a comic book-style drawing of a purple villain saying "FibroooooBLAST" and firing a ball of energy (and fibers) from their hand

I turned a cell type into a comic book style super villain!

#comic #fibroblast #supervillain

Excellent seminar by Dr. Kory Lavine during his visit to our center yesterday, sharing important insights into #IL1B in #fibroblast biology, and mechanisms of #HeartFailure. Great science and stimulating conversations.

Stimulating Fibroblasts for Better Skin Texture
Stimulating fibroblasts supports natural collagen & elastin production, helping improve skin texture, firmness, and overall smoothness while encouraging healthier, more resilient skin over time.
meiraderm.com/services/fib...

#Fibroblast #HealthySkin

#Research
Uridine-Cytidine Kinase 2 (#UCK2)/Uridine-Cytidine Kinase Like 1 (#UCKL1) complex exacerbates the differentiation of myocardial fibroblasts via #TRIM21/#Smurf2/#Smad3 pathway after myocardial infarction doi.org/10.1186/s435...

#Myocardial #Infarction #fibroblast

Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications Single-cell sequencing has elucidated cell-type-specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin-associated genetic mech...

#Review in #MedComm
Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications doi.org/10.1002/mco2...

#EpithelialCell #fibroblast #ImmuneCell #IPF #scRNA_seq #SpatialTranscriptomics

#scRNAseq identifies #prolactin signaling as a key driver of #adenomyosis, revealing PRLR overactivation in #epithelial and #fibroblast subclusters, and shows that PRLR blockade with HMI-115 markedly alleviates disease. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

This review outlines how EV-ncRNAs drive #PreMetastaticNiche formation by shaping #immunosuppression, #VascularRemodeling, #inflammation, metabolism, and #fibroblast activation across #cancers, highlighting their promise as #biomarkers.

#OpenAccess: doi.org/10.1016/j.ge...

Thrilled to share our work that has indeed *complemented* ongoing research in the lab!!!🙌
#complement #IL33 #fibroblast #ILC2 #airwayallergy

Anti-aging Effects of Alu Antisense RNA on Human Fibroblast Senescence Through the MEK-ERK Pathway Mediated by KIF15

This study identifies Alu #AntisenseRNA (asRNA) as a key regulator of senescent #Fibroblast proliferation via the #KIF15–MEK–ERK signaling pathway, highlighting Alu #asRNA as a promising #NucleicAcidDrug candidate for combating #HumanSkin #Aging. #medsky

To read: link.springer.com/article/10.1...

#Senescence #Mechanobiology

Human adult lung #Fibroblast undergoes spontaneous #Senescence on soft, viscoelastic hydrogel

Norbornene-modified #HyaluronicAcid▶️
#Stiffness
β-cyclodextrin-modified #HyaluronicAcid▶️
#Viscoelasticity

Likely #YAP independent

bioRxiv 2025
www.biorxiv.org/content/10.1...

E3 ligase CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation - M... Myocardial fibrosis is a serious complication in sepsis and leads to cardiac dysfunction. The carboxy terminus of Hsc70-interacting protein (CHIP), a U-box E3 ligase, defends against sepsis-caused car...

#Research
E3 ligase #CHIP restoration facilitates the effect of α1-adrenoceptor blockage on alleviating #lipopolysaccharide-caused cardiac fibrosis via downregulating TGF-BR1 expression and Smad2/3 activation doi.org/10.1186/s435...

#Norepinephrine #CardiacFibrosis #Fibroblast

From the September issue: A #fibroblast population that could help us improve #skingraft survival www.jidinnovations.org/article/S2667-0267(25)00... #medderm #dermsky

We are pleased to host @shouval.bsky.social at #KSStromal26.

Her team studies how tumours reprogram the local microenvironment to enable systematic malignancies. One of the way tumours predominantly do this is by interacting with #fibroblast.

Register now to hear more! keysym.us/KSStromal26

Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart | Circulation BACKGROUND: In patients surviving myocardial infarction, adipose tissue infiltration within the scar is a common pathological finding and has been suggested to contribute to dysfunction and arrhythmog...

