Lipid metabolism and redox balance are linked in type 2 immunity! We found that allergen-induced #ILC2s and #Th2 cells require cysteine-driven glutathione
synthesis to prevent #ferroptosis and
support #lipid metabolism and expansion of type 2 immune cells in #asthma.
Check out latest work from the LuxuriousLajoieLab✨🪿
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!
Cell therapy with IL-10-producing #ILC2s inhibited T cell accumulation within the graft and suppressed inflammatory T cell cytotoxic and inflammatory activity
In a surprise, we find the allogeneic human IL-10-producing #ILC2s are better able to inhibit antigen specific T cell rejection than autologous ILC2s, and that co-transplantation of #ILC2s with human islets enhanced glucose control post-transplant.
🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy
Excited to see our lab's first paper in @cp-immunity.bsky.social! It's amazing to see the intricate interplay between the enteric neurons and innate lymphocytes! Congrats to everyone involved!
#Immunology #Neuroimmune #ILC2s
#Immunity | #Parasites | @cp-immunity.bsky.social | #ILC2s & Enteric #Neurons worm their way into Host Defences in breaking study |
www.cell.com/immunity/abs...
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
This Perspective puts findings about androgens, ILC2s and dendritic cells in the skin into the broader context of differences in immunity between sexes.
https://buff.ly/41gMQoI
#Immunology #ILC2s #DendriticCells @science.org
From April '24: Differences in the density of immune cells in the skin of male and female mice was linked to male sex hormones called androgens acting on ILC2s.
https://buff.ly/49mbLZZ
#Immunology #ILC2s #Immunology #ILC2s #DendriticCells @science.org
