@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits
Stable, sustained support can transform your career:
Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen
BenchOS Equipment Booking
BenchOS drives E Ink paper displays to show equipment bookings.
Rendered E Ink paper display of AKTA ATLANTA equipment booking status.
Next BenchOS update: BenchOS contains an equipment booking system. E Ink displays automatically update and show the current equipment booking status of our instruments. Check out how this looks like for our AKTA Atlanta.
And integrate the information back into a private knowledgebase web app.
Abstract deadline extended to April 20 for the FASEB #UbiqSRC, colocated with the #ProtFoldSRC, June 1-4 in Louisville! Register for one of the ~20 talk slots throughout the main meeting and pre-meeting career forum!
events.faseb.org/event/Ubiqui...
BenchOS' cryo-EM storage tracker.
BenchOS is taking shape. Today, our cryo-EM storage tracker.
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵
🔗 www.nature.com/articles/s41...
#CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
Glückwunsch, Bruderherz! Really outstanding work by @bartellab.bsky.social and Schulman Lab. This is how transatlantic research is done 🇺🇸🇩🇪.
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
The longest-running UB/UBL conference, join @labjoazeiro.bsky.social and @sshaolab.bsky.social, for #UbiqSRC. Featuring keynotes by @idikic.bsky.social of @goetheuni.bsky.social with Jeff Kelly from @scripps.edu.bsky.social. Submit your abstract and register to join us in Louisville: buff.ly/uAY0w0M
This is neat. Do you reckon we will get end-to-end agentic structure refinement soon?
Is there documentation for Agentic Coot?
NYT feature on their website's front page about our local C. elegans colleague Will Mair and NIH funding
www.nytimes.com/2026/03/13/u...
Our lab is hiring a research technician! We are interested in reproduction, stem cells, and development. If you are seeking a robust 2-year career experience before the next chapter of your educational journey, this is the position for you!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Congrats, Roberto. Bringing biochemistry of transcription to the 21st century!
@triggerloop.bsky.social not to sidetrack you here but…
🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause
Calculate DNA absorption coefficients for single-stranded and double-stranded DNA: absorptiondna.farnunglab.com
Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...
BenchAid🧪 is so great that we even decided to build our own ELN (called LabBook) that we will share with the community soon. LabBook combines ELN and lab registry to make many operations (like complex buffers for biochemical experiments) directly computable by BenchAid.
Your data stays on your machine*. SQLite database, local files, no cloud dependency. Full control. (*Non-local models will still result in the data being shared with the agent provider.)
One example where BenchAid really excels is the automatic checking of @plasmidsaurus.bsky.social sequencing results early in the morning:
🧪✨ Introducing BenchAid🧪! Our new molecular biology AI agent is live at benchaid.farnunglab.com. Over the last months, we built BenchAid🧪 to streamline many of our bench workflows to help move our lab faster. Try it out!
Happy to share part of my postdoctoral work at the @lucas.farnunglab.com lab. Great collaboration with @voslab.org and @andersshansen.bsky.social. “Structural basis for CTCF-mediated chromatin organization” www.biorxiv.org/content/10.6...
If you like our story here, consider applying to our labs for your post-doc! We have exciting projects ranging from transcription and DNA replication to genome organization and chromatin remodeling (and even lab automation and agentic molecular biology AI, more on this soon)!
This was a serendipitous finding with so many involved (👀 @voslab.org and @andersshansen.bsky.social). Especially proud of Farnung Lab contributors @mosorio91.bsky.social (on the job market) and PhD candidate Alex Stone. Biochemistry, structural biology, and cell-based assays (Micro-C!!!).
🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...
If you are looking for more history and inspiration from Freeman Hrabowski, his TED talk is very powerful. Well worth the 15 minutes.
www.ted.com/talks/freema...
2026 is young. Hopefully, there is going to be more exciting research to come!
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
