Histone and non-histone (de)acetylation impact on the blood-brain barrier #BBB

A nice literature source🤓

Table 2 HADC inhibitors & SIRT activators on trial

Joana Bicker lab #FBCNS 2026
link.springer.com/article/10.1...

Dual channel hiPSC 5-Cell Brain-on-a-chip to model Alzheimer's disease

healthy APOE3 vs late-onset APOE4

Vascular Channel: Endothelial cell
Brain Channel: Neuron, Astrocyte, Microglia, Pericyte

Permeability assay

Aβ42 Tau in cells & efflux

#FBCNS 2026
link.springer.com/article/10.1...

APOE2/3/4 isoforms or APOE KO in #hiPSC-derived isogenic #EndothelialCell #Pericyte & #Amyloidβ

EC
APOE2 ▶️highest transendothelial transport of Aβ42

Pericyte
APOE4 ▶️highest extracellular deposit Aβ42
APOE2 ▶️highest internalized Aβ42

#FBCNS 2024
fluidsbarrierscns.biomedcentral.com/articles/10....

Loss of Lamininα5 from Both Tie2+ #EndothelialCell & PDGFRβ+ #Pericyte compromises #BloodBrainBarrier #BBB

Intact #TightJunction
Intact AQP4+ Astrocyte endfeet
⏫#Transcytosis ⏫Cav1 ⏬MFSD2A
⏬🧠pericyte

#FBCNS 2024
fluidsbarrierscns.biomedcentral.com/articles/10....