CXCR5+CD8+ T cells in chronic #HBV exhibit effector and B-cell helper functions with preserved #cytokine production despite PD-1 expression, inversely correlating with viral load and highlighting their potential in enhancing #AntiviralImmunity.

#OpenAccess: doi.org/10.1016/j.ge...

Fundamental & Clinical Pharmacology: Vol 40, No 2 Click on the title to browse this issue

March issue now available!
#fundamental #clinical #pharmacology #statin #pharmacovigilance #addictovigilance #cannabis #ambroxol #dupilumab #buscopan #inflammation #cytokine #SGLT2i #heart #drug #repositioning #antinociceptive #SFPT @wileyhealth.bsky.social
onlinelibrary.wiley.com/toc/14728206...

We are pleased to announce that the following cytokines are now available as of March 16, 2026 — all with a 24‑hour TAT.

24‑Hour customized #Cytokine Results. 🏁

🏎️ Precision Built for Speed.

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Compartmentalized #cytokine #networks and systemic immune remodeling in #bovine mammary #H5N1 #infection.

Compartmentalized #cytokine #networks and systemic immune remodeling in #bovine mammary #H5N1 #infection, etidiohnew.blogspot.com/2026/03/comp...

Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression - Cell Death Discovery Cell Death Discovery - Osteocytic Lipocalin-2 regulates bone formation locally through iron-dependent ferroptosis and Wnt suppression

How does the #cytokine #Lipocalin-2 (#LCN2) link #bone and #EnergyHomeostasis? With help from Sable Promethion #Metabolic Cages, scientists revealed how LCN2 modulates bone remodeling by driving #ferroptosis & suppressing #Wnt signaling.

buff.ly/uMp5AmZ

#SLC22A17 #IndirectCalorimetry #Respirometry

IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. New study from Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/...

#InnateImmunity #inflammation

Immunomodulatory Effects of Hyoscine Butylbromide on Mammalian Macrophages Hyoscine butylbromide (HB), popularly known as Buscopan, is a common anticholinergic antispasmodic used worldwide for gastrointestinal disorders. While the interaction between the cholinergic system ...

Now available:
Immunomodulatory Effects of Hyoscine Butylbromide on Mammalian Macrophages
#fundamental #clinical #pharmacology #buscopan #cytokine #macrophage #antispasmodic #immune #inflammatory @wileyhealth.bsky.social @sfpt-fr.org
onlinelibrary.wiley.com/doi/10.1111/...

Gorin, Hoffmann et al. @ucla.edu report that IFNγ-induced enhancers and potentiated stimulus-response capabilities in #macrophages are maintained by persistent JAK/STAT signaling from #cytokine sequestered at the cell surface. rupress.org/jem/article/...

In @jem.org, Gorin, Hoffmann et al. @ucla.edu report that IFNγ-induced enhancers and potentiated stimulus-response capabilities in #macrophages are maintained by persistent JAK/STAT signaling from #cytokine sequestered at the cell surface. rupress.org/jem/article/...

Miniature noses to help prevent infections and promote nasal health Miniature noses offer a new way to study how the nasal microbial community affects diseases like chronic sinusitis or respiratory infections.

3️⃣ bacteria—S. aureus, S. pneumoniae, & D. pigrum—were introduced to human nasal organoids. All colonized w/o major damage, but the first two raised #cytokine levels. D. pigrum lowered cytokines, hinting at protective effects.

Read more in @bcmfromthelabs.bsky.social:
blogs.bcm.edu/2025/10/16/f...

#Stress hormones and sympathetic activation raise blood glucose. Additionally, a positive feedback loop links proinflammatory #cytokine​s to glycaemia. In critical illness, the stress hyperglycaemia ratio helps to distinguish the effects of acute stress from underlying #hyperglycaemia.

🧪 🩺 #MedSky

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...

Long #COVID (n=142)→ persistent activation of chronic #inflammation. Including proinflammatory #cytokine signaling, #complement activation, #metabolic dysregulation and immune #exhaustion. Suggestion of link between metabolic dysregulation and inflammation. go.nature.com/48UfU7B
[open access].

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

Single-cell transcriptomics of the Epo/IL-17A synergism in erythropoiesis. Left: UMAP visualization of single-cell transcriptomes across conditions and tissues, colored by annotated cell states. MPP, multipotent progenitor; EBMP, erythroid-basophilic-megakaryocytic progenitor; BaMaP, basophil-mast cell progenitor; MegP, megakaryocyte progenitor; EosP, eosinophil progenitor; LyP, lymphoid progenitor; GMP, granulocyte monocyte progenitor; MoP, monocyte progenitor; imMo; immature monocyte; mMo, mature monocyte; NeuP, neutrophil progenitor; imNeu, immature neutrophil; mNeu, mature neutrophil; imB, immature B cell; proB, proB cell; T, T cell; cDC1/2, conventional dendritic cell 1/2; pDC, plasmacytoid dendritic cell; Mac, macrophage; EEP, early erythroid progenitor (BFU-e equivalent); CEP, committed erythroid progenitor (CFU-e equivalent); ProE, proerythroblast; BasoE, basophilic erythroblast; PolyE, polychromatic erythroblast; OrthoE, orthochromatic erythroblast; pyrenocytes, and reticulocytes. Right: Relative cell densities across the sampled RNA-Seq state space, evaluated in high dimensions and visualized on the UMAP plot. The plots are colored by the log2-transformed ratio of cell densities in the neighborhood of each sampled transcriptome, for each treatment pair as indicated.