Very interesting paper from the Frangogiannis’s lab — #Fibroblast -Specific Loss of #TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted #Heart (and cardiac rupture) www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @einsteinmededu.bsky.social

🍬Extracellular glucose triggers metabolic reprogramming of cultured human bronchial epithelial cells and indirect fibroblast activation

🔗https://buff.ly/45XpXXB

🥼 @lipiditsaso.bsky.social

#GlucoseMetabolism #Fibroblast #MetabolicReprogramming

Couldn’t have done this without Emilio’s hard work 🎉 Huge thanks to our amazing co-authors, collaborators, and @CIHR for supporting this fundamental research! #Zebrafish #Fibroblast #CellMigration #Chemoattraction #DevBiol 8/8

#BALR2025 🫁 @cardiffuni.bsky.social what a fantastic 3 days 👏 lovely to see everyone and to present some #fibroblast data updates 🤗 Really high standard from all #ECRs and great #flashtalks #posters #presentations. Superb keynote from @tatalab-duke.bsky.social thanks @balrcommunity.bsky.social

Top: Transgenic expression of PdgfraΔK-EGFP (cyan) in nkx3.1:Gal4; UAS:NTR-mCherry (magenta) background at 56 hpf. mCherry+ EGFP+ cells are mostly restricted in the dorsal or ventral regions of the trunk. A transverse view of a 50 μm region centered on the dashed line is shown on the right, with the neural tube (nt) and notochord (n) outlined by dotted lines. Bottom: Model for how the migration of sclerotome-derived cells is regulated by chemoattraction mediated by Pdgfab/Pdgfra signaling. (A) In wild-type embryos, nkx3.1+ (cyan) sclerotome-derived cells express the receptor Pdgfra (magenta), while the medial somites express the ligand Pdgfab (orange) in response to Hh signaling. pdgfra+ sclerotome-derived cells undergo extensive migration toward both the notochord in the medial trunk and the fin fold. (B) In pdgfra−/− mutants (pdgframRFP/mRFP and pdgfraref/ref), nkx3.1+ sclerotome-derived cells fail to migrate in any direction and remain in their original location in the ventral and dorsal parts of the somites. (C) In pdgfab−/− embryos, pdgfra+ sclerotome-derived cells fail to migrate toward the notochord, although migration toward the fin fold remains unaffected. (D) In pdgfab−/− embryos with mosaic pdgfab expression, nkx3.1+ sclerotome cells can migrate toward the ectopic pdgfab-expressing cells, either medially around the notochord or ventrally toward the yolk extension. When the pdgfab source is located near or in the notochord, it can completely rescue the migration of nkx3.1+ sclerotome cells toward the notochord. These diagrams depict a 2-somite region located above the yolk extension of a zebrafish embryo at 48 hpf. nt: neural tube; n: notochord.

What guides fibroblast precursors' migration from the #sclerotome during vertebrate development? @penghuang031.bsky.social &co show that this is driven by #PDGF -mediated chemoattraction, enabling their differentiation into specialized #fibroblast subtypes @plosbiology.org 🧪 plos.io/3HTZ92Y

Top: Transgenic expression of PdgfraΔK-EGFP (cyan) in nkx3.1:Gal4; UAS:NTR-mCherry (magenta) background at 56 hpf. mCherry+ EGFP+ cells are mostly restricted in the dorsal or ventral regions of the trunk. A transverse view of a 50 μm region centered on the dashed line is shown on the right, with the neural tube (nt) and notochord (n) outlined by dotted lines. Bottom: Model for how the migration of sclerotome-derived cells is regulated by chemoattraction mediated by Pdgfab/Pdgfra signaling. (A) In wild-type embryos, nkx3.1+ (cyan) sclerotome-derived cells express the receptor Pdgfra (magenta), while the medial somites express the ligand Pdgfab (orange) in response to Hh signaling. pdgfra+ sclerotome-derived cells undergo extensive migration toward both the notochord in the medial trunk and the fin fold. (B) In pdgfra−/− mutants (pdgframRFP/mRFP and pdgfraref/ref), nkx3.1+ sclerotome-derived cells fail to migrate in any direction and remain in their original location in the ventral and dorsal parts of the somites. (C) In pdgfab−/− embryos, pdgfra+ sclerotome-derived cells fail to migrate toward the notochord, although migration toward the fin fold remains unaffected. (D) In pdgfab−/− embryos with mosaic pdgfab expression, nkx3.1+ sclerotome cells can migrate toward the ectopic pdgfab-expressing cells, either medially around the notochord or ventrally toward the yolk extension. When the pdgfab source is located near or in the notochord, it can completely rescue the migration of nkx3.1+ sclerotome cells toward the notochord. These diagrams depict a 2-somite region located above the yolk extension of a zebrafish embryo at 48 hpf. nt: neural tube; n: notochord.

