Check out this new @natprot.nature.com study!

Dr. Chiara Lago and scientists at the University of Trento have enabled robust generation and drug testing of patient-derived pediatric brain tumor organoids.

📄 https://go.nature.com/4m6iTA3
🎧 https://bit.ly/425e7JH

Scientists led by Dr. @joshifrenster.bsky.social at @upf.edu have discovered that cell competition in gastruloids is stage-specific and driven by relative p53 levels during pluripotency exit.

📄 Read more: https://go.nature.com/41YmuXt
🎙️ Listen now: https://bit.ly/425e7JH

📣 New episode alert!

Dr. Kotaro Sasaki (@kotaro-sasaki.bsky.social) from @upenn.edu joins us to discuss how his lab uses human pluripotent stem cells to model germ cell development and endocrine organs such as the testis and adrenal gland.

🎧 Tune in: https://bit.ly/425e7JH

Widely recognized as one of the leading life scientists of her generation, Dr. Regev is a pioneering computational & systems biologist whose work has reshaped modern biology. Dr. Regev will give a keynote address at #ISSCR2026.

Register to hear her talk! https://www.isscr2026.org/

Wyss Institute technologies enable breakthrough in astronaut health research aboard NASA’s Artemis II mission By Alexandra Jirstrand (BOSTON) – Launched on April 1, 2026, Artemis II is a historic, approximately 10-day lunar flyby mission that is sending four astronauts farther into space than any humans have traveled since the Apollo era, marking a critical step toward sustained lunar exploration and future missions to Mars. The Wyss Institute for Biologically...

For NASA’s Artemis II mission, Wyss scientists sent Organ Chip "avatars" made from astronaut cells into deep space. These chips mimic bone marrow function & will help researchers understand how space travel affects the body. Findings could contribute to biomedical advancements for patients on Earth.

Is the "relocation rule" real? 🧳

If you’re weighing a postdoc move, considering a faculty position, or thinking strategically about long-term independence, the latest episode of Lab Coats & Life™ Podcast offers a grounded and practical perspective. #GradLife

The Global Stem Cell Event – the #ISSCR2026 Annual Meeting, is getting closer! 📆

Join nearly 3,500 scientists, clinicians, and industry leaders in Montréal for four days at the frontiers of stem cell science, regenerative medicine, and engineering biology.

Register now: ISSCR2026.org

Researchers identify DOT1L, a histone methyltransferase, as a key #epigenetic regulator of endothelial-to-mesenchymal transition and fibrotic progression.

They highlight DOTL1 as a potential therapeutic target in fibrotic lung disease. 🫁

🎯 https://bit.ly/41irWUT

I illustrated my way through the @bsdb.bsky.social Spring Meeting a couple weeks ago - here's my illustrated summary of the conference! I sketched (almost) all the speakers and glimpses of the science that made it such a great few days.

🧬 Sea Lamprey (Petromyzon marinus) ✨ A window into early vertebrate evolution! 🧠 Lampreys help reveal how key vertebrate features, like neural crest cells, the vertebrate brain, and craniofacial structures originated and diversified 📸 Image by David Jandzik #ModelMonday #DevBio #EvoDevo #Lamprey

Dr. Mansi Srivastava and Amber Rock at @mczharvard.bsky.social have shown that #embryos of the acoel Hofstenia miamia retain unexpected totipotency and high developmental plasticity even after early fate-specifying cleavages.

🔬 https://bit.ly/4cebT0t
🎙️ https://bit.ly/4sKXLlt

Through epigenetic profiling of patient-derived #organoids, scientists have shown distinct #BreastCancer subtypes, offering new insights into disease progression and potential therapeutic targets.

🔗 https://bit.ly/4t9FE8k
🎧 https://bit.ly/4sKXLlt

Check out this @cellpress.bsky.social paper! 👇

It identifies sildenafil as a potential treatment for #LeighSyndrome, showing it improves mitochondrial function, disease phenotypes, and patient outcomes.

🗞️ https://bit.ly/4rAuTe6
🎧 https://bit.ly/4sKXLlt

In a recent @natcomms.nature.com study, scientists led by Dr. Dennis Tappe and Stephanie Jansen demonstrate that human #CerebralOrganoids effectively model West Nile virus #encephalitis and its associated neuronal damage and inflammation.

🔬 https://go.nature.com/40lKdjS
🎧 https://bit.ly/4sKXLlt

Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

📢 New episode!

We chat with Dr. Aitor Aguirre (@aaguirre1980.bsky.social) from Michigan State University about how his lab uses pluripotent stem cells and #CardiacOrganoids to model human heart development and disease.

