Is #fat bad for #immunotherapy ? The clear answer: yes...and no! Adipose tissue plays an important role in #cancer. This new work is giving insights how #innateimmunity works ... @natureportfolio.nature.com #science @sigtrans-sttt.bsky.social @dkfz.bsky.social
doi.org/10.1038/s413...
ICYMI: This collection highlights the latest discoveries in the field of #InnateImmunity in viral #infection, barrier defense, liver health, #inflammation, and #cancer. Explore latest discoveries in JEM 👉 rupress.org/jem/collecti...
The resolution of #inflammation is essential for homeostasis and becomes defective with age. In @jem.org, Bex, Pellefigues et al. @upcite.bsky.social show that #basophils infiltrate wounds to promote the resolution and healing in both adult and aged mice. rupress.org/jem/article/...
#InnateImmunity
The resolution of #inflammation is essential for homeostasis and becomes defective with age. Here, Bex, Pellefigues et al. @upcite.bsky.social show that #basophils infiltrate wounds to promote the resolution and healing in both adult and aged mice. rupress.org/jem/article/...
#InnateImmunity
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity. From Yan Xu and colleagues: rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Role for NF-κB in #herpes #encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity. From from Manja Idorn, Søren R. Paludan and colleagues: rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Lung tissue-resident memory T cells optimize protection by IL-10 regulation of #InnateImmunity. From Alexander Yang, Donna Farber and colleagues: rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal #necroptosis in TNF-treated mice, say Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang and colleagues rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Monogenic disorders of the IRF transcription factors. Review by Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey @turveylab.bsky.social: rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
RIPK1 autophosphorylation at S161 mediates cell death and #inflammation. From Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis: rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Happening soon - meet our immunology editor Ioannis Papaioannou at @keystonesymposia.bsky.social
#InnateImmunity in beautiful Banff!
#KSInnateImmune26
hubs.la/Q03TCrHw0
📢 New research by #CiViA members M Møhlenberg, T Mogensen et al. published in @pnas.org: "Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2"
www.pnas.org/doi/10.1073/...
#Biomedicine #COVID19 #Immunology #InnateImmunity
#Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis. New study from Wei-Yao Chin, Shi-Chuen Miaw et al. (National Taiwan University): rupress.org/jem/article/...
#InnateImmunity #inflammation #InfectiousDisease #HostDefense #Mitochondria
Does fever drive the #evolution of antiviral genes? Perspective by Ryan Langlois @langloislab.bsky.social rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous #dsRNA. new study from Chaorui Duan, William G. Fairbrother @brown.edu and colleagues: rupress.org/jem/article/...
@casanovalab.bsky.social
#InnateImmunity #inflammation
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1, from Ran Liu, Gengqiao Wang, Zhengting Jiang, Jinyang Gu et al. rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
#Myeloid diversity in tumors: shaped by genes, location, and time. New review from Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, & María Casanova-Acebes @casanova-acebes.bsky.social @cniostopcancer.bsky.social: rupress.org/jem/article/...
#CancerFocus #InnateImmunity
Li et al. find that in #Paneth cells, ERAdP senses c-di-AMP derived from intestinal microbiota, activating dense core vesicle biogenesis and AMP secretion to enhance intestinal defense. rupress.org/jem/article/...
📘 In our #InnateImmunity collection: rupress.org/jem/collecti...
#KSInnateImmune26
Our new collection highlights the latest discoveries in the field of #InnateImmunity in viral infection, barrier defense, liver health, inflammation, and cancer. Explore latest discoveries to accompany @keystonesymposia.bsky.social meeting on the topic:
rupress.org/jem/collecti...
#KSInnateImmune26
@jem.org's new collection highlights the latest discoveries in the field of #InnateImmunity in viral infection, barrier defense, liver health, inflammation, and cancer. Latest discoveries to accompany @keystonesymposia.bsky.social meeting on the topic:
rupress.org/jem/collecti...
#KSInnateImmune26
The STING HAQ haplotype and clinical non-penetrance in COPA syndrome. New report from Clémence David, Marie-Louise Frémond @mlfremond.bsky.social @institutimagine.bsky.social @upcite.bsky.social and colleagues: rupress.org/jem/article/...
#HumanDiseaseGenetics #InnateImmunity #inflammation
New work @jem.org from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...
#InnateImmunity #Inflammation
New work from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...
#InnateImmunity #Inflammation
⏰ Reminder: There’s still time to register & submit an abstract for the 21st International Conference on Innate Immunity!
🎓 Travel awards available
📅 May 22–27, 2026 | 📍 Kalimera Kriti Hotel & Conference Center 🇬🇷
#InnateImmunity #Immunology aegeanconferences.org/src/App/conf...
Schematic overview of the findings of the publication by Suarez-Csrmona et al.
New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to […]
[Original post on mstdn.science]
🧫 Join us in Crete 🇬🇷 for the 21st Intl Conf. on Innate Immunity (May 22–27, 2026)!
🎓 Students & trainees—travel awards available!
📍 Kalimera Kriti Conf. Center
🔗 www.aegeanconferences.org/src/App/orga...
#InnateImmunity #Immunology #ScienceTravel
In @jem.org, David, @mlfremond.bsky.social et al. investigate whether the common HAQ STING allele explains clinical non-penetrance in COPA syndrome. rupress.org/jem/article/...
#HumanDiseaseGenetics #InnateImmunity #inflammation
David, @mlfremond.bsky.social et al. investigate whether the common HAQ STING allele explains clinical non-penetrance in COPA syndrome. rupress.org/jem/article/...
#HumanDiseaseGenetics #InnateImmunity #inflammation
New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...
#Metabolism #MucosalImmunology #InnateImmunity #inflammation
