⏪ G&D RECAP ⏪

🗓️ July 2025
RESEARCH PAPER: Ribosome association inhibits stress-induced gene mRNA localization to stress granules
By Noah Helton, Benjamin Dodd, and Stephanie Moon
➡️ https://genesdev.cshlp.org/content/39/13-14/826.full

Stephanie Moon
#ribosome #stressgranule #translation

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial co...

#Article in #MedComm

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis doi.org/10.1002/mco2...

#ATP #mitochondria #MycobacteriumTuberculosis #Mtb #StressGranule #tuberculosis

Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets - Molecular Biomedicine Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in mult...

#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...

#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule

Ru et al. show that the accumulation of RNA lariats in human DBR1-deficient cells impairs #StressGranule assembly–mediated PKR activation, and thereby cell-intrinsic antiviral immunity. rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

In @jcb.org, the Tu lab show that a polymorphism in the Mkt1 gene underlies complex genetic phenotypes among strains of budding yeast. Mkt1 interacts w/ a #StressGranule protein Pbp1 to regulate expression of mitochondrial proteins, TORC1 signaling, & #autophagy in yeast. rupress.org/jcb/article/...

Caballero, Tu et al. show that a polymorphism in the Mkt1 gene underlies complex genetic phenotypes among strains of budding yeast. Mkt1 interacts with a #StressGranule protein Pbp1 to regulate expression of mitochondrial proteins, TORC1 signaling, & #autophagy in yeast. rupress.org/jcb/article/...

#DigitalHolographicMicroscopy
+#DeepLearning automated quantitation

Detects the optical thickness of #Nucleolus, (Huntingtin, TDP-43, ataxin-3) Aggregate, #StressGranule, #LipidDroplet in cultured cells

#Emboreports 2024
www.embopress.org/doi/full/10....