INduced Pdgfrb+ #Pericyte ITGA8 KO🐭

Baseline by 40 d
⏬microvascular pericytic coverage
⏬ #EndothelialCell #TightJunction
⏬ #BloodBrainBarrier
⏬EC-Pericyte N-cad junction
⏫Degenerated neurons
⏫Neurobehavioral anomalies

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in🐭Natural #Aging (18-mo) or D-galactose (for 8 wk)

Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands.

#AgingCell 2025
onlinelibrary.wiley.com/doi/full/10....

#TightJunction maintains epithelial cell #Lumenogenesis via keeping Apical Junctional Tension at bay, Independent of Barrier functions👹

Pressure-tension relationships in ZO1/2 KO vs Claudin quin-KO MDCK-II cysts

@markusmukenhirn.bsky.social #Dev_Cell 2024
www.sciencedirect.com/science/arti...

#EndothalialCell #TightJunction #AorticDissection

In🐭BAPN
Thoracic aortic endothelial permeability⏫at day 5, before any macroscopic dissection

AT-1001, PAR2 inhibitor, reseals ZO-1 TJ ⏬aortic permeability (70 kD) ⏬incidence of dissection by >50%

#AortaEd
#EHJ 2023
academic.oup.com/eurheartj/ar...

Loss of Lamininα5 from Both Tie2+ #EndothelialCell & PDGFRβ+ #Pericyte compromises #BloodBrainBarrier #BBB

Intact #TightJunction
Intact AQP4+ Astrocyte endfeet
⏫#Transcytosis ⏫Cav1 ⏬MFSD2A
⏬🧠pericyte

#FBCNS 2024
fluidsbarrierscns.biomedcentral.com/articles/10....