Why do studies claiming #Treg induction by novel designer drugs test them only when given before or with antigen, rather than in established disease that more closely reflects human cases?
#science
#immunology
#Foxp3
www.nature.com/articles/s41...
皮膚老化の新確認！免疫細胞が老化を促進するメカニズムを解明 #免疫細胞 #皮膚老化 #Treg
新たな研究により、免疫系の異常が皮膚の老化を引き起こすメカニズムが判明。TregやIL-17の役割を探り、老化防止の新たなアプローチを示唆します。
#pacificadores.-El hexapéptido DLST-6P (rojo anaranjado) involucrando una célula T #treg reguladora (en primer plano, azul). Potencia la función de las células Treg, como estrategia para promover la tolerancia inmune, alivian la colitis, periodontitis como aplicación terapéutica.
This study, co-authored by Dr. Song Guo Zheng, identifies a previously unrecognized role of CD8+ T cells in enhancing induced #Treg differentiation, stability, and suppressive function through the ROS/TGF-β–IRF4 pathway.
🔎 Discover more: https://bit.ly/4aLxZWc
#OpenAccess
Figure 1. SWEET pilot study design.
Can #sucralose enhance #Treg cells? The SWEET trial investigates! #transplant @facmed-umontreal.bsky.social l @csnscn.bsky.social @cjkhd.bsky.social
doi.org/10.1177/2054...
This study of natural food-specific #Treg development, two years in the making, reveals surprising results that challenge using artificial antigens like OVA. “BioRxiv v2, posted recently, likely signals journal acceptance.
#science
#immunology
#Foxp3
buff.ly/zcrV1Up
Tomorrow, in #preprinthub2 @alisaiakupova.bsky.social will present a preprint from Xuyu Zhou’s lab on how #TCR signal strength determines #Treg instability and discrimination of self versus non-self antigens 🐁 ⏳🌪️ #immunosky
www.biorxiv.org/content/10.6...
For all #Treg lovers, @labliston.bsky.social @annualreviews.bsky.social 👇👇👇 👉 doi.org/10.1146/annu...
🎆 In January 2026, the first #Treg-based therapy for T1D entered clinical trials. The Buckner lab at @benaroyaresearch.bsky.social is already looking forwards.
“My hope is that we can rapidly invest in making this drug [available] to everyone who needs it,” Dr. Buckner said: https://bit.ly/407vWqE
A @cityofhope.bsky.social team reported TDRD3 as a central transcriptional regulator of induced #Treg differentiation and immune homeostasis, highlighting it as a potential therapeutic target for modulating immune tolerance. 🎯
▶️ Get the full story: https://bit.ly/4k9CWN4
Recent Treg biotech trajectories show that current Treg-based tech do not work. Why? Unlike conventional T cells, Tregs operate within a tripartite system involving the microbiota and naturally IL-2–producing T cells.
#science
#immunology
#Treg
www.biospace.com/biospace-lay...
Screenshot of new paper published in the Cell Press journal Immunity, "The history and promise of Treg cells," by Christophe Benoist, Dario A.A. Vignali, Richard A. Flavell, and Diane Mathis.
New in @cp-immunity.bsky.social: @vignalilab.bsky.social and colleagues tell the #Treg story, tracing the history of these critical immune regulator cells and their path to earning the 2025 #NobelPrize. authors.elsevier.com/c/1mF0B3qNrU...
IFN-λs suppress autoreactive Th1 & Th17 cell responses, promote #Treg expansion, and regulate NLRP1/NLRP3 signaling to preserve BRB integrity and attenuate #OcularInflammation in experimental #Autoimmune #uveitis. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
免疫系による自身への攻撃を抑える免疫寛容において中心的な役割を果たす転写調節因子 今月の分子312: FOXP3 numon.pdbj.org/mom/312?l=ja #PDB #制御性T細胞 #Treg
New data from Nektar Therapeutics shows REZPEG, an investigational eczema treatment, also improved asthma symptoms in patients with both conditions. A potential dual-benefit therapy.
