Engineering NK and T cells with metabolite-sensing receptors to target solid tumors - Nature Immunology Here the authors use CRISPR activation screens to identify metabolite-sensing receptors that affect lymphocyte targeting and infiltration of tumors and engineer CAR T and CAR NK cells with these recep...

Engineering #NK and #T_cells with #metabolite-sensing receptors to target #solid #tumors: www.nature.com/articles/s41...

New Insights into Omalizumab's Role in Modulating T Cell Responses to Food Allergens Recent studies unveil how Omalizumab influences T cell mechanisms, enhancing thresholds for food allergy reactions. Discover its potential benefits.

New Insights into Omalizumab's Role in Modulating T Cell Responses to Food Allergens #United_States #Philadelphia #Food_Allergies #Omalizumab #T_Cells

Episode 21: A role for T cells in flavivirus vaccination and pathogenesis | Creating Memory: Vaccines & Immunity We talk with Dr. Annie Elong Ngono, a research instructor in the Center for Vaccine Innovation at the La Jolla Institute for Immunology, CA, who studies the role of T cells in vaccine-mediated protect...

Check out our interview with our next 'Rising Star' Dr. Annie Elong Ngono who works on understanding the protective and pathogenic roles of #T_cells during #flavivirus (#DENV and #ZIKV) vaccination and infection. cvimp.podbean.com/e/episode-21...

Therapeutic T cells with synthetic gene circuits act locally - Nature Biotechnology Nature Biotechnology - Therapeutic T cells with synthetic gene circuits act locally

Therapeutic #T_cells with synthetic #gene #circuits act locally: www.nature.com/articles/s41...

Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion The balance of T cells in a progenitor-exhausted state and those in a terminally exhausted state is a critical determinant of anti-tumor responses. Waibl Polania, Hoyt-Miggelbrink, et al. identify antigen presentation and tumor-associated macrophages (TAMs) as key drivers of counterproductive skews toward terminal exhaustion in solid tumors. TAM depletion restores this balance and enhances immunotherapeutic responses.

#T_Cells #cancer #brain_tumor #pathways

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T cell exhaustion is severe in glioblastoma making an important model tumor for studying the dynamics of and contributors to T cell exhaustion.

www.cell.com/immunity/ful...

Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells Interplay between signaling pathways and ribosomal biogenesis supports the proliferation of activated T cells.

Reciprocal regulation of #mTORC1 signaling and #ribosomal biosynthesis determines #cellcycle #progression in activated #T_cells: www.science.org/doi/10.1126/...