Transposable Elements LTR7 as mechano-responsive enhancer elements
Matrix stiffness (40 vs 1 kPa)▶️
YAP/TEAD1-BRD4-CTCF▶️
FAM-LTR7▶️
FAM189A2▶️
⏬definitive endoderm differentiation hESC
352 TE subfamilies changed by Stiffness🤠
@yaruidiao.bsky.social #NatureCellBio 2025
www.nature.com/articles/s41...
LIANA+ models cell-cell communication for Spatial Mulitomics with single-cell data
"Using spatially weighted cosine similarity", specific locations for metabolite ligand-receptor interactions are identified
9 LR methods
github.com/saezlab/lian...
#NatureCellBio 2024
www.nature.com/articles/s41...
#Heterochromatin #Celegans
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity
A must-read for heterochromatin learners👏
How much of this 🪱knowledge translatable to mammals?😆
Susan Gasser lab #NatureCellBio 2021
www.nature.com/articles/s41...
De novo Heterochromatin (H3K9me1/2/3) assembly (by G9a) stabilizes stalled/stressed replication fork (by Hydroxyurea)
Its timely disassembly by JMJD1A/KDM3A enables fork restart
Occurs at a time scale of minutes!😎
#NatureCellBio 2023
www.nature.com/articles/s41...
Landmark revisit
#Angiogenesis #CellCompetition VEGFR1/2 NOTCH
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
#NatureCellBio 2010
www.nature.com/articles/ncb...
Proliferation-driven Mechanical Compression in #EnamelKnot - Signaling organizer for incisor🦷morphogenesis
Measuring #MechanicalAnisotropy in vivo using 3D imaging of oil microdroplets
#YAP/TAZ (again), not #Piezo, as a mechanotransducer
#NatureCellBio 2024
www.nature.com/articles/s41...
#YAP #Lumenogenesis #EmbryonicCompetence 😎
Mechanosensitive #NeuralCrest induction in early #Embryogenesis
#YAP & Wnt signaling suppressed by (naturally or artificially) elevated Hydrostatic pressure during embryonic cavity #Blastocoel formation
#NatureCellBio 2024
www.nature.com/articles/s41...
Epithelial Zonation of 👦🐭small intestine
scRNAseq
5 (instead of 3) zones▶️Nutrient metabolism
3 Lgr5+ #IntestinalStemCell populations▶️a Hoxb7/8/9+ subset
ChEA3+SCENIC▶️transcrptional control of intestinal domains
#NatureCellBio 2024
www.nature.com/articles/s41...
