#SIRT6 #AlzheimersDisease

#AmyloidPrecursorProtein as a deacetylase target of SIRT6➡️ubiquitin-proteasomal degradation

MDL-800, (Sirt6 activator)
⏬Cortical + Hippocampal APP Aβ40 Aβ42
⏫Cognitive behaviors Nest-building/NOR/Water maze
in APP/PS1🐭

#SciSignal 2024
www.science.org/doi/10.1126/...