#Treg-derived IFNγ and #IL10 synergistically activate #mTORC1 and Myc pathways to promote epithelial repair, with combined #cytokine signaling supporting #IntestinalStemCell growth after therapy-induced #GutInjury. @tum.de @univparissaclay.bsky.social

#STTT: doi.org/10.1038/s413...

A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut Multipotent adult stem cells balance self-renewal with differentiation into various cell types. How this balance is regulated at the transcriptional l…

I've been away from social media for some time, but I'm very happy to share that we just got a paper out describing how a network of bHLH transcription factors simultaneously regulates #Drosophila #IntestinalStemCell self-renewal and bipotential differentiation
www.sciencedirect.com/science/arti...

Epithelial Zonation of 👦🐭small intestine
scRNAseq

5 (instead of 3) zones▶️Nutrient metabolism

3 Lgr5+ #IntestinalStemCell populations▶️a Hoxb7/8/9+ subset

ChEA3+SCENIC▶️transcrptional control of intestinal domains

#NatureCellBio 2024
www.nature.com/articles/s41...