#News #dermatitis #asthma #clinicaltrial #biologic #Treg #AtopicDermatitis
New data from Nektar Therapeutics shows REZPEG, an investigational eczema treatment, also improved asthma symptoms in patients with both conditions. A potential dual-benefit therapy.
#News #dermatitis #asthma #clinicaltrial #biologic #Treg #AtopicDermatitis
Researchers engineered HLA-A2-specific CAR regulatory T cells (A2-CAR Tregs) that controlled both transplant rejection and autoimmune attack in islet-transplanted mice. A promising step toward long-lasting tolerance. 👉 #Immunology #Treg
www.science.org/doi/10.1126/...
@bcchresearch.bsky.social
New work from the lab of Dr. Wan-Lin Lo at @utah.edu demonstrates that age-dependent Zap70 expression regulates negative selection and thymic #Treg cell development.
Study🗒️: https://go.nature.com/4o9oqWn
Episode 🔊: https://bit.ly/3LlRCeo
www.nature.com/articles/s41...
“we observed an expansion of dysfunctional #Treg in pts with #lupusnephritis, along with↑ of TLR5 and FCRL3 in naive Treg… These findings highlight distinct CD4⁺ T cell subsets that may contribute to aberrant antibody responses and impaired immune regulation in #SLE.”
This study shows that Bcl6 maintains #Treg cell stability and suppressive function in #HNSCC, and suggests that targeting Bcl6 could disrupt Treg-driven #Immunosuppression, highlighting a promising #therapeutic strategy for treating HNSCC. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#TechnologyTuesday
𝗡𝗼𝘃𝗲𝗹 𝗖𝗔𝗥𝘀 𝗳𝗼𝗿 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗼𝗳 𝗠𝘂𝗹𝘁𝗶𝗽𝗹𝗲 𝗦𝗰𝗹𝗲𝗿𝗼𝘀𝗶𝘀 𝗮𝗻𝗱
𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿´𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
🔬 Medizinische Hochschule Hannover
🔎 Learn more about this #technology on our website: www.ascenion.de/technologiea...
#ChimericAntigenReceptor #Treg #Immunotherapy #CellTherapy
We are excited to welcome Julian Arian to our AG Sparwasser at the IMMH! Julian is conducting his project work on metabolic signaling regulation during the differentiation of regulatory T cells under the supervision of Luana, one of our PhD students.
#Immunology #TCells #Treg #ImmuneModulation
Context-dependent requirements for Foxp3 in #Treg functions. Foxp3 is required for function of newly generated Tregs, but Foxp3 loss in mature Treg cells resulted in minimal functional changes under steady state. However, tumoral Tregs are uniquely sensitive to loss of Foxp3.
rdcu.be/eKK4r
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!
bit.ly/SciImm_free
It's a big week for regulatory T cells! ⭐ #Treg
Refresh your understanding with our wallchart on the development, phenotype, and functions of Tregs: https://bit.ly/48gyyb7
The #Nobel prize has been assigned to the discovery of #Treg peripheral tolerance. We are humbly greatful for this discovery as we recently described a subtype of Tregs associated with worse breast cancer prognosis
Low: #Nobel Prizes in #science go to 8 men 1 woman (again)
High: @clarivate.com predictions were wrong, breaking the #Matthew effect: giving prizes to those that already won prestigious prizes, are #highlycited, are in topX% rankings... AND seminal #Treg paper was published in @jimmunol.bsky.social
www.nature.com/articles/d41...
“Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’ 🎊”
“Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.”
#autoimmune #Tcell #Treg #immunology
🏅Nobelpreis für Shimon #Sakaguchi, Mary E. #Brunkow und Fred #Ramsdell für die Entdeckung der peripheren #Immuntoleranz.
Sakaguchi entdeckte die regulatorischen T-Zellen #Treg, Brunkow und Ramsdell den dazugehörigen Transkriptionsfaktor #FoxP3.
Große Freude, weil jahrelang mein täglich Brot.
