#Periostin (#POSTN) drives #ChondrocyteHypertrophy and #osteoarthritis progression via #RUNX2 signaling, with its inhibition reducing #CartilageDamage, and hypertrophic gene expression, highlighting it as a therapeutic target for OA management.
#OpenAccess: doi.org/10.1016/j.ge...

IRE1α (encoded by ERN1) negatively regulates postnatal growth plate development by accelerating #ChondrocyteHypertrophy & #CartilageMineralization via impairing homeostasis of the crucial IHH and PTHrP/PTH1R feedback loop & #ERstress. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

New study shows that miR-101a regulates #ChondrocyteHypertrophy via Cox-2 & Col10a1, leading to delayed #Hypertrophy & #CartilageDegeneration, spotlighting it as a negative regulator of #Osteoarthritis. #medsky @uchicagocancer.bsky.social
#OpenAccess:
www.sciencedirect.com/science/arti...

#Mapk7 deletion in the cartilage of the Col2a1-Cre; Mapk7f/f mouse model impaired #ChondrocyteHypertrophy of the vertebral growth plate via inhibition of MEF2C/PTEN/AKT signaling, resulting in severe vertebral defects, including #Kyphosis and #Osteopenia. #medsky