Single-cell Proteomics🔥 #MarfanSyndrome
Aortic Root
Fbn1 C1041G/+🐭

2.4k proteins
3.5k cells
487 proteins/cell👈

7 Smooth Muscle Cell subtypes
Prss2, Lrp1 as modulated SMC markers

vs scRNAseq

+SeqIF (21 Ab)

#AortaEd
Sarah Parker lab #MolCellProteomics 2026
www.mcponline.org/article/S153...

Loss of contractile phenotype (⏬SMMHC SMTN ⏫S100A4 MMP2) of #SmoothMuscleCell & Elastin fiber in #AcuteAorticDissection

Type A/B? Any aneurysm?🧐

24 case (non-monogenic) vs 17 control

"aortic wall adjacent to the entry site of the dissection"

#AortaEd
#CJCOpen 2025
www.cjcopen.ca/article/S258...

Histopathologic assessment of N=78 (14♀️64 ♂️) fatal aortic catastrophe (Rupture-/+Dissection)

58 cases involving ascending aortas, only 28 with > φ 4.0 cm

Hemopericardium/Cardiac tamponade in all cases examined

Proteoglycan dep in 51/78 (65%) cases

#AortaEd
#tjtcvs 2026
tjtcvs.org/articles/sud...

Transcript signature of lineage-specific mouse proximal thoracic aortic #SmoothMuscleCell

Wnt1-Cre cardiac neural crest (inner media)-derived SMC
vs
Mef2c-Cre second heart field (outer media)-derived SMC

#AortaEd
David Dichek lab #ATVB 2025
www.ahajournals.org/doi/10.1161/...

Aortic arch Height as an independent risk factor for acute type B #AorticDissection
113 case + 113 ctrl

3D CT measurement of Width (not the same as Diameter), Height, Angle of ascending aorta & aortic arch

#AortaEd
#SciRep 2025
www.nature.com/articles/s41...

Extra-Aortic Arterial Aneurysms in Loeys-Dietz Syndrome

N=103, 60 families (1998-2023)

42% subjects have 77 aneurysms➡️17 aneurysms lead to clinical events (rupture/dissection/repair)

#AortaEd
Alan Braverman lab #JACC 2025
www.sciencedirect.com/science/arti...

1400W, an iNOS inhibitor, reduces #ThoracicAorticAneurysm #ThroacicAorticDissecion in BAPN mouse, in addition to previously reported Marfan mice

A possible role in #SmoothMuscleCell Mitochondrial fission/fusion

#AortaEd

#EurJPharm 2025
www.sciencedirect.com/science/arti...

Sealing endothelial tight junction to prevent #ThoracicAorticDissection
#AortaEd

👤TAAD
⏬ZO-1
⏬scRNAseq Junction

🐭+BAPN
⏬ZO-1
⏫Aortic permeability (dextran-DOTA-Gd MRI)
👉Aneurysm Dissection Rescued by AT-1001 PAR2i

EC ZO-1 KO🐭+BAPN
⏫Aneurysm Dissection

#EHJ 2023
academic.oup.com/eurheartj/ar...

#AortaEd 🚨
Calcium channel blockers (dihydropyridines benzothiazepines phenylalkylamines) use is associated with ⏫risks of thoracic aortic aneurysm/dissection & abdominal aortic aneurysm in hypertensive👤

UKbio N=140k
13.5 y f/up▶️4327 case

+🐭evidence

#NatComms 2025
www.nature.com/articles/s41...

Amazing - Human Aortas can be cryopreserved at -80 °C with 10% DMSO for 12 months with histological (elastin, SMC, EC) & mechanical (subfailure stress, max stress, low/high stretch moduli) integrity largely retained

#AortaEd
#JTissEng 2025
journals.sagepub.com/doi/10.1177/...

#BicuspidAorticValve prevalence (6% vs 1~2% in general population) & related aortic outcomes in heritable #Aortopathy (TGFB 7 genes; ECM 7 genes; SMC contractile 5 genes; Other genes: HCN4 SLC2A10)

#MontalcinoAorticConsortium
N=816

#AortaEd
medRxiv 2025
www.medrxiv.org/content/10.1...

#AortaEd
#Diabetes

⬆️HbA1c level (even in normal range) is associated with ⬇️asc/desc thoracic aortic diameter & ⬇️risk for Aneurysm/Dissection

Multi-omics #UKBiobank Mendelian Randomization analyses➡️a causal link b/w glycemic traits / #T2D & TAAD risk

#JACCBTS 2025
www.jacc.org/doi/10.1016/...

Female has a larger (normalized) ascending aorta than male when dissected

146♀️+267♂️ Acute type A #AorticDissection
On average, dissection occurs at < 50 mm diameter

Aortic height index 28.7 vs 27.2 mm/cm
Aortic BSA index 25.7 vs 22.97 mm/m2

#AortaEd
#HeartBMJ 2025
heart.bmj.com/content/earl...

Regionalized & Sex-dependent scRNAseq of 🐭Aorta

Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell

Arch
#SecondHeartField vs #NeuralCrest SMC

339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS

#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...

