Experimental Drug Can Reverse #Osteoarthritis in Weeks, Animal Research Shows
www.sciencealert.com/experimental...
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Hashtag
#OsteoArthritis
Advertisement · 728 × 90
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#Periostin (#POSTN) drives #ChondrocyteHypertrophy and #osteoarthritis progression via #RUNX2 signaling, with its inhibition reducing #CartilageDamage, and hypertrophic gene expression, highlighting it as a therapeutic target for OA management.
#OpenAccess: doi.org/10.1016/j.ge...
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"Mast cells - infamous for secreting allergy-triggering chemicals - also secrete a cartilage-degrading enzyme..."
#Osteoarthritis #ChronicIllness #ChronicPain #MCAS #HolisticHealth #Acupuncture #TuiNa #LifestyleSupport 💕 #Wellness
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Measurement of quadriceps strength using a handheld dynamometer. Patients were seated with the knee at 90° flexion. Quadriceps strength was measured isometrically with a handheld dynamometer (μTas F-1, Anima Corporation, Japan) secured to the distal lower leg using a strap with belt stabilization.
Achieving quadriceps strength within the distribution of older adults without knee OA following TKA is associated with clinically meaningful differences in satisfaction and functional activities.
#Osteoarthritis #Arthroplasty #Knee #Quadriceps #Muscle #OrthoSky #MedSky
ow.ly/9CHK50YEZ7I
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Dear Bsky Friends, prevention of #frailty & unintentional weight loss + adoption of vigorous #exercise + #smoking-cessation for knee- & hip #osteoarthritis? Open access: authors.elsevier.com/c/1ms3X8nLVi...
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#Key #protein found to #protect #cartilage, offering new hope for #osteoarthritis #treatment
Researchers found SHP protein protects cartilage by blocking degrading enzymes. Gene therapy restoring SHP levels greatly reduces pain and joint damage in OA scitechupdates.com/k...
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CRISPR/CasRx-mediated RNA knockdown of β-catenin and Ihh signaling effectively alleviates osteoarthritis.
#CRISPR #CasRx #BetaCatenin #Ihh #Osteoarthritis #RNAEditing #CartilageRepair
www.sciencedirect.com/science/arti...
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Submit your work in orthopedics, cartilage biology, bone metabolism, or musculoskeletal disease to Genes & Diseases.
#BoneResearch #Osteoarthritis #Osteoporosis
Submit here: www.editorialmanager.com/gendis/
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This week, Genes & Diseases highlights advances in orthopedics—from osteoarthritis mechanisms to osteoporosis pathways and chondrodysplasia therapeutics.
#Orthopedics #BoneResearch #Osteoarthritis #Osteoporosis
www.keaipublishing.com/en/journals/...
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📘 The April issue is now available.
Explore new peer-reviewed research and clinical insights in the latest issue of @jrheumatol.bsky.social.
🔗 www.jrheum.org/content/53/4...
#RheumatoidArthritis #Spondyloarthritis #PsoriaticArthritis #Lupus #Vasculitis #Osteoarthritis #InterstitialLungDisease
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Welp, the good news is that I don't have osteoarthritis in my left knee.
#osteoarthritis #arthritis #goodnews
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Holy shit this would be amazing. As someone who would need two new knees at some point, I would MUCH rather do this. #osteoarthritis
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GIFT ARTICLE
With funding from ARPA-H, three teams of researchers have regrown bone and cartilage, even entire knees, in animal studies. Human trials are not far off. #osteoarthritis
www.nytimes.com/2026/04/06/h...
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Dr. Benjamin Alman in a laboratory setting
Imagine activating the body’s natural process to heal damage from #osteoarthritis. Read about a Duke Health-led effort’s major milestone bringing the approach toward first-in-human clinical trials: duke.is/r/sfnz
@dukemedschool.bsky.social | @bostonchildrens.bsky.social | @harvardmed.bsky.social
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“inhibition of 15-PGDH—an enzyme that drives tissue aging, a “gerozyme”—leads to cartilage regeneration in aged mouse OA joints, in joints of young adult mice with posttraumatic OA (PTOA) resulting from an ACL tear” #osteoarthritis www.science.org/doi/10.1126/...
