β1-integrin acetylation in #EndothalialCell adhesion, junctions & proliferation

K794Q acetylation-mimetic β1-integrin
👉immature fibrillar adhesions
👉destabilizes VE-cad junctions
👉relieves contact inhibition of proliferation

@cp-iscience.bsky.social 2024
www.cell.com/iscience/ful...

Evidence for an active role of #EndothalialCell in #Aortopathy

EC TRPV4 activity⏫
🐭#AbdominalAorticAneurysm (local elastase)
via⏫EC #Apoptosis (how does this propagate to #SmoothMuscleCell loss) w/o altering #NitricOxide

#AortaEd
#EurJPharmacol 2024
www.sciencedirect.com/science/arti...

#EndothalialCell transcriptional regulator in👤#HeartFailure

26 WGCNA modules, module 17/21/22/23 Neg corr. with heart failure trait

3 transcription factors in VEGF-responsive module 23
CASZ1
ZNF532
NFE2L1/NRF1

#ajpheartcirc 2024
journals.physiology.org/doi/abs/10.1...

#EndothalialCell #TightJunction #AorticDissection

In🐭BAPN
Thoracic aortic endothelial permeability⏫at day 5, before any macroscopic dissection

AT-1001, PAR2 inhibitor, reseals ZO-1 TJ ⏬aortic permeability (70 kD) ⏬incidence of dissection by >50%

#AortaEd
#EHJ 2023
academic.oup.com/eurheartj/ar...