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“If you have #tuberculosis (#TB), bacteria (usually #MycobacteriumTuberculosis) ..It is curable with antibiotics,

but if left untreated, active TB can cause severe lung damage, spread to other organs (like the brain or spine), and be fatal.
Cleveland Clinic”

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Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and Mycobacterium tuberculosis in macrophages and humanized mice Untreated coinfections with HIV-1 and Mycobacterium tuberculosis are lethal since the causative pathogens survive within CD4 T cells and macrophages evading immune control. Jagannath and colleagues de...

Research out of @houstonmethodist.bsky.social proposes that Sirt2 blockade and Sirt1-activation represent a novel dual therapeutic strategy for treating #HIV-1 and #MycobacteriumTuberculosis co-infections. | @moltherapy.bsky.social 🎯

🤩 Check it out: https://bit.ly/4d4BERX

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial co...

#Article in #MedComm

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis doi.org/10.1002/mco2...

#ATP #mitochondria #MycobacteriumTuberculosis #Mtb #StressGranule #tuberculosis

Defining the Mycobacterium tuberculosis Pangenome and Suggestions for a New Composite Reference Sequence. #MycobacteriumTuberculosis #Pangenome #ReferenceSequence @biorxivpreprint.bsky.social 🧪
www.biorxiv.org/content/10.1...

This study demonstrates the effectiveness of targeted #NextGenerationSequencing of #BronchoalveolarLavage fluid in detecting both #MycobacteriumTuberculosis and #NontuberculousMycobacteria infections, highlighting its promise as a diagnostic tool for future #Clinical use. #medsky

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Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics reveals gene expression as a...

#Medsky🧪 #IDsky #immunosky #episky #publichealth @cellpress.bsky.social
#Mycobacteriumtuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, & disease phenotypes.
www.cell.com/cell/fulltex...

Tuberculosis (TB): Causes, Symptoms, Diagnosis, and Treatment Explained
#Tuberculosis #StopTB #TBawareness #InfectiousDiseases #PublicHealth #GlobalHealth #LungHealth #VikaasShandily #MycobacteriumTuberculosis

#simpsons #marge #Löwenstein #agar #Lowenstein-Jensen #Mycobacterium #Mycobacteriumtuberculosis #tb #lab #medsky #medtech #mls #microbiology

UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis of Mycobacterium tuberculosis
Bell, J. M., Comas, I. et al.
Paper
Details
#MycobacteriumTuberculosis #PhylogenomicAnalysis #UsherTBStudy

Read the latest Journal of #Infection for the examination of how latent #TBInfection, evaluated by cell-mediated immune responses to #MycobacteriumTuberculosis antigens, impacts glucose metabolism in US adults 👉 www.journalofinfecti...

Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2
Bi, l., Chen, Y. et al.
Paper
Details
#ASpks2 #MycobacteriumTuberculosis #MacrophageSurvival

Structural analysis of M. tuberculosis Rv2173 reveals a canonical class I diterpene synthase fold and supports its annotation as a short-chain product-length synthase #MycobacteriumTuberculosis #IsoprenylDiphosphateSynthase #Rv2173 doi.org/10.1107/S205...

S-Adenosyl-N-decyl-aminoethyl is identified as a promising potential inhibitor for the SAM-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis #SAMDependentMycolicAcidSynthase #UmaA #MycobacteriumTuberculosis doi.org/10.1107/S205...

It is estimated that 20% of M.tb isolates globally are resistant to at least one agent, and these strains are associated with a similar proportion of worldwide TB death
www.frontiersin.org/journals/mic...
@who.int issued 1st edi catalogue of #Mycobacteriumtuberculosis complex (MTBC) mutations

The N-terminal domain of hypothetical protein Rv1421 from Mycobacterium tuberculosis H37Rv was crystallized and its ligand-binding abilities were analyzed @ActaCrystF @IUCr #MycobacteriumTuberculosis #Rv1421 #WalkerABLikeMotif
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