Our TDP-43-paraspeckle paper is now published in Nature Cell Biology! 🎉

www.nature.com/articles/s41...

A Nature Research Briefing on this study will follow shortly.

Congratulations to joint first authors Rachel, Cara and Ruaridh👍

#paraspeckle #condensates #TDP-43 #ALS

Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets - Molecular Biomedicine Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in mult...

#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...

#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule

Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention - Nature Metabolism Zhao, Chai and colleagues. show that proline regulates hepatic gluconeogenesis by modulating mRNA retention in paraspeckle structures, thus contributing to glycaemic control in type 2 diabetes.

RESEARCH | Y Zhao, X Chai, C Luo, J Sheng et al. (Zhejiang Uni, CN)

#Proline regulates hepatic #gluconeogenesis by modulating mRNA retention in #paraspeckle structures, thus contributing to #glycemic control in type 2 #diabetes.

https://bit.ly/41QnqwV