#SIRT6 #VascularCalcification

Rat #HighFatDiet + VitD3 + Nicotine
▶️Aortic medial calcification & ⏬SIRT6

SIRT6 overexpression ⏬Palmitic acid-induced #SmoothMuscleCell Apoptosis & Osteogenesis

#JHyperten 2023
journals.lww.com/jhypertensio...

SIRT6 drives protein synthesis via nucleolar remodeling in aging

Explore more at the 11th Edition: Global Congress on Aging & Gerontology
April 20–21, 2026 | Dubai, UAE

agingnlongevity.com

#AgingResearch #SIRT6 #Proteostasis #Longevity #MolecularBiology #DubaiEvents

Preliminary results indicate that treated animals demonstrated ‘superior survival’ and functional improvements compared to the control group.

vist.ly/4rcw4

#longevity #healthspan #SIRT6 #dogs

Targeting Delivery of Cyanidin‐Loaded With Ti3C2 Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease Vascular calcification significantly elevates cardiovascular risk in CKD patients, yet no effective therapies exist to halt its progression. We developed a dual targeting nanoplatform Ti3C2/RANKL/OCN...

#Review in #MedComm_Biomaterials_and_Applications
Targeting #Delivery of Cyanidin-Loaded With Ti3C2 #Nanosheets for Alleviating Vascular Calcification in Chronic Kidney Disease doi.org/10.1002/mba2...

#CardiovascularDisease #Cyanidin #NoninvasiveNanoprobes #SIRT6

How SIRT6 Could Shape the Future of Longevity SIRT6 supports DNA repair, energy balance and healthy aging. Learn why this tiny enzyme is exciting researchers and how seaweed-derived fucoidan fits in.

🌿 Imagine aging slower by supporting a single cellular repair enzyme. Meet SIRT6.

#SIRT6 #Longevity #Biohacking #HealthyAging #CellularHealth

Published in Bone Research, a study showed that SIRT6 loss disrupted cellular balance, triggering inflammation, chromatin changes, DNA damage, and signs of premature cellular aging.
#intervertebraldiscdegeneration #Sirt6
Details: doi.org/10.1038/s41413-025-00422-3

Immunic to Showcase Innovations in Biotechnology at Upcoming Conferences This May Immunic, Inc. will present groundbreaking research at various scientific conferences. Key topics include treatments for celiac disease and multiple sclerosis, showcasing their commitment to advancing biotechnology.

Immunic to Showcase Innovations in Biotechnology at Upcoming Conferences This May #None #Immunic_Inc #IMU-838 #SIRT6

Sirtuin 6 is a histone delactylase Histone lactylation (Kla) is a post translational modification (PTM) that is derived from metabolic lactate. Histone Kla has been extensively studied in the field of inflammation resolution and macrop...

"In cells treated with 25 mM lactate, the changes
in Kla due to Sirt6 were much more pronounced. In these cells, histone Kla was inversely proportional to
the amount of Sirt6 expression in the cell (Figure 5I)" www.biorxiv.org/content/10.1... #SIRT6 #aging #cancer #histones #Kla

CircRNAs? 🤔

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social
doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

Genflow begins SIRT6 gene therapy trial in dogs Trial aims to demonstrate capacity to extend healthspan in older animals as company continues to progress towards human trials.

Genflow begins SIRT6 gene therapy trial in dogs
Trial aims to demonstrate capacity to extend healthspan in older animals as company continues to progress towards human trials.
#longevity #healthspan #SIRT6 #dogs

#SIRT6 #AlzheimersDisease

#AmyloidPrecursorProtein as a deacetylase target of SIRT6➡️ubiquitin-proteasomal degradation

MDL-800, (Sirt6 activator)
⏬Cortical + Hippocampal APP Aβ40 Aβ42
⏫Cognitive behaviors Nest-building/NOR/Water maze
in APP/PS1🐭

#SciSignal 2024
www.science.org/doi/10.1126/...

#Sirt6 #Senescence #AbdominalAorticAneurysm

Human mouse AAA IHC
⏫SMC senescence
⏬Sirt6

Sirt6 transgene in Apoe-/-🐭 +Angiotensin II➡️
⏬p21 (not p16)-mediated Aortic senescence
⏬Inflammation
⏬Adventitial #Angiogenesis

#Atherosclerosis 2024
www.atherosclerosis-journal.com/article/S002...

