Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proli...

#Review in #MedComm_Oncology
Multifacet Roles of Cellular #Senescence in #Cancer: Mechanisms and #Therapeutic Implications doi.org/10.1002/mog2...

#SASP #ImmuneActivation

Whole-body p21 transgenic🐭
#SkeletalMuscle atrophy fibrosis
⏬Treadmill Grip strength
SkM transcriptomic #Senescence #SASP
⏬OXPHOS
⏫myonuclei & interstitial cell #DNADamage

p21 OE does Not increase p16 in SkM

Nathan LeBrasseur lab #MolMetab 2023
www.sciencedirect.com/science/arti...

Call for Abstracts

p62 loss drives TIF-IA buildup, nucleolar change, and SASP inflammation

Key discoveries shaping our understanding of aging and longevity submit your abstract below:

agingcongress.com/edition2/abs...

#CellularSenescence#Proteostasis #Autophagy #Nucleolus #SASP

Targeting immunosenesence promotes clearance of senescent cells - Immunity & Ageing Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age. Cellular senescence is a crucial process that puts cells in an irreversible cell-cycle arrest which prevents damaged or stressed cells from uncontrolled propagation and eventually potential malignancy. Paradoxically, senescence also contributes to the occurrence of cancer and increases the risk of metastasis through different secretory mediators. Altogether, the recent use of senotherapy to eliminate senescent cells has been shown to delay tumorigenesis, attenuate age-related deterioration of organs, and promote healthy aging. Interestingly, immune cells have been shown to specifically interact with, and kill senescent cells, thus opening new opportunities for the development of specific therapeutic strategies similar to immunotherapy in cancer. Through its detrimental impact on the immune system, immunosenescence is also leading to the accumulation of senescent cells with age thus further contributing to the occurrence and worsening of multiple age-related pathologies such as cancer. Understanding the molecular and cellular events occurring during the aging process, and triggering immunosenescence as well as the mechanisms by which senescent cells escape immune surveillance would help to improve immune responses to senescent cells and their clearance. In this review, we highlight how senescent cells interact with immune cells, and how immunosenescence-associated phenotypical and functional deregulation hinder the ability of immune cells to clear senescent cells. We further characterize strategies aimed at promoting the clearance of senescent cells by the immune system.

Chronic #SASP production→ ↑ #inflammation. Accumulation of #senescent cells→ ↑ cancer and other age-associated pathologies. Targeting and clearance of senescent cells ↆ pathologies. bit.ly/46Sbu1r

老化の連鎖を制御するPPARの発見：美肌への新たな道 大正製薬が特定したSASP抑制因子PPAR。その発見が肌の老化を抑制し、美しい肌を保つ新たな研究成果を紹介します。

老化の連鎖を制御するPPARの発見：美肌への新たな道 #東京都 #豊島区 #大正製薬 #SASP #PPAR

大正製薬が特定したSASP抑制因子PPAR。その発見が肌の老化を抑制し、美しい肌を保つ新たな研究成果を紹介します。

Thanks colleagues at #SASP for an energising day, focused on how we reap the health benefits of getting our population moving

SYMPOSIUM OUTLOOK: The interplay between senescence, inflammation, and the immune system
By Jesús Gil
➡️ genesdev.cshlp.org/content/39/1...

#senescence #aging #immune #SASP #nucleicacid #inflammation #therapy #openaccess

Perspective: Zhu et al. discuss the rise of RAS: how gradual oncogene activation shapes the OIS spectrum @narita-lab.bsky.social
➡️ tinyurl.com/gd352761

#oncogene #cancer #senescence #SASP #physiology #tumorigenesis #tumor #RAS #NOTCH #dose #cellstate #inflammation #replicativestress #openaccess

¿Quién mejor que el alumnado para contar lo que es el #ABR Diseño Universal en la Gastronomía (DUG)?
youtu.be/jUyyfYSA-TQ?...

Si te pica la curiosidad y quieres saber en qué consiste este reto intermodular e interciclos aquí tienes la info: gafasdefol.com/diseno-unive...

