13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.

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#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs

Why T Cell Tolerance Is Fixed from Birth

1. Unlike the innate immune system, which uses receptors to discriminate self from nonself based on biochemical features of the ligand (like LPS, foreign DNA, or foreign RNA)

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#tolerance
#selfnonself
#science
#theory
#Tregs

This RNA Twist Could Rewrite What We Know About “Self” and “Nonself” Scientists found that pseudouridine helps small RNAs pass on traits and avoid immune detection, offering clues for future RNA-based treatments and how the body tells “self” from “nonself.” Not...

This RNA Twist Could Rewrite What We Know About “Self” and “Nonself” #Science #Biology #MolecularBiology #RNA #SelfNonself

6/ Can tumors induce new Tregs with novel specificity? ❌ No.

Tregs don’t develop in the periphery by bypassing thymic selection. That would break self-nonself discrimination. Tumors cannot create genuine Tregs.

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#immunology
#selfnonself
#Foxp3
#Tregs

6/ Can tumors induce new Tregs with novel specificity? ❌ No.

Tregs don’t develop in the periphery by bypassing thymic selection. That would break self-nonself discrimination. Tumors cannot create genuine Tregs.

#tumor
#immunology
#selfnonself
#Foxp3
#Tregs