#SGLT2i #SIRT6 #CardicFibrosis

#Empagliflozin #Dapagliflozin suppresses Angiotensin II- or TGFβ1-induced myofibroblastic differentiation of neonatal🐭cardiac fibroblasts

Partially via⏫Sirt6 expression (how?🧐) ⏬Nox4-ROS

#SciRep 2024
www.nature.com/articles/s41...

#SIRT6 transgenic overexpression⏬#AbdominalAorticAneurysm in Apoe-/-🐭+ #AngiotensinII

AAA endpoints rescued by Sirt6 OE->
⏫p21, but not p16 (which cells?)
⏫Mɸ or neoangiogensis

A possible SIRT6 role in #SmoothMuscleCell #Senescence SASP

#Atherosclerosis 2024
www.sciencedirect.com/science/arti...

#Sirt6 #Asthma

RORγt as a deacetylation target of Sirt6

Scgb1a1+ Epithelial Sirt6 drive IL-17A-dependent allergic airway inflammation+#EMT in🐭+#HouseDustMite+LPS

Sirt6 found high in🐭airway epithelia, modest in 🫁Mφ, low in EC/SMC

#NatureComms 2023
www.nature.com/articles/s41...

#Sirt6 #Cartilage Development #Aging #OsteoArthritis

Intra-articular injection of tgg2 (chondrocyte aptamer)-PP (PEGylated PAMAM: drug encapsulator)-MDL800 (Sirt6 activator) #Nanoparticle
Persist up to 40 d in normal🐭
⏬#Chondrocyte #Senescence+🐭OA (DMM)

#NatComm 2022
www.nature.com/articles/s41...

GATA6 as a pro-calcific/pro-senescent factor in #SmoothMuscleCell
via ⏬ATM->⏫DNA dmg

AAV9-SM22α-GATA6 shRNA⏬VitD3-induced 🐭#AorticCalcification+#SMC #Senescence

#SIRT6 deacetylates+destabilizes NKX2.5 protein->⏬GATA6 transcription

#KidneyInt 2023
www.sciencedirect.com/science/arti...

Pathogenic #SIRT6 in #Tuberculosis

Mycobacteria⏫Wnt-dep. G9a #HistoneMethyltransferase+#SIRT6 in Mφ->
Cholesterol genes ⏫biosynthesis/uptake ⏬Efflux ->
⏫Mycobacteria antioxidant+survival

G9a inhibitor or Sirt6+/-⏬🐭🫁Granuloma

#PLOSPathogens 2023
journals.plos.org/plospathogen...

Hepatic #SIRT6 #Atherosclerosis

AAV8-TBG-Cre;Sirt6 f/f
AAV8-ALB-hSIRT6

Functional features in
Liver: Steatohepatitis
Intestine: Lipid absorption; VLDL secretion
Adipose: Thermogenesis

Dr. Raja Gopoju, Xiaoli Pan, Yanqiao Zhang labs #CellsMDPI 2023
www.mdpi.com/2073-4409/12...

#Sirt6 #Ovary

#Sirt6 KO🐭->
Ovarian hypoplasia (How?)

1⃣Aberrant ovarian folliculogenesis, trapping at primary follicle status, ⏬follicle collagen thickness

2⃣⏬Estrogen synthesis by in vitro #GranulosaCell, but⏫plasma E/E2 in vivo

#AgingCell 2023
onlinelibrary.wiley.com/doi/10.1111/...

An interview with Dr Gorbunova, wherein she provides more details on fucoidan (it's actually a group of substances) and SIRT6 ribosylation activity -
youtu.be/VGKaa7dh2vg?...

#fucoidan #SIRT6

Vera Gorbunova at ARDD2023: Transcriptomic and proteomic signatures of longevity
youtu.be/DjYHihUfHq8?...
I ❤️ Dr Gorbunova
I ❤️ fucoidan

#LINE1 #retrotransposons #SIRT6 #fucoidan #aging #inflammation #NaturalProducts #FunctionalFoods

OsteoImmune Surveillance
⏬in #Aging
⏫by #Sirt6

Sirt6 in apoptotic osteoblast⏬CD47 (Don't eat me signal)+release of apoptotic #ExtracellularVesicle to attract Mφ

Sirt6 in Mφ⏫SIRPα+#Efferocytosis ability

J Cheng, H Jiang labs #AdvSci 2023
onlinelibrary.wiley.com/doi/10.1002/...