Recent pair of earrings in my ongoing #mseries #sciart #jewellery , sterling silver, kyanite, Pearl and needled felt, inspired by the morphology of #monocytes they’re very dangly!

#Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow #monocytes after #stroke. New study from Weijie Chen, Xin Wang, Tingting Huang, Weifeng Yu, Florent Ginhoux, Peiying Li (Shanghai Jiao Tong University) and colleagues:
rupress.org/jem/article/...

#Neuroinflammation

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy Background Resistance to immune checkpoint inhibitors represents a major therapeutic challenge, as less than 50% of patients with melanoma achieve long-term response to immune checkpoint inhibitor therapy. One mechanism of acquired resistance involves somatic mutations, such as loss of beta-2 microglobulin ( B2m ), that enable tumor cells to evade T cell-mediated killing. Methods This study used single-cell RNA-seq, flow cytometry, and ex vivo functional assays to characterize tumor-infiltrating immune cells in antigen presentation-deficient tumors. Tumor-bearing mice were treated with anti-PD-1 or CD40 agonist antibodies and cell depletion or cytokine blocking antibodies to define mechanisms of action. Analysis of published human RNA-seq datasets was performed to dissect the contributions of inflammatory monocytes to patient outcomes. Results We found an increase in immunosuppressive macrophages in B2m -null tumors. We hypothesized that repolarizing myeloid cells may restore control of tumor growth. Treatment with CD40 agonist antibody, which promotes differentiation of monocytes and macrophages towards a proinflammatory phenotype, reduced tumor growth and improved survival in B2m -null melanoma and colorectal cancer models. Unexpectedly, both CD8+ T cells and NK cells, but not CD4+ T cells, were required for the efficacy of CD40 agonist, even though CD8+ T cells cannot directly recognize antigen presentation-deficient tumor cells. Instead, these lymphocytes control tumor growth via secretion of IFNγ, as depletion of IFNγ inhibited the therapeutic effect of CD40 agonist. IFNγ receptor ( Ifngr1 ) expression was required on host cells, not tumor cells, for CD40 agonist-mediated tumor control. Single-cell analysis identified a distinct population of inflammatory monocytes that were enriched for an IFNγ response signature in CD40 agonist-treated tumors, suggesting that these cells may be important for tumor control. Analysis of human bulk and single-cell RNA-seq datasets demonstrated that an inflammatory monocyte signature derived from our data was associated with improved patient outcomes and response to immune checkpoint inhibitors. Conclusions These data demonstrate that CD8+ T cells contribute to tumor control even in the absence of direct antigen presentation by tumor cells. More broadly, our work suggests that strategies to activate the effector functions of inflammatory monocytes may limit tumor growth and overcome acquired resistance to immune checkpoint inhibitors. ### Competing Interest Statement PKS is a co-founder and member of the BOD of Glencoe Software, member of the SAB for RareCyte, Reverb Therapeutics and Montai Health, and consultant for Merck. He holds equity in Glencoe and RareCyte. WNH is an employee and holds equity in Arsenal Biosciences. AHS has patents or pending royalties on the PD-1 pathway from Roche and Novartis. AHS is on advisor boards for Elpiscience, Alixia, Monopteros, GlaxoSmith Kline, Janssen, Amgen, Corner Therapeutics, Bioentre, AltruBio, ImmVue and MabQuest. AHS also is on scientific advisory boards for the Massachusetts General Cancer Center, Program in Cellular and Molecular Medicine at Boston Childrens Hospital, the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, Perlmutter Cancer Center at NYU, the Gladstone Institutes and the Johns Hopkins Bloomberg-Kimmel Institute for Cancer Immunotherapy. She receives research funding from TaiwanBio, unrelated to this paper. She is an academic editor for the Journal of Experimental Medicine. BCM has consulted for Cellarity, LifeOmic, and Telix Pharmaceuticals. * B2m : beta-2 microglobulin MHC-I : major histocompatibility complex I TNF : tumor necrosis factor TAM : tumor-associated macrophage IFN : interferon LPS : lipopolysaccharide agCD40 : CD40 agonist scRNAseq : single-cell RNA-sequencing TME : tumor microenvironment TIL : tumor-infiltrating lymphocyte National Institute of General Medical Sciences, https://ror.org/04q48ey07, T32 GM133364, T32 GM007753 National Cancer Institute, K08CA248960 Burroughs Wellcome Fund, https://ror.org/01d35cw23, CAMS Gene Lay Institute Ludwig Center at Harvard The Mark Foundation for Cancer Research, https://ror.org/00v7th354, ASPIRE award American Cancer Society, https://ror.org/02e463172, Research Scholar Grant PF-24-1316850-01-CD

Tomorrow, in #preprinthub2 Teresa @cemm.oeaw.ac.at will present a preprint from Brian Miller’s lab on how inflammatory #monocytes can be harnessed to overcome resistance to #anti-PD-1 #immunotherapy 🐁🚧🛑

www.biorxiv.org/content/10.6...

#immunosky

Sensing of metabolic signals via GPR183 promotes occupation of lung #macrophage niches by #monocytes. New study from Laura Bub, Elza Evren, Stijn Verwaerde, Thomas Marichal, Bart Lambrecht, Tim Willinger @ki.se et al.: rupress.org/jem/article/...

#Metabolism #MucosalImmunology #inflammation

New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity #inflammation

New study @jem.org from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity

Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
... Continue to: youtube.com/shorts/eae1l...

Recruitment of CCR5+ inflammatory monocytes in pulmonary tissue contributes to acute lung injury - Genes & Immunity Genes & Immunity - Recruitment of CCR5+ inflammatory monocytes in pulmonary tissue contributes to acute lung injury

🌅 #Research #Alert
Recruitment of CCR5+ #inflammatory #monocytes in #pulmonary #tissue contributes to #acute #lung #injury

@springernature.com #Genes & #Immunity
www.nature.com/articles/s41...

