#Aging of Human Ovary
#SpatialTranscriptomics #Visium

Aged oocytes
⏫MDK-LRP1 signaling to EC/SMC/theca-stroma/T cell/NK (not Monocyte)

Aging of #GranulosaCell & Theca-Stroma
driven by⏬FoxP1

Ovarian SMC is Mustn1+😁

Cav1 as a #SASP component!?😮

#NatureAging 2024
www.nature.com/articles/s43...

#Sirt6 #Ovary

#Sirt6 KO🐭->
Ovarian hypoplasia (How?)

1⃣Aberrant ovarian folliculogenesis, trapping at primary follicle status, ⏬follicle collagen thickness

2⃣⏬Estrogen synthesis by in vitro #GranulosaCell, but⏫plasma E/E2 in vivo

#AgingCell 2023
onlinelibrary.wiley.com/doi/10.1111/...