#Erythropoietin can be an effective #anemia treatment, but not with cancer or chronic disease. This study identifies the pleiotropic #cytokine IL-17A as a stimulator of #erythropoiesis in vivo that acts by amplifying the response of erythroid progenitors to Epo @plosbiology.org 🧪 plos.io/3KDskbX

“What if one #Cytokine could predict who benefits from #Ocrelizumab? 🤔🔥”
High #TNF mRNA at baseline = higher #MS activity after 24 months!📈 @mdpiopenaccess.bsky.social
#MultipleSclerosis #Neuroimmunology #Biomarkers
Read more & share 👉
www.mdpi.com/1422-0067/26...

A first-ever evaluation of the BM microenvironment in AIHA, reveals a complex scenario marked by T-cell infiltration, clonality, and varied #cytokine gene expression, associated with clinical severity, response to therapy, and outcomes.

#STTT #OpenAccess: doi.org/10.1038/s413...

#Treg-derived IFNγ and #IL10 synergistically activate #mTORC1 and Myc pathways to promote epithelial repair, with combined #cytokine signaling supporting #IntestinalStemCell growth after therapy-induced #GutInjury. @tum.de @univparissaclay.bsky.social

#STTT: doi.org/10.1038/s413...

“What if one #Cytokine could predict who benefits from #Ocrelizumab? 🤔🔥”
High #TNF mRNA at baseline = higher #MS activity after 24 months!📈 @mdpiopenaccess.bsky.social
#MultipleSclerosis #Neuroimmunology #Biomarkers
Read more & share 👉
www.mdpi.com/1422-0067/26...

This study identifies an osteoarthritic (OA) cartilage-specific ProFC subset (ProFC-2) marked by enhanced #Cytokine signaling and #Inflammatory activity, highlighting it as a potential contributor to OA progression. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

🎁 Claim your free cytokine sample today!

@sinobiological.com is offering high-purity, bioactive cytokines for research in #immunology, regenerative #medicine, and #celltherapy.

🔬 Complete the form to request the #cytokine you’d like to try 👉

www.bioscience.co.uk/sino-biologi...

Check out:

Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19

doi.org/10.1016/j.im...

Serum IL-32, IL-8, and IL-10 levels are associated to lung sequelae after COVID-19.

#COVID-19 #cytokine #immunology #immunobiology

Cytokine concentrations in people with eating disorders: A comprehensive updated systematic review and meta-analysis - Communications Medicine Keeler et al. report an updated meta-analysis of peripheral cytokine concentrations in individuals with eating disorders. Results reveal elevations in interleukin (IL)-6 and IL-15 and reductions in IL-7 in people with anorexia nervosa in comparison to healthy controls, and no elevations in pro-inflammatory cytokines in people with bulimia nervosa.

🚨 NEW RESEARCH! ⚕️ 🩺

Keeler et al. report an updated systematic review and meta-analysis of peripheral #cytokine concentrations in individuals with eating disorders.

https://bit.ly/3WCT8vq

@jhnnklr @kingsedresearch
#EatingDisorders

📰New & Featured | New in Science Translational Medicine:
Blocking #IL-4Rα (#dupilumab) or #IL-33 (#itepekimab) modulates distinct yet overlapping pathways in asthma.
Dual blockade helps resolve severe mixed inflammation, guiding precision biologic therapy.
#Asthma #Immunology #Cytokine

Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!

Treat #irAEs associated with #Bispecifics and T cell Engagers! Access the latest updates on #cytokine release syndrome and #immune effector cell-associated neurotoxicity during our free #webinar Dec. 17. Learn more and register: https://ow.ly/GByq50XgXSH

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations This study aims to investigate how immune activation influences the epigenetic regulation and expression of the Interleukin-6 (IL-6) gene during asthma exacerbations. By examining molecular mechanism...

⚡ #Asthma: Researchers at @fzborstel.bsky.social identify IL-6 as a key factor in severe disease flare-ups following viral infections. This #cytokine could serve as a #biomarker and open up new therapeutic approaches.
▶️ onlinelibrary.wiley.com/doi/10.1111/...

This article reviews #SystemicLupusErythematosus research, categorizes three key mechanisms—immune attenuation, #cytokine balance restoration, and debris clearance rescue—and emphasizes the potential of precision medicine. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This review examines the pathogenic mechanisms and therapeutic advances in Sjögren’s syndrome, emphasizing immune dysregulation, cytokine imbalances, and future directions for diagnostics and treatment.
#HM #biomarkers #cytokine #immunopathogenesis #immunotherapy
www.sciltp.com/journals/hm/...