#Periostin (#POSTN) drives #ChondrocyteHypertrophy and #osteoarthritis progression via #RUNX2 signaling, with its inhibition reducing #CartilageDamage, and hypertrophic gene expression, highlighting it as a therapeutic target for OA management.
#OpenAccess: doi.org/10.1016/j.ge...

A new therapeutic strategy for osteoarthritis emerges by targeting the AMPK–β-catenin–Runx2 signaling axis.
#Osteoarthritis #AMPK #BetaCatenin #Runx2 #CartilageDegeneration #OAPathogenesis
doi.org/10.1016/j.ge...