Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets - Molecular Biomedicine Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in mult...

#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...

#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring Harbor Laboratory).

Mysterious #NuclearSpeckles could unlock new answers in #KidneyCancer. In PNAS Journal Club: www.pnas.org/post/journal...

#GeneRegulation #p53 #NuclearSpeckle #cancer #CancerTherapy

Nuclear speckles regulate functional programs in cancer Nature Cell Biology - This study reports that nuclear speckle constituents have two expression states in cancer correlating with patient survival and HIF-2α functional programs. HIF-2α...

💫NEW by Berger & co: #NuclearSpeckle (NS) constituents have 2 expression states in #cancer correlating with patient survival & HIF-2α functional programs. HIF-2α mediates NS association of key genes activated in renal cancer.
rdcu.be/d56c7
www.nature.com/articles/s41...