Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Sonya Marshall-Gradisnik et al. 🇦🇺
#ME/CFS #TRPM3 #IonChannel #NKcells
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Hashtag
#IonChannel
Advertisement · 728 × 90
🔬Ion Biosciences delivers a powerful suite of sensitive fluorescence based #ionchannel assays, including calcium, sodium, potassium & non- specific channels, designed for robust, reliable HTS in #drugdiscovery
👉 www.stratech.co.uk/our-partners/ion-bioscie...
#FluorescenceAssays #hts
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Call For Papers | Special Issue on Mathematical Modeling for Ion Channels
Submission deadline: March 31
#Entropy #Paper #Collection #Modeling #IonChannel #Neuroscience ./17
www.complexitycat.org/posts/entrop...
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#CallForPapers ⏰️ Don't miss the March 15th deadline! Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery 👉 rupress.org/JGP/pages/ca...
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Ramon Latore treats the audience to an inspirational retrospective on the operation of BK Channels as the Keynote Speaker at the #BPS2026 Satellite Meeting on Drug Discovery.
A fitting kickoff to a week of #science 🧪 #biophysics #ionchannel in SF!
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After a safe, even if long, travel to SF yesterday, I am so looking forward to peeking into new discoveries, forging a positive future, reconnecting with brilliant minds, and making new friends.
If you are at #BPS2026, come say hello, and make my day 🥰!!
#science 🧪 #biophysics #ionchannel #bps2026
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Happy birthday to #LaskerLaureate Roderick MacKinnon! He was recognized for the elucidation of the structure & function of potassium channels, providing the first molecular description of a selective #ionchannel. 🧪
The Rockefeller University
📖 https://ow.ly/EC6Y50YhWnc
🎧 https://ow.ly/Pcw150YhWn8
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📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
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📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
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Easily detect & quantify changes in #ionchannel activity using #FlowCytometry
ION Biosciences Flow Cytometric Potassium Channel Assay is the first assay solution for #SingleCell, high throughput measurements of #potassiumchannel activity
👉https://tinyurl.com/83j3fc7m
#neuroscience #microbiology
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Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Sonya Marshall-Gradisnik et al. 🇦🇺
#ME/CFS #TRPM3 #IonChannel
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Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp
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New from our lab: More evidence that ion channels play a key role in high-grade glioma and represent promising therapeutic targets.
🔗 link.springer.com/article/10.1...
🔗 academic.oup.com/neuro-oncolo...
#highgradeglioma #ionchannel #braincancer
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Not that new, but worth a post - a nice calcium binding site in the pore of the trimeric Bile Acid Sensing #ionchannel BASIC.
www.nature.com/articles/s41...
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New review highlights emerging insights into KCNE–Kv channel interactions, their organ-specific roles, and how these discoveries may drive next-generation therapies for #IonChannel disorders. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
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Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
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Interesting #IonChannel story about an enzyme removing burn-inducing compounds from spirits.
www.wired.com/story/booze-...
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🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
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Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
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Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
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Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
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Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology
physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience
www.nature.com/articles/s41...
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A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications
www.nature.com/articles/s41...
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Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
www.nature.com/articles/s41...
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Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications
www.nature.com/articles/s41...
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A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42...
Open access
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New in @jgp.org: Zangerl-Plessl, Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social
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Eva-Maria Zangerl-Plessl, Sun-Joo Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social
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