Sealing endothelial tight junction to prevent #ThoracicAorticDissection
#AortaEd

👤TAAD
⏬ZO-1
⏬scRNAseq Junction

🐭+BAPN
⏬ZO-1
⏫Aortic permeability (dextran-DOTA-Gd MRI)
👉Aneurysm Dissection Rescued by AT-1001 PAR2i

EC ZO-1 KO🐭+BAPN
⏫Aneurysm Dissection

#EHJ 2023
academic.oup.com/eurheartj/ar...

Matrix & Adhesion defects, but Not #SmoothMuscleCell contractile dysfunction, account for pressure-induced #ThoracicAorticDissection in🐭+short-term TGFβ suppression

11-wk Myh11-CreERT2::Tgfbr1/2 f/f🐭 + Tmx + norepinephrine

#AortaEd
@jci-insight.bsky.social 2025
insight.jci.org/articles/vie...

A SGK1-#SIRT6-MMP9 cascade in #SmoothMuscleCell in #ThoracicAorticDissection

SMC Sgk1 KO,or GSK650394 (SGK1i)🐭➡️
⏬Thoracic aortic dilation
⏬#AorticRupture incidence

"SGK1 phosphorylates SIRT6 &⬆️its ubiquitination/degradation"

#ATVB 2024 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...