The May issue is now online!

👉 Read our latest articles:
onlinelibrary.wiley.com/toc/13652796...

#oncology #tumors #immunotherapy #epigenetic #T1D #pregnancy #HLA #CIPO #gastrointestinal #gaucher #GD1 #pheochromocytoma #paraganglioma #cholesterol #ColorectalCancer #screening #ataxia #ITPR1

Scientists Discover Cancer Tumors Are “Addicted” to This Common Antioxidant Cancer cells may be exploiting a common antioxidant as fuel, revealing a potential weakness that future therapies could target. Cancer cells may be tapping into an unexpected energy source: an antioxi...

#Scientists Discover #Cancer #Tumors Are “Addicted” to This Common #Antioxidant

scitechdaily.com/scientists-d...

What Would Real #Energy #Independence Look Like? : Medium

#Artemis II Has Launched. Here's Everything You Need to Know About This #Mission to the #Moon : Time

Turning on an #Immune pathway in #Tumors could lead to their #Destruction : Tech Review

knowledgezone.co.in/resources/bo...

Scientists find a #new #therapeutic #target present on up to half of all #tumors

Researchers at UCSF have discovered that the SRC enzyme also appears like a flag on the surface of bladder, colorectal, breast, pancreatic etc - for antibody targeting scitechupdates.com/s...

Promising new approach from @mskcancercenter.bsky.social : uPAR-targeted #CARTcells tackle both #tumor cells and their microenvironment, showing strong preclinical activity in solid #tumors and #metastases. www.linkedin.com/posts/drmelv...

Practical recommendations to strengthen cancer microbiome research An international team led by researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) and A*STAR Genome Institute of Singapore (A*STAR GIS), has published…

Recommendations to strengthen #cancer #microbiome research ...

| #tumors | #microsky | #microbes | #sequencing | #DNA | Via @sciencex.bsky.social

Engineering NK and T cells with metabolite-sensing receptors to target solid tumors - Nature Immunology Here the authors use CRISPR activation screens to identify metabolite-sensing receptors that affect lymphocyte targeting and infiltration of tumors and engineer CAR T and CAR NK cells with these recep...

Engineering #NK and #T_cells with #metabolite-sensing receptors to target #solid #tumors: www.nature.com/articles/s41...

HPV-positive cancers hide from the immune system, but blocking a single protein could make the tumors treatable A team of scientists at Henry Ford Health + Michigan State University Health Sciences have uncovered a mechanism that allows certain head and neck cancers to hide from the immune system, a discovery…

#HPV-positive #cancers hide from the immune system ...

| #HumanPapillomavirus | #ImmuneSystem | #tumors | #microbiology | #virology | By @michiganstateu.bsky.social via @sciencex.bsky.social

UCLA researchers engineer CAR-T cells to target hard-to-treat solid tumors UCLA scientists have developed a next-generation CAR-T cell therapy that can overcome the immunosuppressive tumor microenvironment, a protective shield that tumors use to weaken immune cells, block th...

#UCLA researchers (Dr. Chen) engineer #CAR_T cells to target hard-to-treat solid #tumors (like brain cancer): stemcell.ucla.edu/news/ucla-re...

#Pesticides #EnvironmentalJustice #HealthRisk #Pregnancy #BlackWomenReproductiveHealth #ReproductiveHealth #Tumors #DCPA #Produce #Contamination

@labsoap.bsky.social proud to take part in #BrainAwarenessWeek @semaineducerveau.bsky.social , where we engaged with the public on the topic of #brain #tumors
It was a great opportunity to share our research and raise awareness about the challenges and advances in this field.

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering T cells are often weakly responsive to tumor self-antigens because of central tolerance, constraining their ability to eliminate tumors. We exploited mechanical force to engineer a weakly reactive T…

Catch-bond interactions are not easy to grasp compared to affinity and specificity. How are they measured, and is the approach reproducible?

#science
#immunology
#tumors
#immunotherapy

www.science.org/doi/10.1126/...

Cancer’s Deadly Paradox: How Tumors Break Their Own DNA To Keep Growing Cancer’s strongest gene switches push DNA into damaging overdrive, creating repeated breaks and repairs that may fuel tumor evolution while exposing possible therapeutic weak spots.

#Cancer’ s Deadly Paradox:
How #Tumors Break Their Own #DNA To Keep Growing

scitechdaily.com/cancers-dead...

Schematic of the strategy for introducing the optimized romidepsin/FK228 biosynthetic pathway into the probiotic bacterial strain Escherichia coli Nissle 1917 (EcN), aimed at biosynthesis and tumor-targeting delivery of FK228 to achieve anticancer activity.

Bacteria-mediated #cancer therapy uses bacterial strains to colonize #tumors & deliver therapeutic molecules. This study engineers E. coli Nissle 1917 strains to make & deliver the drug #romidepsin (FK228), achieving improved efficacy & reduced systemic toxicity @plosbiology.org 🧪 plos.io/3NadfQv

Schematic of the strategy for introducing the optimized romidepsin/FK228 biosynthetic pathway into the probiotic bacterial strain Escherichia coli Nissle 1917 (EcN), aimed at biosynthesis and tumor-targeting delivery of FK228 to achieve anticancer activity.

