Local gene editing of #fibroblasts in tumors reveals a new cancer-associated fibroblast state. New study from Nicholas F. Kuhn, Matthew F. Krummel @maxkrummel.bsky.social @immunox.bsky.social and colleagues:
rupress.org/jem/article/...

#TumorImmunology #SolidTumors #TME #CAFs

We were made by AI, but the #cells formed the bridge naturally. 🤣 #biology #imaging #mechanobiology #cellmigration #fibroblasts

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…

#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!

https://thoracic.zoom.us/webinar/register/WN_KiZv45vNRe6bpnnXXJG9nQ

Are you a fan of #fibroblasts? Do you think about the lung ECM in your quiet moments? Then join David Boyd & a panel discussion as he presents “Integrated Longitudinal Transcriptomic & Proteomic Analysis of the Murine Lung Response to Influenza A Virus" t.co/2IdbWJVNDQ

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Intercellular communication from myotubes to fibroblasts is differentially impacted by mineralocorticoid receptor signaling and muscular dystrophy - Cell Communication and Signaling Cell Communication and Signaling - Replacement of striated muscle with fibrosis leads to the symptoms and fatality in Duchenne muscular dystrophy (DMD). Transient local production of the...

Happy to share our recent publication on intercellular communication from the Rafael-Fortney lab. Check this one out!
#fibroblasts #myotubes #DMD #skeletalmuscle #fibrosis

link.springer.com/article/10.1...

🔥Hot Off the Press | Facial Scarring Insights
#Fibroblasts “remember” their developmental origins, shaping wound healing.
✅Facial scars < back scars (neural-crest fibroblasts)
✅Higher #Robo2 & #Eid1 suppress scarring
✅Modulating #EP300 mimics scar-free healing
#WoundHealing

Primary bovine embryonic #fibroblasts demonstrate variable #fitness following #infection with avian influenza #H5N1 strains and are susceptible to a recently circulating human #H1N1pdm09 strain

Primary bovine embryonic #fibroblasts demonstrate variable #fitness following #infection with avian influenza #H5N1 strains and are susceptible to a recently circulating human #H1N1pdm09 strain, etidiohnew.blogspot.com/2026/02/prim...

ACTN4 p.Ile150Met Causes #FSGS With Validation in #Primary #Fibroblasts and Immortalized Podocytes

https://doi.org/10.1016/j.ekir.2025.11.030

#KIRResearchLetter

Single-Cell Omics Analysis Reveals Critical Cell Subtypes and their Functional Attributes in Myocardial Ischemia-Reperfusion Injury Announcing a new article publication for BIO Integration journal. Cardiac cell death and myocardial fibrosis after ischemia-reperfusion (I/R) injury are the primary causes of impaired cardiac function...

This study uses #SingleCellTranscriptomics to identify C0 Atcayos+ cardiomyocytes that interact with #fibroblasts via Bmp6 and Fgf1 signaling after #IschemiaReperfusion, uncovering pathways that could reduce #fibrosis and help preserve #cardiac function.

Read: bio-integration.org/single-cell-...

The face scars less than the body – a new study unravels why A Stanford Medicine study in mice shows that facial wounds scar less thanks to unique cellular pathways, opening the door to improved healing after surgery or trauma.

“we identified specific #healing pathways in #scar -forming #cells called #fibroblasts that originate from the neural crest [ype of cell in the early embryo] & found that they drive a more regenerative type of #healing.”: buff.ly/CIbKCJA

via @stanford.edu
#MedicalResearch #HumanBody #scarring

🔔 Issue 2 of 2026 is live! 🎉 Featuring:

🧑‍🔬 Scientists' Forum: Mothers in academia
🖊️ Review: #Fibroblasts in cancer metabolism
☀️ Review: Red-light #photosynthesis in eukaryotes
🦠 Research on #cancer biology and #microbiology

▶️ bit.ly/4ae2pRX

Interested in utilizing novel genetic tools to unpack the #immunology of #fibroblasts in #regenmed, #cancer, #metabolism, #osteoarthritis or #fibrosis and hope to make a dent in the universe? We are looking for #postdocs and #Canada is offering amazing opportunities for funding. www.buechlerlab.com

In a new @jem.org study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...

In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/...

#InfectiousDisease

John Hellicar, Dominic Lenz, Martin Lowe & co used #fibroblasts from individuals with #CALFAN syndrome, which affects the nervous system and liver, and revealed an accumulation of the secretory cargo procollagen type I in the #EndoplasmicReticulum

#RareDisease

Read doi.org/10.1242/dmm....

Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells - Molecular Biomedicine Benign prostatic hyperplasia (BPH) is a prevalent condition characterized by nonmalignant proliferation of epithelial and stromal components in the prostate, frequently resulting in lower urinary trac...

#Research
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells doi.org/10.1186/s435...

#BenignProstaticHyperplasia #Fibroblasts #Sunitinib #RTK #Signaling #CSF1R

Check out latest work from the LuxuriousLajoieLab✨🪿
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!

💸 Save $250 on Keystone Symposium on Fibrosis! Register by Dec 3, 11:59pm MST & get FREE access to the joint Stromal Immunology meeting.
Hear from co-organizer Marco Prunotto: youtu.be/rw1sSIYBcJQ

🔗 Register: keysym.us/KSFibrosis26

@ibd-flomd.bsky.social
#KSFibrosis26 #Fibrosis #Fibroblasts #COPD

Bronchial Fibroblasts Respond to House Dust Mite Challenge With Cytokine Secretion: Role in Allergic Airway Inflammation Schematic of the early-stage characteristics of house dust mites-induced bronchial fibroblasts, which are characterized by suppressed extracellular matrix production alongside activated inflammatory ...

🫁🔥 HDM-activated #bronchial #fibroblasts emerge as key drivers of airway #inflammation in allergic #asthma!
⚙️ Bronchial fibroblasts are not only structural cells but also direct responders to #allergens.
onlinelibrary.wiley.com/doi/10.1002/...

Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function...

New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social

Don't miss this episode!

Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.

Check it out: https://bit.ly/48dmghX

Tea Polyphenols Reduce Inflammation of Orbital Fibroblasts in Graves’ Ophthalmopathy via the NF-κB/NLRP3 Pathway

The study identifies #TeaPolyphenols as inhibitors of #Cytokine-driven #Inflammation in GO orbital #Fibroblasts through #NFκB/NLRP3 pathway, offering potential therapeutic insight. #medsky

#OpenAccess: link.springer.com/article/10.1...

PDGFRα is required for postnatal cerebral perivascular fibroblast development Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…

PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development

🚨New data🚨
In our latest preprint, Lea Mikkola et al. used single-cell & spatial omics, revealing how obesity can turn adipose tissue fibroblasts into immunologically active players in an atherosclerosis mouse model.
www.biorxiv.org/cgi/content/...
#Atherosclerosis  #Fibroblasts #Obesity #SingleCell

(C) Cartoon showing experimental approach for classifying UVR signature in GTEx patient cohort. (D) Tregs score from the peripheral blood of non-UVR (n=143) and UVR (n=142) GTEx patients, Mann-Whitney one-tailed test. GTEx, Genotype-Tissue Expression; MHC, major histocompatibility complex; NES, normalized enrichment score; PD-1, programmed cell death protein-1; RNA-seq, RNA sequencing; Treg, regulatory T cells; UVR, ultraviolet radiation.

In preliminary human data, there is an association between the molecular evidence of repeated ultraviolet radation (UVR) exposure in #dermal #fibroblasts and higher systemic #Tregs

See all the data online at:
jitc.bmj.com/content/13/1...

Diagram showing how sand fly saliva changes fibroblast state to promote arbovirus infection.

New paper out in iScience @cellpress.bsky.social
We show that #sand_fly biting reprograms skin fibroblasts, making them more permissive to virus infection
=> #fibroblasts aren’t bystanders, they help define severity/clinical outcome to infection AND #vector biting is key
👉 doi.org/10.1016/j.is...

Fibroblasts: Hidden drivers of heart failure progression – BioNews Central Scientists uncover how fibroblasts, once thought harmless support cells, send damaging signals that weaken the heart and drive heart failure. ...

Scientists uncover how #fibroblasts, once thought harmless support cells, send damaging signals that weaken the #heart and drive #HeartFailure. 

#Fibroblasts promote osmotic surveillance by wound-induced unique calcium patterns. New study from László Fazekas, Diána Kaszás, Boldizsár Vámosi, Balázs Enyedi @enyedilab.bsky.social et al. (Semmelweis University): rupress.org/jcb/article/...

#Physiology #Biochemistry #CellSignaling #Zebrafish

Congratulations to everyone involved, especially the two joint first authors, Nora and Thomas! Thanks also to the four reviewers for their helpful comments, which improved the manuscript.

#SCI, #Brillouin, #regeneration, #zebrafish, #AFM, #fibroblasts, #neutrophils