle fibers does not result from store‐operated Ca entry, say Francisco Jaque-Fernandez, Bruno Allard and colleagues (Université Claude Bernard, @cnrs.fr): rupress.org/jgp/article/...
#CellularPhysiology #SkeletalMuscle
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture, say Leander Vonk, Osman Esen, Tyler Kirby @kirbylab.bsky.social and colleagues @amsterdamumc.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #SkeletalMuscle
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture, say Leander Vonk, Osman Esen, Tyler Kirby and colleagues @amsterdamumc.bsky.social: rupress.org/jgp/article/...
#CellBiology #CellularPhysiology #Contraction #SkeletalMuscle
A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. New study from Sho Horie, Katsunori Kitano, Masao Tachibana, Chieko Koike and colleagues (Ritsumeikan University): rupress.org/jgp/article/...
#Neuroscience #Pathophysiology #CellularPhysiology
#SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1, say Aishwarya Chandrashekar, Leigh Plant and colleagues @nubouve.bsky.social: rupress.org/jgp/article/...
#Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology
Kinetics of aldosterone-dependent ENaC trafficking in the kidney. New study from Gustavo Frindt, Lawrence Palmer (Weill Cornell Medicine) and colleagues: rupress.org/jgp/article/...
#CellularPhysiology #MolecularPhysiology #MembraneTransport
GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains, say Rebeca Martínez-Lázaro, David Bartolomé-Martín, Teresa Giraldez et al. @ull.es rupress.org/jgp/article/...
#Biophysics #CellularPhysiology #IonChannels
Variability in reported midpoints of (in)activation of cardiac Ina. New study from Michael Clerx @michaelclerx.com, Paul Volders, and Gary Mirams @mirams.bsky.social @uniofnottingham.bsky.social: rupress.org/jgp/article/...
#ComputationalBiology #CardiacMuscle #CellularPhysiology #IonChannels
Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons, say Joseph Ransdell, Jeanne Nerbonne and colleagues @washumedicine: rupress.org/jgp/article/...
#Nerve #Pathophysiology #CellularPhysiology
FGF14 encodes a sodium channel accessory subunit. In @jgp.org, Ransdell, Nerbonne et al. @washumedicine.bsky.social show that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects. rupress.org/jgp/article/...
#Nerve #CellularPhysiology
FGF14 encodes a sodium channel accessory subunit. Ransdell, Nerbonne et al. @washumedicine.bsky.social show that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects. rupress.org/jgp/article/...
#Nerve #CellularPhysiology
Connect with peers and pioneers to debate membrane contact site research at EMBO Workshop "Membrane Contact Sites: Methodology, Biology & #Pathology" in Monopoli, Italy, 28 Sep–3 Oct 2025
Deadline: 30 Apr
meetings.embo.org/event/25-mem...
#EMBOmembraneContacts #CellularPhysiology #EMBOevents 🧪
🤖Tune in to our conference on #AI and #CellularPhysiology starting Sunday at 8 pm ET🦠
Registration ➡️ janelia.news/register
Mark your calendar for our upcoming interdisciplinary conference on the intersection of #AI & #CellularPhysiology.
Join us, via Zoom, March 30 - April 1 to watch talks & discussions from leaders as they discuss the challenges & opportunities posed by these fields.
Register: janelia.news/register
Are you—or someone you know—exploring the crossroads of #AI and #CellularPhysiology?
@hhmijanelia.bsky.social is hosting a free, live-streamed conference March 30 - April 1, diving into the latest AI-driven advances in biological research.
Join via Zoom—register now: janelia.news/register
📢 #AI & #CellularPhysiology researchers 👉 tune in via Zoom March 30-April 1 for a free livestream of our conference on the emerging intersection of AI and biological research.
Topics will range from AI-driven genomic insights to dataset challenges & more.
🔗Register to watch: janelia.news/register