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Allocetra moves into Phase 2b as Enlivex targets one of aging’s most common and most overlooked mobility killers.
Link as first comment.
#longevity #geroscience #osteoarthritis #biotech #clinicaltrials
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JHC's Newest Article: "Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis."
Click to read: journals.sagepub.com/doi/abs/10.1...
#osteoarthritis #cartilage #immunohistochemistry
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Writing for Healthcare Today, Philip Lindsell, managing director of Flarin, discusses the challenges of joint pain relief in an era of active living.
healthcaretoday.com/article/comm...
#Healthcare #PublicHealth #JointPain #Osteoarthritis #InflammatoryConditions #PatientSafety
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💊 Rheological properties and clinical efficacy of a chemically modified hyaluronic acid for joint health enhancement
Benazzo & Bernetti
#osteoarthritis #HyaluronicAcid #rheumatology #aging
@me.pharmsky.app @medsky.social
Read the full article here: www.drugsincontext.com/rheological-...
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CRISPR/CasRx-mediated dual knockdown of Ctnnb1 and Smo effectively suppresses Wnt/β-catenin and Ihh signaling to reduce #osteoarthritis progression, highlighting a promising RNA-targeting #GeneTherapy strategy for OA treatment.
#OpenAccess: doi.org/10.1016/j.ge...
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#Osteoarthritis (OA) often coexists with metabolic traits (MTs), causing significant disability. 🧬
Liao et al. aimed to uncover the shared genetic mechanisms between OA and MTs, revealing novel OA-MT related genes, proteins and pathways.
Read more🔖:
www.oarsijournal.com/article/S106...
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🔗 Lubricin’s Mucin Domain Has Strong Polyproline Type II Helical Character. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0021 📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
🔗 Lubricin’s Mucin Domain Has Strong Polyproline Type II Helical Character. Computational and Structural Biotechnology Journal. DOI: doi.org/10.34133/csb...
📚 CSBJ: spj.science.org/journal/csbj
#StructuralBiology #ProteinScience #Biophysics #ComputationalBiology #Osteoarthritis #Glycoproteins
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Osteoarthritis affects millions. Emerging studies show that metformin may reduce inflammation, support joint health, and even slow structural damage.
🔗 Learn more: www.parsemus.org/2026/02/metf...
#Metformin #Osteoarthritis #HealthResearch #EvidenceBasedMedicine #PublicHealth #MedicalInnovation
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Excited to share that the UCSF Collins Lab will be presenting at #ORS2026 this week in Charlotte!
If you’re interested in learning about spatial transcriptomics, fat–joint crosstalk, or aging-associated #osteoarthritis, we would love to connect - reach out or stop by! 💫
#science #ortho #fatchat
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Excited to share the Collins Lab Lineup for #ORS2026 🎉
From spatial transcriptomics to fat-joint crosstalk in #osteoarthritis, our team is presenting talks & posters all weekend long 🎤
Stop by my NIRA poster & podium on Sunday morniny to learn more about the role of fat in OA & #aging 🧬
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🧬 Not the iPS cells — but the liquid they were grown in.
Injected into arthritic knees: 71.4% improved. Zero side effects.
A world-first clinical study that could help 375M people.
#iPSCells #RegenerativeMedicine #Osteoarthritis
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✔ PRP → better pain relief at 6 months. No long-term difference. No functional improvement
Takeaway: PRP helps… but not consistently. Is PRP worth the cost in your setting?
Read more: www.cureus.com/articles/184...
#Cureus #Orthopedics #Osteoarthritis #MedSky
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New #OMICs work by Barter et al. seeks to reveal the chromatin accessibility of the #cartilage chondrocyte genome and identify changes that occur in accessibility during both development from mesenchymal stem cells (MSC) and in #osteoarthritis (OA).
🔗: www.oarsijournal.com/article/S106...
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Fellow OA patients, this is the time when you remember Vioxx and today's 15 year destruction of patient care due to opiate hysteria, that turned patient care into anesthesiologist/cop care.
#chronicillness
#rheumatology
#osteoarthritis
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