A #disulfidptosis-based model for #HeadAndNeckCancer predicts survival and links low-risk #tumors to stronger immunity, while #multiomics highlight CXCL12–CXCR4 and identify #NQO1, with #dicoumarol boosting checkpoint therapy.

#OpenAccess: doi.org/10.1016/j.ge...

NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in Hepatocellular Carcinoma

Researchers identify NQO1 overexpression as a driver of #lenvatinib resistance in #HepatocellularCarcinoma by reducing ROS and blocking #apoptosis, and show that combining lenvatinib with the NQO1 inhibitor #dicoumarol reverses resistance.
Read: doi.org/10.1007/s115...

#NQO1 ameliorates #lenvatinib-mediated #apoptosis by suppressing #ROS levels, resulting in lenvatinib resistance in HCC cells, which can be reversed upon co-treatment with #Dicoumarol, an NQO1 inhibitor. #medsky

#OpenAccess: link.springer.com/article/10.1...