C. David Allis, born #OTD, was recognized for his discoveries elucidating how gene expression is influenced by chemical modification of #histones —the proteins that package #DNA within chromosomes. 🧬 The Rockefeller University
🧪 Read about it here: http://ow.ly/SFZ850NlrSz
2018 #LaskerLaureate Michael Grunstein was recognized for discoveries elucidating how gene expression is influenced by chemical modification of #histones —the proteins that package DNA within chromosomes. 🧪
https://ow.ly/NqJu50YcCuc
https://ow.ly/6L4n50YcCue
Epigenetics Update - Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability bit.ly/3NWpeB3
Joshua C. Saldivar in Mol Cell
#Epigenetics #Histones
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Discover the breakthrough at epigenometech.com
Epigenetics Update - Cell-cycle-dependent repression of histone gene transcription by histone H4 go.nature.com/4bjE521
Kami Ahmad and Steven Henikoff (Fred Hutchinson Cancer Center) reporting in NSMB
#Epigenetics #Histones
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Perfect for cancer, immunology, and aging research; epigenometech.com
#Archaeasky #Microsky #histones
New preprint from @samuelschwab.bsky.social @damelab.bsky.social
🌟 G&D SPOTLIGHT 🌟
RESEARCH PAPER: Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate
By Franklin et al., and Sihem Cheloufi
➡️ https://genesdev.cshlp.org/content/39/9-10/652.abstract
#histones #transcription #replication
Excessive Cell Growth Causes Cytoplasm Dilution and Contributes to Senescence #aging #osmosis #senescence
www.cell.com/cell/fulltex...
Bioelectricity is a universal multifaced signaling cue in living organisms
www.molbiolcell.org/doi/10.1091/...
#bioelectrical
(How does this change #histones?)
RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
➡️ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial.
rdcu.be/exXBX
our paper is online! rdcu.be/exXBX . Who would have thought that some #giantviruses not only have #histones, but even histone variants that make weird #nucleosomes (pdb 9CVT). Fantastic work from Ale Villalta and Chelsea Toner, with Hugo Bisio @molbiolgv.bsky.social and Chantal Abergel
🧬 What role do extracellular #histones play in #sepsis? Key mediators and biomarkers—promising for diagnosis & prognosis! 🧪Read more: shorturl.at/MMEl2
Now online - the Review "Histone-mediated chromatin organization in prokaryotes and viruses" from @samuelschwab.bsky.social @vikramalva.bsky.social @damelab.bsky.social and co.
#histones #DNAorganization #chromatin #eukaryogenesis
Read it here 👉 authors.elsevier.com/sd/article/S...
Circulating #histones as clinical biomarkers in critically ill conditions febs.onlinelibrary.wiley.com/doi/10.1002/... #hvhebron #mintens [Text complet]
📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox #DNA
emploi.cnrs.fr/Offres/CDD/U...
In @jcb.org, Tatsuya Hirano reviews mitotic genome folding with an emphasis on the mechanistic aspects of #condensins, #topoisomerase II, and #histones. rupress.org/jcb/article/...
#CellCycle #CellDivision #Genetics #Mitosis #Chromatin
Tatsuya Hirano reviews mitotic genome folding with an emphasis on the mechanistic aspects of #condensins, #topoisomerase II, and #histones. rupress.org/jcb/article/...
#CellCycle #CellDivision #Genetics #Mitosis #Chromatin
Un gir #molecular, un canvi #epigenètic a les #histones, permet a les cèl·lules #intestinals bascular entre dos estats: diferenciat funcional i desdiferenciat regenerador. La signatura epigenètica dona identitat i plasticitat.
Cell Science 2025,
email.labxmediagroup.com/e3t/Ctc/LT+1...
"In cells treated with 25 mM lactate, the changes
in Kla due to Sirt6 were much more pronounced. In these cells, histone Kla was inversely proportional to
the amount of Sirt6 expression in the cell (Figure 5I)" www.biorxiv.org/content/10.1... #SIRT6 #aging #cancer #histones #Kla
CircRNAs? 🤔
📣 During #spermiogenesis, #chromatin in germ cells undergoes significant condensation, with most #histones being replaced by a species-specific ratio of Protamin1 and Protamin2.
Altered PRM1/PRM2 ratios are associated with #subfertility and #infertility.
Carnivalistic Protein Art
Protein: Histone chaperone RbAp46 (www.rcsb.org/structure/3cfs)
Drawing: Cologne Fools’ Guild
This protein helps to organize #histones, the spools around which DNA is wrapped, and regulates genes involved in cell growth and transition.
#Carnival #Cologne #ProteinArt
Finally! The outstanding review by Felix Diegmüller(@felixdiegmueller.bsky.social) & Jörg Leers is out in JBC!
Written for a special issue honoring C. David Allis, it highlights his groundbreaking work on histone variants and recent discoveries in H2A.Z biology!
#Epigenetics #Histones #Chromatin
Epigenetics Update - Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability bit.ly/41lcGGC
Anja Growth (Univ. Copenhagen) in Science Advances
#Epigenetics #Histones
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Gain high-resolution insights with epigenome.us
Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.
#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B
phys.org/news/2025-02...
Text reads: News - Repressed but ready to go: how intricate molecular interactions establish responsiveness to gene expression cues that shape development. Image shows two immunofluorescence images of embryonic stem cells cultured to differentiate into neurons. The bottom image show the effect of a gene deletion on the ability of the cells to differentiate into neurons, demonstrated by the loss of a neuron-specific protein identified by green immunofluorescence. Blue shows DNA.
RESEARCH NEWS: #epigenetics research from the Voigt lab uncovering "a key mechanism that has so far eluded experimental scrutiny."
Thursday reading for anyone interested in #BivalentDomains #Histones #GeneRegulation in development #ESCs 🧪
www.babraham.ac.uk/news/2025/02...
Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹
Register now: ➡️ shorturl.at/AtAjz
Exciting speaker lineup, many slots for talks selected from abstracts
It is still possible to apply to this postdoc position in my group if you are motivated by using your QM/MM and MD skills to study the fascinating histone post-translational modifications! 🥳
Deadline is the 1st of March #job #compchem #histones #DNA
Apply on the CNRS website : lnkd.in/eNxR-TPH
Most excitingly, we discuss current evidence in support of the idea that #histones have yet unknown cell biological functions outside the cell.
In this Review article, we discuss the "non-canonical" locations and (path)physiological functions of #histones, the known mechanisms of their release from the nucleus and the cell and the known mechanisms through which they are sensed by other cells.
Most notably, #histones have important roles in #immune defence as highly potent #antimicrobial agents.
In fact, release of extracellular #chromatin is nearly as ancient and widespread as chromatin itself.
Far beyond their functions in genome packaging, organisation and regulation, #histones function to regulate cell #metabolism, act as messengers of #apoptosis and are even capable of catalysis.
