Rayes et al. outline the clinical, genetic, & immunologic features of a novel #FOXP3 missense variant causing severe, treatment-resistant #IPEX in an infant, emphasizing the usefulness of quantifying TSDR-demethylated cells as an early biomarker of IPEX disease activity. rupress.org/jhi/article/...
Rayes et al. outline the clinical, genetic, & immunologic features of a novel #FOXP3 missense variant causing severe, treatment-resistant #IPEX in an infant, emphasizing the usefulness of quantifying TSDR-demethylated cells as an early biomarker of IPEX disease activity. rupress.org/jhi/article/...
In @jhumimmunity.org, Fréret, Escudier et al. describe a child with #IPEX due to a #FOXP3 mutation, presenting with carotid perivasculitis consistent with TIPIC syndrome on multimodal imaging, who achieved clinical and radiologic remission after corticosteroids. rupress.org/jhi/article/...
Fréret, Escudier et al. @hopitalnecker.bsky.social describe a child with #IPEX due to a #FOXP3 mutation, presenting with carotid perivasculitis consistent with TIPIC syndrome on multimodal imaging, who achieved clinical and radiologic remission after corticosteroids. rupress.org/jhi/article/...
Why do studies claiming #Treg induction by novel designer drugs test them only when given before or with antigen, rather than in established disease that more closely reflects human cases?
#science
#immunology
#Foxp3
www.nature.com/articles/s41...
The exclusive role of RORγt⁺ APCs in inducing or expanding Tregs in the periphery has been challenged. Back to square one.
#science
#immunology
#Foxp3
www.biorxiv.org/content/10.6...
This study of natural food-specific #Treg development, two years in the making, reveals surprising results that challenge using artificial antigens like OVA. “BioRxiv v2, posted recently, likely signals journal acceptance.
#science
#immunology
#Foxp3
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The identification of regulatory T cells and #Foxp3 has shaped modern #immunology and contributes to antibody-research approaches worldwide! Along with spurring the advancement in treatments for #cancer and #AutoimmuneDiseases.
Congrats to Drs. Mary Brunkow and Fred Ramsdell on receiving the #NobelPrize in Physiology or Medicine! 🏆
We discuss their early work identifying #FOXP3 as a master regulator of regulatory T cells.
🎧 https://bit.ly/3LlRCeo
Mary Brunkow’s #FOXP3 discovery earned her a Nobel, though she left the field soon afterward. Douglas Prasher cloned #GFP in 1992, left the field too, and was notably left out of the #Nobel for its discovery.
#Brunkow
#Prasher
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5/8
The discovery of #FOXP3 was the key that unlocked the puzzle.
They found that without the FOXP3 gene, regulatory T cells cannot form. This allows the #ImmuneSystem to go wild, attacking the body's own organs, a condition mirrored in a rare human disease called #IPEX.
4/8
But what controlled these crucial cells? That answer came from Drs. Brunkow and Ramsdell.
After years of arduous work at a biotech company, they studied mice with a severe #autoimmune disease and found the single missing gene responsible. They named it #FOXP3.
#Science #Genetics
Nobelpreise für Medizin 2025 geht an Shimon Sakaguchi, Mary Brunkow & Fred Ramsdell für ihre bahnbrechenden Arbeiten zur peripheren Immuntoleranz. Gratulation 👏
#Tregs #Tolerance #FoxP3 #Nobel2025
Super Erklärstück dazu von @florianschumann.bsky.social @jasimmank.bsky.social @zeitonline.bsky.social
🏅Nobelpreis für Shimon #Sakaguchi, Mary E. #Brunkow und Fred #Ramsdell für die Entdeckung der peripheren #Immuntoleranz.
Sakaguchi entdeckte die regulatorischen T-Zellen #Treg, Brunkow und Ramsdell den dazugehörigen Transkriptionsfaktor #FoxP3.
Große Freude, weil jahrelang mein täglich Brot.
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
Great recognition to a fundamental discovery that reshaped modern #immunology. Congrats to the laureates!
However, imho the Nobel committee missed the chance to acknowledge an additional key contributor to the understanding of #Foxp3 and #Treg functionality
3/6 Sakaguchi first hypothesized these “security guard” T cells existed in the 90s 🧐 Brunkow & Ramsdell later linked a gene (FOXP3) to a rare autoimmune disease (IPEX), confirming his work! 🧬🤝 #FOXP3 #GeneticResearch #IPEX
3/5 Sakaguchi first hypothesized these “security guard” T cells existed in the 90s 🧐 Brunkow & Ramsdell later linked a gene (FOXP3) to a rare autoimmune disease (IPEX), confirming his work! 🧬🤝 #FOXP3 #GeneticResearch #IPEX
13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.
#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs
Not just ‘memory T cells act as microbial surrogates to drive innate immune activation and inflammation’, activated CD4 T cells can as well. This is precisely why only antigen-specific Tregs can keep anti-self T cell responses from spiraling out.
#Foxp3
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5/ Tellingly, even Shevach himself later made a U-turn, now arguing suppression is antigen-specific.
#immunology
#tolerance
#Foxp3
#Tregs
Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !
#WeekendRead! #ToSuppressOrNotToSuppress! Van Der Veeken &co show @ Science Immunology that transient depletion of #Foxp3 doesn’t alter #Tregs under homeostasis but during inflammation continuous Foxp3 activity is necessary to actively suppress transcriptional programs!
Another study using auxin-inducible #Foxp3 degradation just after Rudensky lab’s preprint. Curious overlap. Parallel thinking or a race to publish? 🧬👀
#Tregs
#immunology
#immunosky
#science
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ONLINE COVERLNP mRNA Vaccines Get a Boost. Lipid nanoparticle (LNP) mRNA vaccines induce robust immune responses and provide protection against infectious diseases, but this immunity can be short-lived, necessitating frequent booster vaccinations. Aunins et al. investigated how adjuvanting LNP-mRNA vaccines with mRNA encoding the cytokine interleukin-12 (IL-12) influences CD8 T cell responses in mice. Il12 mRNA-LNPs (LNP–IL-12) enhanced antigen-specific CD8 T cell responses and CD8 T cell memory, providing greater protection against bacterial infection and in a mouse model of melanoma. Cytokine-adjuvanted mRNA-LNPs may help future vaccine platforms better tailor the magnitude and nature of the immune response. This month’s cover image features a stylized mRNA-LNP with various lipid (red, coral, and pink) and cholesterol molecules (maroon) encapsulating Il12 mRNA (yellow). Credit: A. Mastin/Science Immunology
The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost!
New content every week! Check it out!
www.science.org/toc/sciimmun...
Recent research connects RORγt⁺ APCs to food-specific pTregs in tolerance. But a new study from the Sakaguchi lab reveals these pTregs are short-lived and unstable potentially challenging existing models of oral tolerance.
#immunology
#tolerance
#Foxp3
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There’s been a wave of new research lately on RORγt⁺ APCs, pTregs, food tolerance, and the microbiota. Here’s the newest paper.
#Tregs
#Foxp3
#food
#allergy
#microbiota
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2/💡 They engineered a system to reversibly degrade Foxp3, the master regulator of Treg identity. This lets them test what happens when #Foxp3 protein vanishes in adult mice. 🔄🧬