🎧 Listen now: https://bit.ly/4sKXLlt

Synthetic biology makes fateful decisions By Jia LIU, Chinese Academy of Sciences Edited by Karen Pepper (BEIJING) – Cellular differentiation and a division of labor are essential to living systems as distinct cell types performing specialize...

Researchers developed a recombinase-based programmable platform for cell differentiation & proportion control. This work (@nature.com) establishes a rational framework for constructing multicellular systems, applicable to engineered living materials, organoid assembly, & biomanufacturing.

RNA-Sequence Analysis Workshop

🗣️ Trainees interested in learning how to analyze bulk and single-cell RNA-seq data?

Applications are open for SCN’s RNA-seq Analysis Workshop, a virtual training opportunity focused on RNA-seq data acquisition and analysis.

Apply. ➡️ stemcellnetwork.ca/training/rna-seq-analysi...

PLN accumulates in aged PLN R14del zebrafish hearts, which is resolved by fasting-induced lysosomal activation

I am happy and excited to share our latest preprint on PLN cardiomyopathy:
www.biorxiv.org/cgi/content/...

We found that PLN R14del cardiomyocytes have lysosomal dysfunction resulting in PLN accumulation, microtubule remodelling and structural defects, which are rescued by lysosomal reactivation.

Did you know Arun also co-hosts the Lab Coats & Life Podcast?

In the latest episode, he talks with Euan Adie, Founder of
@altmetric.com, about rethinking how we measure research impact beyond traditional citations. 👇

#altmetrics

Walk With Me: Paul Mischel, physician-scientist studying cancer evolution YouTube video by Stanford Medicine

Walk with Me: Meet Paul Mischel, who studies how cancer cells grow, evolve, and resist treatment. His lab has uncovered key drivers of aggressive cancers. Discover what led him to this work — and his favorite comfort meal. youtu.be/SlPd-Pdvs-k?...

@stanford-cancer.bsky.social

Can a mouse be cloned indefinitely? Decades-long experiment has answers Repeated cloning from a single mouse failed after 58 generations. Researchers say harmful DNA changes are to blame.

After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned

go.nature.com/3Pue5Iz

Scientists led by Dr. Maurilio Sampaolesi at KU Leuven have generated #HeartOrganoids from Duchenne #MuscularDystrophy patient stem cells that mimic cardiomyopathy.

📄 Read the study: https://bit.ly/4l2pMC5
🎧 Listen to the discussion: https://bit.ly/46XtIy5

Amniogenesis in embryos and stem cell models - Nature Cell Biology This Review discusses the mechanisms underlying both cavitation and folding amniogenesis and provides an overview of the various recent stem cell-based human embryo models that have been developed to ...

☕New Review article discussing the mechanisms underlying both cavitation and folding #amniogenesis, as well as various recent stem cell-based human #embryo models developed to elucidate amniotic formation and function.
👉https://rdcu.be/e9wos
bit.ly/4uGeh7v

In our latest episode, we discuss how #BloodStemCells briefly ramp up differentiation after #chemotherapy to rebuild the blood system before returning to their normal state.

👓 Read the study: https://bit.ly/4roZVWg
🔊 Listen to the discussion: https://bit.ly/46XtIy5

First 24 hours of embryonic development in 9 different animal species: (From left to right) Zebrafish, Sea urchin, Black widow spider, Tardigrade, Sea squirt, Comb jelly, Parchment tube worm, Roundworm, Slipper snail. Credit to @tessamontague.bsky.social & Zuzka Vavrušová. #ZebrafishZunday #devbio 🧪

New work led by Dr. Ibrahim El-Battrawy at Ruhr University Bochum shows that mutations in SLC4A3 raise intracellular pH in heart cells, which shortens electrical signals and increases the risk of dangerous #arrhythmias. 🫀

📄: https://bit.ly/4uEnb5E
🎧: https://bit.ly/46XtIy5

Walk With Me: Seung Kim, developmental biologist studying diabetes YouTube video by Stanford Medicine

Walk With Me: Seung Kim studies pancreatic biology and insulin-producing cells to advance regenerative approaches for diabetes. Hear what still inspires him about science -- and why Elvis Presley is on his lab walls. www.youtube.com/watch?v=zrZQ...

This week, we discuss a study from the lab of Dr. Trista North (@tristanorth.bsky.social!

It shows that #HSPCs expand while staying multipotent thanks to tightly controlled ROS levels regulated by developmental #mitophagy.

📄 https://go.nature.com/4tWuJ3e
🎧 https://bit.ly/46XtIy5

📢 A new episode is out!

We chat with Dr. Thorsten Boroviak (@boroviak.bsky.social) about how stem cell–based #EmbryoModels are helping researchers study early human and #primate development.

🎧 Listen now: https://bit.ly/46XtIy5