Investigators revealed a novel phagocytosis-mediated, paracrine mechanism of enzalutamide resistance orchestrated by androgen receptor-positive tumor-associated #macrophages. 💊
🔓 Read the full article: https://bit.ly/41FMjM6
We are actively recruiting a postdoctoral fellow to join our lab @jacksonlab! 😎 Details and link to apply: thejacksonlaboratory.wd503.myworkdayjobs.com/External_JAX...
Confocal microscopy image of retinal astrocytes
It's #FluorescenceFriday and these retinal astrocytes understood the assignment: branching, glowing, and casually laying down the blueprint for the retinal vasculature #Retina #ConfocalMicroscopy
🔬 Scientists provide a real-world analysis for PARP-inhibitor use in advanced breast cancer (ABC) patients treated within the prospective German PRAEGNANT registry.
152 patients with ABC receiving a PARP inhibitor were included.
🔗 https://go.nature.com/4dLpsGa
A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute at @keck.usc.edu has received a major grant from the #NIH to investigate a long-standing mystery in #Alzheimers disease.
📰 https://bit.ly/48ROb8f
Oxidoreductases are enzymes that catalyze oxidation–reduction reactions during carbon metabolism. 💭
This review outlines mechanisms by which oxidoreductases couple metabolic flux to epigenetic landscapes that maintain or dissolve #stemness.
📖 https://go.nature.com/3PZiUtJ
GIVEAWAY! 🤩🎉
Upgrade your lab style with a pair of @stemcell.com science socks.🧦
To enter, subscribe to any of the Science News newsletters and get the latest updates in your field delivered straight to your inbox.
📣 You have until June 30th: https://bit.ly/4sDul83
Dr. Ulrich Steidl at Montefiore Einstein Comprehensive Cancer Center has been awared the International Society for Experimental Hematology 2025 McCulloch & Till Award.
📰 https://bit.ly/4takPKl
MSCs can regulate IgA production and clearance by controlling B cells, T cells, and mucosal epithelial cells. 🧫
This review covers advances in IgA nephropathy using stem cell therapy, including disease mechanisms and treatment pathways.
📖 https://bit.ly/428FOkW
Scientists demonstrate that affinity combination represents a promising strategy to generate more effective CAR-T-cell products with an improved therapeutic index, beyond affinity engineering alone. 🔬
🆕 https://go.nature.com/4thbmRS | @natcomms.nature.com
🔬 In this study, researchers utilized a self-organizing skin #organoid system to investigate how epidermal and dermal cells adapt to a hypoxic environment.
Learn more:
https://go.nature.com/4tIRaYL
Scientists explored the molecular mechanism by which LRRC41 promotes HCC malignancy and investigated the therapeutic potential of inhibiting its mediated signaling pathway.
📝 https://go.nature.com/4tAAjau
Immune modulatory vaccines (IMVs) are an emerging class of #immunotherapy designed to expand anti-#Tregs that selectively target immunosuppressive elements within the TME. 💉
Learn more in Dr. Mads Hald Andersen's @sigtrans-sttt.bsky.social's paper:
📖: https://go.nature.com/4tZDxVp
🦴 Scientists review in vivo bone regeneration strategies for critically sized defects, summarizing how animal models are developed and how biomaterial, cellular, and drug delivery platforms are tailored to these disease states.
https://bit.ly/4caVHfk
Researchers develop a simple, scalable method to generate stable hindbrain-like neural stem cells from #hiPSCs using Wnt activation and dual SMAD inhibition, enabling long-term culture and disease modeling.
▶️ https://bit.ly/41icFn8
Dr. Susanna Brighenti and co-authors discuss the potential of immune endotypes to advance precision medicine in #tuberculosis, moving beyond one-size-fits-all treatment to improve outcomes, especially in drug-resistant cases. 💊
📖 Don't miss the review: https://bit.ly/3QqOsbO
For his work towards developing a novel cancer #immunotherapy that turns tumors into their own vaccines, Dr. Fábio Rosa has received the 2026 BioInnovation Institute & Science Prize for Innovation. 💉
Congratulations! 🤩
🗞️Learn more: https://bit.ly/4t8LvLu | @aaas.org
Researchers at @mdanderson.bsky.social investigated the impact of IL-1R1 blockade on the efficacy and toxicity of agonistic CD40 antibody therapy in PDAC.
🔗 https://go.nature.com/4ty6XcR
Researchers identify DOT1L, a histone methyltransferase, as a key #epigenetic regulator of endothelial-to-mesenchymal transition and fibrotic progression.
They highlight DOTL1 as a potential therapeutic target in fibrotic lung disease. 🫁
🎯 https://bit.ly/41irWUT
This article reveals that CD8+ T cells mediate vaccination-induced prevention of #tuberculosis (Mtb) dissemination in the absence of CD4+ T cells, informing latent Mtb infection management in #immunocompromised individuals. 💉
🔗 go.nature.com/4sdHfZV
The Prostate Cancer Foundation announced the launch of the Hästens-PCF Global Health Award. 🏅
The award will support the expansion of STAMPEDE2 – a clinical trial testing new therapies in patients with advanced #ProstateCancer in Nigeria.
https://bit.ly/4cnQnXa
🧪 Scientists identify lactate as a driver of NK cell suppression and highlight lactate transport and receptor targeting as a strategy to enhance NK cell–based immunotherapies in breast cancer and other lactate-rich tumors.
https://go.nature.com/41H0Mag
New opportunity in #InfectiousDisease research! 👇🦠
📢 New episode!
We chat with Dr. Aitor Aguirre (@aaguirre1980.bsky.social) from Michigan State University about how his lab uses pluripotent stem cells and #CardiacOrganoids to model human heart development and disease.
🎧 Listen now: https://bit.ly/4sKXLlt
Researchers identified ITGA3 as a key driver of circulating tumor cell generation and metastatic progression in #PDAC.
ITGA3 promotes EMT, enhances matrix metalloproteinase expression, and facilitates tumor cell detachment. 🧫
🔓 go.nature.com/4sM7BmT
A distinct #leukemia subtype with a surprising weakness!
Researchers from the University of Osaka uncover a distinct NUTM1-rearranged leukemia subtype with stem-like features and notable vulnerability to chemotherapy. @bloodjournals.hematology.org
📕 https://bit.ly/4dh4tL5
🥼 New research led by Drs. Yemin Wang and David Huntsman, uncovers a fibroblastic origin for DICER1-related tumor predisposition #sarcoma and provides a mouse model for future mechanistic and translational investigation. @natcomms.nature.com
📚 https://go.nature.com/4dmGvhC
A review that is not to be missed! 🤩
Happy to share this study from the lab led by Orlaith Keenan published in mBio!
Working with an outstanding collaborative team, Orlaith demonstrated that maintaining the right balance of neutrophils is key to limiting severe disease during C. difficile infection. journals.asm.org/doi/10.1128/...
The background is a microscopy image with cells and at the bottom you can see the four group leaders
Congratulations! Jeroen den Hertog, @bakkerslab.bsky.social , @fmattiroli.bsky.social and Eva van Rooij received ZonMw Open competition grants to study RASopathies and heart regeneration. Read more here: www.hubrecht.eu/zonmw-grants...