Graphical abstract of the original paper, source: original paper

🧬 New research finds activating the cGAS–#STING pathway in human #monocytes triggers a unique form of regulated cell death — a blend of #apoptosis and #pyroptosis dubbed “pyroptotic apoptosis.” This links mitochondrial stress to immune signaling and inflammation.

🔗 buff.ly/6EoEosJ

(MK)

A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443...

By JL Lan, CA Yang and colleagues at China Medical University Taichung

🙏 Huge thanks to all my co-authors and collaborators - this was a truly team effort!
Grateful for the support of the Dyer, Illidge and Travis lab and everyone in RadNet who helped make this project possible. @cruk-mi.bsky.social

#Immunology #Radiobiology #Monocytes #TissueRepair #Research #Science

Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
... Continue to: youtube.com/shorts/eae1l...

Monocytes: normal values and causes of their increase/decrease in blood #monocytes #whitebloodcells
... Continue to: youtube.com/shorts/eae1l...

Really interesting story from @gastrogrj.bsky.social - murine and human data showing that #activin signaling in intestinal #monocytes is key for epithelial barrier repair during intestinal #inflammation #EMDS2025

#EMDS2025 begins! Looking forward to a few days of exciting science about all things #macrophage, #dendriticcells and #monocytes in beautiful Edinburgh

Episode 58 - Not even my final form | Approach to Monocytosis — Bloody Minded Put on your monocles and kimonos and hop on the monorail to our episode composed of monotonous monologues, monogamously dedicated to that most monolithic and sometimes monoclonal of mononucleated cell...

You heard it right- we are now a musical podcast! We also talk for a while about #monocytes. If anyone knows why exactly HCL causes a monocytopenia we are all ears #meded #hemesky #ancientsimpsonsreferences

www.bloodyminded.com.au/allepisodes/...

Neutrophils & monocytes are sentinels of inflammatory signals, migrating along endothelial boundaries to reach sites of action. Honig & co show that #neutrophils & #monocytes migrate along endothelial cell boundaries in vitro to optimise search efficiency. 🔬
doi.org/10.1242/bio....

Targeting monocyte dynamics in MS?

In Immunotherapy Advances, Bibi et al. explore how shifting monocytes from inflammatory to reparative states may reshape MS treatment strategies.

📘 https://bit.ly/3EXOfaV

#MS #Monocytes #Neuroinflammation

Short-term high fructose intake can boost bacterial toxin receptors, raising inflammation risk Despite medical advances, infectious diseases caused by bacteria and viruses are still among the most common causes of death worldwide. What role could fructose play in such diseases?

Short-term high #fructose intake can boost #bacterial #toxin receptors ...

| #bacteria | #microbes | #inflammation | #monocytes | By @univie.ac.at‬ via @sciencex.bsky.social‬

A research group at the @univie.ac.at Universität Wien / University of Vienna has shown for the first time that #monocytes, important #immune cells in the #blood, react more strongly to #bacterial #toxins after #fructose consumption - but not in a good way. www.sciencedirect.com/science/arti...

This study explores how neutrophil and monocyte to HDL-cholesterol ratios increase with the triglyceride-glucose index, highlighting inflammation as a key link to cardio-metabolic syndromes.
#IJCTM #TyG #neutrophils #monocytes #inflammation
www.sciltp.com/journals/ijc...

Frontiers | Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia IntroductionThe pathogenesis of biliary atresia (BA) is unclear to date and no therapies targeting immune regulatory pathways exist. Here we characterized po...

Fresh research out today, from our talented PhD student - congrats Freya!! #monocytes #Tcells and #liver ...what's not to love?

www.frontiersin.org/articles/10....

What’s in the blood? Immune cell changes in schizophrenia buff.ly/WWGE3Qz

#Schizophrenia #Psychosis #Inflammation #Neutrophils #Monocytes

🧵 THREAD

Beyond AIM2, systems biology revealed suggestive loci linked to innate immunity mediated by #monocytes and #NK cells (KLRs and NCR3), upstream cytokines IL-6 and IFN-γ, neuronal pathways (AUTS2, NGF, NPAS3), and lipid metabolism (LDLR, CD36, HMGCR, LPIN2), experimentally validated in #metabolomics

The persistence of vaccine-derived S1 protein in CD16+ #monocytes and an altered cytokine profile were detected up to 245 days after #vaccination in SARS-CoV-2-uninfected individuals with post-COVID-19 vaccination syndrome

#spike #SARSCoV2

discovermednews.com/the-persiste...

Super proud of 3rd year PhD student Katie Lambert, who won a people's choice award for her excellent talk on Effector T cell-modulated #monocytes resemble myeloid cells from the site of inflammation at the recent #PhD symposium of our School of #Immunology and #Microbial Sciences. Well done Katie 🎉🤩

Infant Immune Systems Respond Differently to Severe COVID-19 | Newswise A St. Jude-led collaboration characterized the unique features of hospitalized infants’ immune response to SARS-CoV-2, the virus that causes COVID-19.

Infant Immune Systems Respond Differently to Severe COVID-19
www.newswise.com/articles/inf...
#COVID19 #infectiousdiseases #monocytes #SARSCoV2

🎉Congratulations to Dr. Carole Perrot, et al. on receiving the #AJPCell Best Review Article Award for 2024! 🏆
Honored at #APS2025.
ow.ly/i1hZ50VLBuF
#Macrophages #Monocytes

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 μm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 μm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org 🧪 plos.io/3RryCLF

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 μm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 μm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org 🧪 plos.io/3RryCLF