Bacteria-mediated #cancer therapy uses bacterial strains to colonize #tumors & deliver therapeutic molecules. This study engineers E. coli Nissle 1917 strains to make & deliver the drug #romidepsin (FK228), achieving improved efficacy & reduced systemic toxicity @plosbiology.org 🧪 plos.io/3NadfQv

Schematic of the strategy for introducing the optimized romidepsin/FK228 biosynthetic pathway into the probiotic bacterial strain Escherichia coli Nissle 1917 (EcN), aimed at biosynthesis and tumor-targeting delivery of FK228 to achieve anticancer activity.

Bacteria-mediated #cancer therapy uses bacterial strains to colonize #tumors & deliver therapeutic molecules. This study engineers E. coli Nissle 1917 strains to make & deliver the drug #romidepsin (FK228), achieving improved efficacy & reduced systemic toxicity @plosbiology.org 🧪 plos.io/3NadfQv

Exciting engineered bacterial #drugdelivery research from @baylor.bsky.social. Turning #bacteria into drug couriers is a bold and promising leap for #cancer therapy. Targeted intracellular delivery like this could redefine how we treat hard-to-reach #tumors. www.linkedin.com/posts/drmelv...

Targeting KRAS-driven precancerous pancreatic lesions before #tumors form could redefine early intervention strategies for pancreatic ductal adenocarcinoma PDAC - one of the deadliest #cancers. Important work from @pennmedicine.bsky.social Abramson Cancer Center www.linkedin.com/posts/drmelv...

Painless Procedure: Tiny Ice Ball Kills Tumors In Minutes IceCure's tech allows physicians to remove tumors at their own office with no need for hospitalization - using liquid nitrogen and ice.

A medical breakthrough now allows doctors to freeze early-stage #breast #tumors – with #no #surgery, no #scarring,
no general #anesthetic and no tissue removal.

IceCure's #tech allows #physicians to remove tumors at
their own office with no need for #hospitalization.

nocamels.com/2023/01/pain...

#Immunity to a common #virus could help treat #tumors ...

| #peptides | #cancer | #immunotherapy | #cytomegalovirus | Via the-scientist .com

Beamion PANTUMOR-1: rationale and design of a Phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid tumors Human epidermal growth factor receptor 2 (HER2, encoded by ERBB2) alterations are known oncogenic drivers in many solid tumors. Zongertinib is a novel, oral, irreversible, HER2-selective tyrosine k...

Beamion PANTUMOR-1: rationale and design of a Phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid #tumors www.tandfonline.com/doi/full/10.... #hvhebron #onco

Smart strategy by Institute of Science Tokyo researchers: targeting ASCT2 instead of LAT1 could significantly expand the reach of Boron Neutron Capture Therapy BNCT to #tumors previously resistant to treatment. www.linkedin.com/posts/drmelv...

Great work by Duke-NUS #Singapore researchers showing how #pancreaticcancer cells switch between treatment-sensitive and resistant states. Targeting the KRAS-ERK pathway to restore GATA6 and re-sensitize #tumors to #chemotherapy could be a promising strategy. www.linkedin.com/posts/drmelv...

A #disulfidptosis-based model for #HeadAndNeckCancer predicts survival and links low-risk #tumors to stronger immunity, while #multiomics highlight CXCL12–CXCR4 and identify #NQO1, with #dicoumarol boosting checkpoint therapy.

#OpenAccess: doi.org/10.1016/j.ge...

Bacteria Engineered to Eat Tumors From the Inside Researchers say they've developed a new way to treat cancer by engineering bacteria to eat tumors from the inside out.

#Bacteria Engineered to Eat #Tumors From the Inside

futurism.com/health-medic...

Engineered bacteria can eat cancer tumors from the inside Cancer treatments such as surgery, chemotherapy, and radiation have saved many lives, but they also have limits and side effects. Scientist...

#Cancer #Engineered #bacteria #can #eat #cancer #tumors […]

[Original post on knowridge.com]

Microplastics Discovered in Prostate Tumors A NYU Langone study found microplastic in prostate tumors, suggesting a link between plastic and risk for prostate cancer. Learn more.

nyulangone.org/news/micropl... #microplastics #tumors #cancer

Classifying pediatric brain tumors by liquid biopsy using artificial intelligence See how M-PACT, an AI-powered algorithm can sift through ctDNA in cerebrospinal fluid and molecularly classify tumors based on their DNA methylation pattern

Classifying #pediatric #brain #tumors by liquid biopsy using #ArtificialIntelligence

www.stjude.org/media-resour...

#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

Killing cancer cells with RNA therapeutics – BioNews Central A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects

A new study in mice hints at the potential to use tiny #RNANanoparticles to deliver #ChemotherapyDrugs and other therapies directly to #tumors, killing #CancerCells without generating an immune response or toxicity-related #SideEffects. 
#RNATherapeutics #CancerTherapy

Clonal determinants of organotropism and survival in metastatic uveal melanoma - npj Precision Oncology npj Precision Oncology - Clonal determinants of organotropism and survival in metastatic uveal melanoma

Researchers at Yale Medicine identified #biological markers for a rare and aggressive eye #cancer. These markers could predict the likelihood of secondary #tumors forming in the liver, resulting in new opportunities for monitoring the progression.
www.nature.com/articles/s41...