Endothelial Cell Competition in #VenousMalformation
Hyper-proliferative Tie2-L914F mutant ECs secret Semaphorin 3A & 3F to repel wild-type counterparts
Evidence from
1⃣mixed EC xenograft🐭
2⃣mixed ECs in 3D fibrin #Lumenogenesis
@boscololab.bsky.social #ATVB 2025
www.ahajournals.org/doi/10.1161/...
#EndothelialCell Mechanics & Dynamics in #Angiogenesis
Water influx & cytoplasmic viscosity
Mechanical plasticity ECM
#YAP/TAZ #CollectiveCellMigration
Luminal pressure & Curvature Sensing
Junction-LINC & vessel elongation
#Lumenogenesis
#CurrOpinCellBiol 2024
www.sciencedirect.com/science/arti...
#TightJunction maintains epithelial cell #Lumenogenesis via keeping Apical Junctional Tension at bay, Independent of Barrier functions👹
Pressure-tension relationships in ZO1/2 KO vs Claudin quin-KO MDCK-II cysts
@markusmukenhirn.bsky.social #Dev_Cell 2024
www.sciencedirect.com/science/arti...
#YAP #Lumenogenesis #EmbryonicCompetence 😎
Mechanosensitive #NeuralCrest induction in early #Embryogenesis
#YAP & Wnt signaling suppressed by (naturally or artificially) elevated Hydrostatic pressure during embryonic cavity #Blastocoel formation
#NatureCellBio 2024
www.nature.com/articles/s41...
PATJ, a Crumbs polarity complex protein,⏫epithelial cell #Lumenogenesis #Ciliogenesis
PATJ exhibits junctional+ciliary localizations, &⏬HDAC7, a ciliary protein
HDAC7 KD rescues morphogenetic defects of PATJ crispant MDCK cells
#CellMolLifeSci 2023
link.springer.com/article/10.1...
#EndothelialCell #Lumenogenesis
Decomposing the signaling role of endothelial tubulogenic cocktail (Insulin, FGF2, SCF, IL3, SDF1α)
α-tubulin level⏬in EC at 12-72 h in 3D collagen hydrogel w/o SCF/IL3/SDF1α😮
Dr. George Davis lab #AJPathol 2023
www.sciencedirect.com/science/arti...?
#ClathrinLightChain CLCa in uterine epithelial Barrier & #Lumenogenesis
Clta, not Cltb KO,🐭->
#Pyometra/Uterine infection
⏬Uterine glands
⏫FoxA2 in uterine luminal epithelia
Normal Mucin1 Barrier & Junctions
Frances Brodsky lab #LifeSciAlli 2023
www.life-science-alliance.org/content/7/1/...
