Finally out! We introduce NoLMseq, a #nucleolus laser microdissection method to capture single-cell genome-nucleolus interactions in normal and stressed nucleoli, revealing novel insights into genome organization & function. www.nature.com/articles/s41...

Call for Abstracts

p62 loss drives TIF-IA buildup, nucleolar change, and SASP inflammation

Key discoveries shaping our understanding of aging and longevity submit your abstract below:

agingcongress.com/edition2/abs...

#CellularSenescence#Proteostasis #Autophagy #Nucleolus #SASP

New tool allows researchers to track assembly of cells’ protein-making machines With a new mapping tool, Princeton engineers have revealed how a factory inside cells builds ribosomes, the machinery responsible for protein synthesis. The system opens the door to treatments and medicines.

I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.

https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology

Welcome and follow @antebilab.bsky.social if you are interested in #ageing science, related cell signalling pathways involving #mTOR, the #nucleolus, #ribosomes and so much more! 🧫🪱🧬🔬 And of course shout out to @mpiage.bsky.social, too 👩‍🔬

#DigitalHolographicMicroscopy
+#DeepLearning automated quantitation

Detects the optical thickness of #Nucleolus, (Huntingtin, TDP-43, ataxin-3) Aggregate, #StressGranule, #LipidDroplet in cultured cells

#Emboreports 2024
www.embopress.org/doi/full/10....