#glaucoma #cataract #agerelatedmaculardegeration #AMD #retinalvasculardiseases #lipid #lipiddisorders
www.archivesofmedicalscience.com/Understandin...
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From Michel Aliani @DREAM_diabetes A lipidomics approach identifies the #lipid classes modulated in response to fatty liver in #obesity fa/fa rats relative to lean Zucker rats changes in cardiolipin and PE suggesting altered mitochondrial structure www.plefa.com/article/S095...
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🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: A brain-specific microRNA, miR-1000, regulates lipid homeostasis via neuropeptide-like precursor 1 in Drosophila melanogaster
By Verma et al. and David Van Vactor
➡️ https://ow.ly/sCFM50YyTsG
Harvard Medical School
#Drosophila #lipid #metabolism #lifespan #miRNA
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#Tetraspanin CD82 shapes #EGFR signaling outcomes through nanoscale receptor organization. New study from Sebastian Restrepo Cruz, Jennifer M. Gillette and colleagues @unm.edu: rupress.org/jcb/article/...
#Cancer #Biophysics #Membrane #Lipid #CellSignaling
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Mechanoresilience of #lysosomes conferred by TMEM63A. New study from Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, and Spencer A. Freeman @sickkidsto.bsky.social: rupress.org/jcb/article/...
#Membrane #lipid #Organelles #Immunology #Metabolism
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Unbalanced #lipid metabolism in anther, especially the disorder of the alpha-linolenic acid metabolism pathway, leads to #cotton male #sterility
☀️🌈https://doi.org/10.1016/j.jia.2024.07.036
🔖Prof. Jie Sun team at Shihezi University
#PlantScience #Agronomy #Agriculture
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Reversible one-way #lipid transfer at ER–autophagosome #membrane contact sites via Atg2. New study from Li Hao, Kuninori Suzuki and colleagues @utokyoofficial.bsky.social: rupress.org/jcb/article/...
#Microbiology #Organelles
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☕New Review discusses #brain #lipid #metabolism from a cellular perspective, focusing on lipid uptake, de novo synthesis, storage, breakdown and intercellular transfer, and highlights its emerging implications for brain health and disease.
👉Read here: rdcu.be/e8rlJ
bit.ly/4rxWpJm
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Distinct TRAPP complexes activate Ypt/Rab #GTPases in #secretion and #autophagy. New study from Valeriya Gyurkovska, Nava Segev and colleagues (University of Illinois at Chicago): rupress.org/jcb/article/...
#Biochemistry #Membrane #lipid
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Kim, Freeman et al. @sickkidsto.bsky.social describe a mechanism for #lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants. rupress.org/jcb/article/...
#Lipid #Organelles #Immunology #Metabolism
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In @jcb.org, Kim, Freeman et al. @sickkidsto.bsky.social describe a mechanism for #lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants. rupress.org/jcb/article/...
#Lipid #Immunology
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New in Comprehensive Physiology🚨 Mini review by Ganamurali N et al.: Molecular Mechanisms of Lipid-Modifying Enzymes in #CellularAdaptation and Systemic #GlucoseHomeostasis. Read more here: https://ow.ly/LEjG50YruYv #lipid
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Hao, Suzuki et al. @utokyoofficial.bsky.social report that lipophilic dye octadecyl rhodamine B (R18) is transported to the ER mediated by #membrane transfer proteins. During #autophagy, ER-resident R18 is transferred to the autophagic membrane via Atg2. rupress.org/jcb/article/...
#lipid
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In a phase 1 trial with 6 patients, #lipid nanoparticles for #PCSK9 base editing lowered #LDL without serious adverse events or off-target effects. https://www.nature.com/articles/s41591-026-04254-4
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🚀Structural insights: #STING activation
GNE-6468 and Golgi #lipid #PI4P bind STING’s transmembrane domain, induce helix rearrangement, drive oligomerization, and trigger antiviral & antitumor #immunity.
MedChemExpress supported this study with high-quality #compound libraries.
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Hoi1 targets BLTP2 to ER–PM contact sites to regulate #lipid homeostasis. New study from Samantha K. Dziurdzik, Vaishnavi Sridhar, Elizabeth Conibear @lizconibear.bsky.social and colleagues (University of British Columbia): rupress.org/jcb/article/...
#Genetics #MembraneContactSites #ER_literature
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In @jcb.org, Dziurdzik, Sridhar, Conibear et al. identify a conserved adaptor that recruits BLTP2-like proteins to ER–plasma membrane contacts by binding helical projections on their lipid transfer channel to maintain #lipid homeostasis. rupress.org/jcb/article/...
#MembraneContactSites
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Dziurdzik, Sridhar, Conibear et al. identify a conserved adaptor that recruits BLTP2-like proteins to ER–plasma membrane contacts by binding helical projections on their lipid transfer channel to maintain #lipid homeostasis. rupress.org/jcb/article/...
#MembraneContactSites #ER_literature
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This week #JournalClub from @LabSoap @cp-immunity.bsky.social #lipid #neutrophils #TNBC #breastcancer #resistance www.cell.com/immunity/abs...
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☕Jacquemyn et al. identify key #lipid determinants controlling ectosome shedding from #neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to #Parkinsons disease pathology.
👉https://rdcu.be/e5k6a
bit.ly/46QhSpi
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“Because Lp(a) is #genetic, people can have high levels even with normal #LDL ..A screening must be ordered separately from the typical #lipid panel and is only required once in a lifetime.”: buff.ly/wDzuymF
from @yaleschoolofmed.bsky.social
#HeartHealth #HighCholesterol #cholesterol #MedSky
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On the #cover of #ACS Applied Materials & Interfaces (@ACS_AMI) an open access article about #Synergy between #Antimicrobial #Peptides and #Lipid #Nanoparticles for #Skin #Infection #Control
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Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/...
#ExM #Microscopy #StructuralBiology
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#Lipid alterations in hereditary #peripheralneuropathies: common mechanisms in disease heterogeneity?
Koen Kuipers, Sam Vanherle, Kirsten Poelmans, Esther Wolfs, Jeroen Bogie & Tim Vangansewinkel #neurodegeneration #schwanncells #demyelination
link.springer.com/article/10.1...
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Don't miss out on our webinars! Hit that subscribe button on our YouTube channel and get instant access to the recordings as soon as they're available. Stay updated and informed! 📺 www.youtube.com/@lipid-maps #Lipid #Lipidomics
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We hope this will be useful to anyone looking to identify ligands (substrates and inhibitors) of #lipid transporters. Thanks to @jeremybaskin.bsky.social for the invitation to write this! #lipidtime (2/2)
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In @jcb.org, Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #lipid #ER_literature #LipidDroplets
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Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets
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We have two IL-36 papers out, led by very talented #WomenInSTEM
Emma Welsh showed that IL-36 downregulates RNAse expression, promoting self-nucleic acid accumulation in #SLE shorturl.at/zFSAQ
Jillian Sieh described how IL-36 affects #macrophage #lipid uptake shorturl.at/uF1tB
#immunosky
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Yinyin Zhuang, @xyshi.bsky.social et al. introduce land-ExM, a superresolution approach that simultaneously maps protein and #lipid ultrastructure to reveal 3D interactions of #membrane #organelles and condensates. rupress.org/jcb/article/...
#ExM #Microscopy #StructuralBiology
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