This #STTT study shows that hnRNPR regulates m6A-dependent #AlternativeSplicing of Skap2, positioning it as a key regulator of #Spermiogenesis, while highlighting mEVs-SKAP2 as a promising #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...

📣 During #spermiogenesis, #chromatin in germ cells undergoes significant condensation, with most #histones being replaced by a species-specific ratio of Protamin1 and Protamin2.
Altered PRM1/PRM2 ratios are associated with #subfertility and #infertility.