What guides fibroblast precursors' migration from the #sclerotome during vertebrate development? @penghuang031.bsky.social &co show that this is driven by #PDGF -mediated chemoattraction, enabling their differentiation into specialized #fibroblast subtypes @plosbiology.org 🧪 plos.io/3HTZ92Y

Top: Transgenic expression of PdgfraΔK-EGFP (cyan) in nkx3.1:Gal4; UAS:NTR-mCherry (magenta) background at 56 hpf. mCherry+ EGFP+ cells are mostly restricted in the dorsal or ventral regions of the trunk. A transverse view of a 50 μm region centered on the dashed line is shown on the right, with the neural tube (nt) and notochord (n) outlined by dotted lines. Bottom: Model for how the migration of sclerotome-derived cells is regulated by chemoattraction mediated by Pdgfab/Pdgfra signaling. (A) In wild-type embryos, nkx3.1+ (cyan) sclerotome-derived cells express the receptor Pdgfra (magenta), while the medial somites express the ligand Pdgfab (orange) in response to Hh signaling. pdgfra+ sclerotome-derived cells undergo extensive migration toward both the notochord in the medial trunk and the fin fold. (B) In pdgfra−/− mutants (pdgframRFP/mRFP and pdgfraref/ref), nkx3.1+ sclerotome-derived cells fail to migrate in any direction and remain in their original location in the ventral and dorsal parts of the somites. (C) In pdgfab−/− embryos, pdgfra+ sclerotome-derived cells fail to migrate toward the notochord, although migration toward the fin fold remains unaffected. (D) In pdgfab−/− embryos with mosaic pdgfab expression, nkx3.1+ sclerotome cells can migrate toward the ectopic pdgfab-expressing cells, either medially around the notochord or ventrally toward the yolk extension. When the pdgfab source is located near or in the notochord, it can completely rescue the migration of nkx3.1+ sclerotome cells toward the notochord. These diagrams depict a 2-somite region located above the yolk extension of a zebrafish embryo at 48 hpf. nt: neural tube; n: notochord.

What guides fibroblast precursors' migration from the #sclerotome during vertebrate development? @penghuang031.bsky.social &co show that this is driven by #PDGF -mediated chemoattraction, enabling their differentiation into specialized #fibroblast subtypes @plosbiology.org 🧪 plos.io/3HTZ92Y

Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...

Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!

www.biorxiv.org/content/10.1...

@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal

A #fibroblast population that could help us improve #skingraft survival www.jidinnovations.org/article/S266... #medderm #dermsky

The Buechler and Kapoor labs are teaming up to find a talented postdoc to work jointly between our labs at UofT/UHN. If you want to make a dent in the universe, please DM. #Immunology #fibroblast

www.buechlerlab.com and www.kapoorlab.ca

CALL FOR PAPERS

Special issue on the regulation of #fibroblast function in #physiology and disease 📖

Guest edited by Dr. Mario Manresa of ucddublin.bsky.social

Deadline⏰: 1st May 2026
🔗 physoc.onlinelibrary.wiley.com/hub/journal/...

🧠 #Fibrosis just published 3 new papers in our #Systemic_Sclerosis (SSc) special issue!

Explore the roles of:
🔬 NLRP3 #inflammasome & IL-11 in lung #fibroblasts
🧵 TANGO1 in collagen export
🧫 #Fibroblast migration & cytoskeleton remodeling

📖 Read: www.sciepublish.com/journals/fib...

🌤️June Journeys: Image of the Month 📅

Senescent human #fibroblast to study #aging🧓. Stained for F-actin (gold), nucleus (blue), lysosomes (magenta). Acquired on @zeiss-microscopy.bsky.social LSM 780🔬.

🎨 Artwork by Kamila Kozik, Membranology Unit @oistedu.bsky.social, Japan

#sciart #bioart

Morioka et al report Fetal #Fibroblast Heterogeneity Defines Dermal Architecture during Human Embryonic #SkinDevelopment
doi.org/10.1016/j.ji...
and the linked commentary
The Beauty of #Fibroblasts Is Several Skin Layers Deep and Much Deeper (R. Wilder Scott)
doi.org/10.1016/j.ji...
#dermsky

⚡ FIBROBLAST LIFTING SIN CIRUGÍA COMO NEGOCIO 💼 Eleva tu rentabilidad sin bisturí.

Accede aquí:🔗 https://f.mtr.cool/mvkpvoqblh

#Fibroblast #LiftingFacial #Estética #NegocioRentable #AntiEdad

Descobreixen una de les causes que fa el càncer de pàncrees tan agressiu Un estudi ha determinat noves funcions d'una proteïna ja vinculada amb aquests tumors que afavoririen la seva potència i la seva resistència als tractaments

👉 'Descobreixen una de les causes que fa el càncer de pàncrees tan agressiu'

#càncerdepàncrees #proteïna #fibroblast

@researchmar.bsky.social @csic.es

www.3cat.cat/324/descobre...