Versican, but not Aggrecan, ➡️⏫AKT-iNOS➡️⏫🐭Fbn1C1041G/+ #MarfanSyndrome

Vcan, but not Acan, hetero KO ⏬#AorticAneurysm of Marfan🐭

Lentiviral shVcan start⏬ascending & abdominal aortic diameters in 3 days!!🥸

#AortaEd
#EmboMolMed 2024
www.embopress.org/doi/full/10....

#EASummit2025 Highlight 📸

We were pleased to welcome the team at Vascular News to the exhibition. Thank you for your contributions to our inaugural summit, and we look forward to collaborating in the future 🫱🏼‍🫲🏻

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd #MedicalConference

Partial aortic endothelial detachment from disorganized internal elastic lamina, + #EndothelialCell α5⏫ β1⏬ integrin, in a🐭#MarfanSyndrome model mgΔlpn/+ 6-mo♂️ (Already #AorticAneurysm...)

#AortaEd
#SciReports 2025
www.nature.com/articles/s41...

#EASummit2025 Highlight! 📸

We were pleased to welcome Prof. Joseph Coselli, Baylor College of Medicine, to deliver two talks. Thank you for your contributions to the Summit, Prof. Coselli! 👏🏼

#Aortic #Cardiovascular #Radiology #Anaesthesia #AortaEd #MedicalConference #InterventionalRadiology

Over the next few weeks, we’ll be revisiting some highlights from #EASummit2025 📸

First up is our Summit Dinner, which was held at the Playfair Hall – an incredible backdrop!

Keep an eye out for more information on #EASummit2026 👀

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd

#m6A #SmoothMuscleCell #Ferroptosis #ThoracicAorticAneurysm
#AortaEd

🐭TAA (ANGII+hi cholest diet)➡️
⏫arterial MDA iron
⏬GSH GPX4 SLC7A11
⏫ASCL4
rescued by Liproxstatin-1 or shMETTL14

METTL14/IGF2BP2➡️m6A stabilize ACSL4 mRNA➡️SMC ferroptosis

#AJPCellPhys 2025
journals.physiology.org/doi/full/10....

We would like to take this opportunity to congratulate Mr. Alsadeg Bilal on winning the Best Abstract Award at Edinburgh Aortic Summit 2025 - sponsored by Vessel Plus! 🏆

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd #MedicalConference #InterventionalRadiology #MedEd #MedTech

Arterial vs Aortic Events in #HeritableThoracicAorticDisease
N=1790
#VascularEhlersDanlosSyndrome
#LoeysDietzSyndrome
#MarfanSyndrome

Risk by 40 y/o
Arterial
♂️vEDS>LDS~MFS
♀️vEDS~LDS>MFS

Aortic
TGFBR2>FBN1>TGFBR1~TGFB2>COL3A1~SMAD3

#AortaEd
#JACC 2025
www.sciencedirect.com/science/arti...

#AortaEd #OpenScience

Supporting BHF Nurses with Aortic Dissection Specialist Knowledge The aortic dissection charity is partnering with the BHF to improve cardiac nurse training and support for those affected by aortic dissection.

Thank you to @thebhf.bsky.social for hosting us at today’s Cardiac Nurses #AortaEd Day. Proud to share our expertise on aortic dissection to strengthen the Heart Helpline. Delivering what patients want: clear info and compassionate support.
aorticdissectioncharitabletrust.org/strengthenin...

Sex-specific Mortality after Surgery for Acute Type A #AorticDissection
#AortaEd

327♀️+ 551♂️

30-d/In-hosp mortality ♀️20.5% vs ♂️18.5%

Long-term (6.2 y f/up) mortality ♀️4.1% vs ♂️2.6% per patient-year over 10 y
♀️Age COPD CKD #AorticAneurysm
♂️Age MI

#JTCVSOpen 2025
www.jtcvsopen.org/article/S266...

#HereditaryHemorrhagicTelangiectasia with #JuvenilePolyposis #CaseReport
#AortaEd

Among 57 patient with SMAD4 mutation HHT with

2 #TypeAAorticDissection
3 #ThoracicAorticAneurysm (10 dilatation)

+Mitral valve phenotypes

#Angiogenesis 2025
link.springer.com/article/10.1...

Thank you to everyone who has joined us over the past few days for the Edinburgh Aortic Summit! 🫀

We hope you had a wonderful time joining us at the inaugural event - make sure to share your experience with us using #EASummit2025

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd

Thank you to those of you who joined us for day one of #EASummit2025

We look forward to welcoming you to the Summit Dinner this evening, taking place at the Playfair Hall.

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd #MedicalConference #InterventionalRadiology #MedEd #MedTech

Welcome to all those who are joining us for day one!

Registration opens at 8am, with the opening address being delivered by the Chairman, Mr. Orwa Falah, at 8:45am.

Make sure to share your pictures with us using #EASummit2025!

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd

Speaker highlight at #EASummit2025!

We are pleased to be welcoming Dr. Ian Young to the inaugural summit!

🔗 easummit.org.uk

#Aortic #Vascular #Cardiovascular #Radiology #Anaesthesia #AortaEd #MedicalConference #InterventionalRadiology #MedEd #MedTech