#SASP #FOLcomparte #FP

5/13 Childhood cancer survivors have abnormally high levels of these senescent cells, likely due to their treatments. This drives loss of function, disease risk, and chronic inflammation. #SASP #DiseaseRisk #InflammatoryMolecules

#SASP

#FOLcomparte
Ayer tuvimos la inmensa suerte de escuchar a la gran Tamara @gafasdefol.bsky.social impartir un webinar sobre el nuevo módulo de #Sodtenibilidad
Q enriquecedoras e inspiradoras las propuestas q está trabajando en sus aulas... tanto de #SASP como de #EIE o #IPE
youtu.be/d4kc4kQspTM?...

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations - npj Aging npj Aging - Emerging insights in senescence: pathways from preclinical models to therapeutic innovations

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩‍🔬🧪🔬🥼👨‍🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent

Full details 👇 ✨️

www.nature.com/articles/s41...

Nueva por aquí y con ganas de encontrar el rincón que merece #FOLcomparte #FOL #FP #IPE #SASP #ClaustroVirtual ¿Te animas?

Targeting senescent cells in atherosclerosis: Pathways to novel therapies Targeting senescent cells has recently emerged as a promising strategy for treating age-related diseases, such as atherosclerosis, which significantly…

Targeting senescent cells in atherosclerosis: Pathways to novel therapies 👇👇👇 #cardiovascular #senescence #inflammation #ageing #SASP #cardiovasculardisease #atherosclerosis

www.sciencedirect.com/science/arti...

#HutchinsonGilfordProgeriaSyndrome

#Senescence/#Aging features of Isogenic HGPS #hiPSC-#EndothelialCell vs #SmoothMuscleCell

#Progerin <
Nuclear deformation <
#Senescence >
#DNADamage ~
#TelomereLength <
#Shelterin
#SASP
#Heterochromatin loss ~

#EHJOpen 2022
academic.oup.com/ehjopen/arti...

#LongNoncodingRNA #SmoothMuscleCell #Seneascence #Atherosclerosis

LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, transcriptionally activates #SASP in senescent SMCs

SMC Jpx KO⏬🐭#Atherosclerosis +⏬lesional SMC senescence SASP

#ATVB 2024
www.ahajournals.org/doi/10.1161/...

#Senescence Mechanobiology

#SASP of Fibroblasts▶️defective Nuclear Mechanics of Tumor cells
⏬Cortical tension ->
⏫Cytoplasm viscoelasticity (Intracellular loading of carboxylated 100-nm fluorescent beads)->
⏬Nuclear Volume->
⏫Nuclear Lobulation

#PNASNexus 2024
academic.oup.com/pnasnexus/ar...

#Aging of Human Ovary
#SpatialTranscriptomics #Visium

Aged oocytes
⏫MDK-LRP1 signaling to EC/SMC/theca-stroma/T cell/NK (not Monocyte)

Aging of #GranulosaCell & Theca-Stroma
driven by⏬FoxP1

Ovarian SMC is Mustn1+😁

Cav1 as a #SASP component!?😮

#NatureAging 2024
www.nature.com/articles/s43...

🗣 Students - registration is now open for our live WEBINAR: ‘Turning your Dissertation into a Research Article’. 5th & 8th May. Check your email for details and get ready to submit to the STER eJounal 📝💻 #EdResearch #SasP

ABOUT STER ⁉️
The STER eJournal publishes articles by UG & PG education students based on their dissertation research. Articles are peer-reviewed by an UG student team #STER2020 #SasP

Get involved or access articles here: http://www.ster.ie/journal

Student teacher articles for the STER eJournal are now available to read online: 🌐 http://www.ster.ie

🔜 We’ll be sharing article links & topics each week in the lead up to the #STER2020 Conference #EdResearch #ITE #SasP

Hard at work this lunchtime! Our student team (@MIEEdStudies @MIE_ECE #MIEPrimary) were peer reviewing articles for Vol.3 of #STER2020 eJournal! #PeerReview #SasP #EdResearch

Delighted to attend my first meeting as part of the National Advisory Group for Student Engagement (@NStEPie) today @hea_irl. Thrilled to have been appointed & looking forward to contributing to #SasP with @QQI_connect @TheUSI @hea_irl

Productive morning prepping training packs for the @STER_Ire team 2020! Looking forward to our first meeting @MarinoInstitute next week 👏 #FunkyFolders #SasP #STER2020